Joint association between physical exercise, caffeine intake, and biological ageing: A cross-sectional analysis of population-based study DOI Creative Commons
Guang Chen,

Siwei Zhou,

Yunqing Xun

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0323264 - e0323264

Published: May 7, 2025

Background Ageing is a significant risk factor for age-related diseases, accounting 51% of global total disease burden. As thus, promoting healthy ageing crucial. Although several potential anti-ageing drugs show promise, none have been approved purpose. The World Health Organization (WHO) recommends physical exercise exceeding 600 metabolic equivalent task (MET) minutes per week adults. However, whether positively impacts biological remains unclear. Objective This study aimed to investigate the joint correlation between MET level, caffeine consumption, and ageing. Methods We analyzed data from seven survey cycles (2007–2020) National Nutrition Examination Survey (NHANES), involving 23,739 participants. Physical activity levels were measured in week, was assessed using both PhenoAge ENABL Age algorithms. Generalized linear regression employed test correlations, adjusting confounding factors. A cubic spline model used detect non-linear relationships. Pre-specified subgroup analyses explored effect modifications, while predefined sensitivity confirmed robustness results. Results Each 100-MET increase weekly associated with 0.2-year delay (p < 0.001 Age). Individuals less than had higher accelerated compared those (mean difference [MD]: 2.2 years, 95% CI [1.5–2.8], p 0.001; MD: 2.1 [1.1–3.1], 0.001). L-shaped association observed, diminishing benefits delayed beyond 292 259 Age. Daily intake did not modify interaction > 0.05). Stronger effects observed non-Hispanic Black individuals, obesity, low-income populations, but no benefit found cancer patients. Conclusions Our findings highlight positive plateau specific thresholds. Caffeine does influence this relationship. These results underscore importance at appropriate as strategy management general population.

Language: Английский

A high-resolution view of the heterogeneous aging endothelium DOI Creative Commons
Sarah Dobner,

Fanni Tóth,

Laura de Rooij

et al.

Angiogenesis, Journal Year: 2024, Volume and Issue: 27(2), P. 129 - 145

Published: Feb. 7, 2024

Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While studies confined to the investigation of aging-associated vascular readouts in one or few tissues have already drastically expanded our understanding EC aging, single-cell omics other high-resolution profiling technologies started illuminate intricate molecular changes underlying across diverse beds at scale. In this review, we provide an overview recent insights into heterogeneous adaptations endothelium. We address critical questions regarding tissue-specific universal responses endothelium process, turnover dynamics throughout lifespan, differential susceptibility ECs acquiring traits. doing so, underscore transformative potential approaches advancing comprehension essential foster development future innovative therapeutic strategies for conditions.

Language: Английский

Citations

6
Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan DOI Creative Commons
Francesca Matteini, Sara Montserrat‐Vazquez, Maria Carolina Florian

et al.

FEBS Letters, Journal Year: 2024, Volume and Issue: 598(22), P. 2776 - 2787

Published: April 11, 2024

Aging is associated with a global decline in stem cell function. To date, several strategies have been proposed to rejuvenate aged cells: most of these result functional improvement the tissue where cells reside, but impact on lifespan whole organism has less clearly established. Here, we review some recent work dealing interventions that improve regenerative capacity somatic mammals and might important translational possibilities. Overall, underscore rejuvenation represents strategy homeostasis upon aging present approaches potential affect health span organism.

Language: Английский

Citations

6
The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials DOI Open Access
Andrea Rivera,

John R. Normanton,

Arthur M. Butt

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4452 - 4452

Published: April 18, 2024

Schizophrenia is a significant worldwide health concern, affecting over 20 million individuals and contributing to potential reduction in life expectancy by up 14.5 years. Despite its profound impact, the precise pathological mechanisms underlying schizophrenia continue remain enigmatic, with previous research yielding diverse occasionally conflicting findings. Nonetheless, one consistently observed phenomenon brain imaging studies of patients disruption white matter, bundles myelinated axons that provide connectivity rapid signalling between regions. Myelin produced specialised glial cells known as oligodendrocytes, which have been shown be disrupted post-mortem analyses patients. Oligodendrocytes are generated throughout major population oligodendrocyte progenitor (OPC), essential for matter plasticity. Notably, decline specific subpopulation OPC has identified principal factor loss aging brain, suggesting this may also schizophrenia. In review, we analysed genomic databases pinpoint intersections identify shared cognitive dysfunction.

Language: Английский

Citations

5
Exploring the heterogeneous targets of metabolic aging at single-cell resolution DOI
Shuhui Sun, Mengmeng Jiang, Shuai Ma

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

5
Spatial transcriptomic clocks reveal cell proximity effects in brain ageing DOI Creative Commons
Eric Sun, Olivia Y. Zhou, Max Hauptschein

et al.

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Old age is associated with a decline in cognitive function and an increase neurodegenerative disease risk1. Brain ageing complex accompanied by many cellular changes2. Furthermore, the influence that aged cells have on neighbouring how this contributes to tissue unknown. More generally, tools systematically address question tissues not yet been developed. Here we generate spatially resolved single-cell transcriptomics brain atlas of 4.2 million from 20 distinct ages across adult lifespan two rejuvenating interventions—exercise partial reprogramming. We build spatial clocks, machine learning models trained atlas, identify cell-type-specific transcriptomic fingerprints ageing, rejuvenation disease, including for rare cell types. Using clocks deep learning, find T cells, which increasingly infiltrate age, marked pro-ageing proximity effect cells. Surprisingly, neural stem strong pro-rejuvenating also potential mediators their neighbours. These results suggest types can potent neighbours could be targeted counter ageing. Spatial represent useful tool studying cell–cell interactions contexts should allow scalable assessment efficacy interventions disease. A map mouse at different reveals signatures effects

Language: Английский

Citations

5
Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging DOI Creative Commons
Robin W. Yeo, Olivia Y. Zhou, Brian L. Zhong

et al.

Nature Aging, Journal Year: 2023, Volume and Issue: 3(7), P. 866 - 893

Published: July 13, 2023

The regenerative potential of brain stem cell niches deteriorates during aging. Yet the mechanisms underlying this decline are largely unknown. Here we characterize genome-wide chromatin accessibility neurogenic niche cells in vivo Interestingly, at adhesion and migration genes decreases with age quiescent neural (NSCs) but increases activated (proliferative) NSCs. Quiescent NSCs exhibit opposing behaviors aging: become less adhesive, whereas more adhesive. Old also show decreased vitro diminished mobilization out for neurogenesis vivo. Using tension sensors, find that aging force-producing adhesions Inhibiting cytoskeletal-regulating kinase ROCK reduces these adhesions, restores old vitro, boosts These results have implications restoring migratory improving aged brain.

Language: Английский

Citations

13
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging DOI Creative Commons
Siyi Zhou,

Zeming Li,

Xinzhu Li

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Tissues maintain their function through interaction with microenvironment. During aging, both hair follicles and blood vessels (BV) in skin undergo degenerative changes. However, it is elusive whether the changes are due to intrinsic aging or respectively, interactions. To explore how interact regulate angiogenesis regeneration during aging. Single-cell RNA-sequencing (scRNA-seq) analyses were used identify declined ability of dermal papilla (DP) endothelial cells (ECs) CellChat CellCall performed investigate between DP ECs. metabolism (scMetabolism) analysis iPATH applied analyze downstream metabolites Hair-plucking model mouse cell organoid for functional studies. distance ECs decreased. interacts ECs, decreased EDN1-EDNRA signaling from CTF1-IL6ST ECs-secreted EDN1 binds DP-expressed EDNRA which enhances Taurine (TA) promote regeneration. DP-emitted CTF1 ECs-expressed IL6ST activates alpha-linolenic acid (ALA) angiogenesis. Activated EDN1-EDNRA-TA promotes aged cultures, increased CTF1-IL6ST-ALA also cultures. Our finding reveals reciprocal interactions DP. releases sensed by activate TA induces regeneration, while emits signal received enhance ALA study provides new insights into mutualistic cellular crosstalk vessels, identifies novel contributing normal skin.

Language: Английский

Citations

4
Brain aging and rejuvenation at single-cell resolution DOI Creative Commons
Eric Sun, Rahul Nagvekar, Angela N. Pogson

et al.

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 82 - 108

Published: Jan. 1, 2025

SummaryBrain aging leads to a decline in cognitive function and concomitant increase the susceptibility neurodegenerative diseases such as Alzheimer's Parkinson's diseases. A key question is how changes within individual cells of brain give rise age-related dysfunction. Developments single-cell "omics" technologies, transcriptomics, have facilitated high-dimensional profiling cells. These technologies led new comprehensive characterizations at resolution. Here, we review insights gleaned from omics studies aging, starting with cell-type-centric overview age-associated followed by discussion cell-cell interactions during aging. We highlight provide an unbiased view different rejuvenation interventions comment on promise combinatorial approaches for brain. Finally, propose directions, including models neural stem focal point rejuvenation.

Language: Английский

Citations

0
Tissue-resident skeletal muscle macrophages promote recovery from viral pneumonia-induced sarcopenia in normal aging. DOI Creative Commons
Constance E. Runyan, Lucy Luo, Lynn C. Welch

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Sarcopenia, which diminishes lifespan and healthspan in the elderly, is commonly exacerbated by viral pneumonia, including influenza COVID-19. In a study of A pneumonia mice, young mice fully recovered from sarcopenia, while older did not. We identified population tissue-resident skeletal muscle macrophages that form spatial niche with satellite cells myofibers but are lost age. Mice gain-of-function mutation Mertk receptor maintained this macrophage-myofiber interaction during aging influenza-induced sarcopenia. contrast, deletion or loss Cx3cr1 disrupted niche, preventing regeneration. Heterochronic parabiosis not restore old mice. These findings suggest age-related disrupts cellular signaling necessary for regeneration after offering potential target to mitigate sarcopenia aging.

Language: Английский

Citations

0
Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention DOI Creative Commons
Xuan Lu, Ying Chen, Yue Shi

et al.

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 200, P. 112685 - 112685

Published: Jan. 16, 2025

Language: Английский

Citations

0