bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 22, 2024
Regeneration and homeostatic turnover of solid tissues depend on the proliferation symmetrically dividing adult stem cells, which either remain cells or differentiate based their niche position. Here we demonstrate that in zebrafish lateral line sensory organs, progenitor cell are independently regulated by two
Language: Английский
Cell stem cell, Journal Year: 2024, Volume and Issue: 31(5), P. 617 - 639
Published: May 1, 2024
Language: Английский
Citations
63
Cell, Journal Year: 2024, Volume and Issue: 187(14), P. 3461 - 3495
Published: June 20, 2024
Developmental biology-the study of the processes by which cells, tissues, and organisms develop change over time-has entered a new golden age. After molecular genetics revolution in 80s 90s diversification field early 21st century, we have phase when powerful technologies provide approaches open unexplored avenues. Progress has been accelerated advances genomics, imaging, engineering, computational biology emerging model systems ranging from tardigrades to organoids. We summarize how revolutionary led remarkable progress understanding animal development. describe classic questions gene regulation, pattern formation, morphogenesis, organogenesis, stem cell are being revisited. discuss connections development with evolution, self-organization, metabolism, time, ecology. speculate developmental might evolve an era synthetic biology, artificial intelligence, human engineering.
Language: Английский
Citations
11
Nature, Journal Year: 2024, Volume and Issue: 633(8028), P. 198 - 206
Published: Sept. 4, 2024
Language: Английский
Citations
9
Developmental Biology, Journal Year: 2024, Volume and Issue: 516, P. 71 - 81
Published: July 24, 2024
The dentition is critical to animal survival and teeth are present in modern vertebrates including teleost fish, sharks, amphibians, mammals reptiles. developmental processes that give rise not just preserved through evolution but also share high level of similarity with the embryogenesis other ectodermal organs. In this review we go beyond embryonic phase tooth development life-long replacement. We will address origins successional teeth, location putative tissue-resident stem cells, how de novo formation continues throughout life shed a spatially temporally controlled manner. evidence dental epithelium, which earliest recognizable structure reptilian dentition, serves as niche for epithelial cells recent molecular findings from transcriptomics carried out dentitions. discuss odontoclasts resorb primary allowing eruption tooth. reptiles, particularly lizards, emerging some most accessible animals study replacement has relevance human disorders.
Language: Английский
Citations
5
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 15, 2024
Summary The release and subsequent detection of nucleic acids into the cytoplasm constitute a hallmark radiation-induced DNA damage response. However, different radiation types, such as photons protons, may elicit distinct responses, uniquely influencing normal stem cell activity tissue regeneration. Here, we show that proton irradiation leads to enhanced derepression transposable elements (TEs) with consequent activation salivary gland stem/progenitor cells. This response is mediated by pronounced loss heterochromatin regulators accumulation cytoplasmic TE-derived dsRNA, resulting in upregulation RIG-I augmented interferon-beta (IFN-β) signaling. Single RNA sequencing (scRNA-seq) TE dynamics analyses corroborate these findings, specifically subpopulation Sox9 -expressing cells increased INF-β These data reveal presence IFN-β microenvironment irradiated organoids increases organoid growth, pointing advantages therapy over photon-based radiotherapy.
Language: Английский
Citations
4
Aging, Journal Year: 2024, Volume and Issue: unknown
Published: May 9, 2024
Adipose tissue regulates metabolic balance, but aging disrupts it, shifting fat from insulin-sensitive subcutaneous to insulin-resistant visceral depots, impacting overall health. Adipose-derived stem cells (ASCs) are crucial for regeneration, diminishes their stemness and regeneration potential. Our findings reveal that is associated with a decrease in adipose mass an increase the depots mass. Aging fibrosis no significant change adipocyte size was observed age. Long term caloric restriction failed prevent fibrotic changes resulted adipocytes size. Aged ASCs displayed increased production of ROS. Using mitochondrial membrane activity as indicator cell quiescence senescence, we age exclusively depot. In addition, aged accumulated more senescent having defective autophagy activity. However, long-term leads reduction ASCs. Furthermore, prevents accumulation helps retain These results suggest mimetics hold promise potential strategy rejuvenate Further investigations, including
Language: Английский
Citations
4
Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 392 - 405
Published: Sept. 29, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 671 - 671
Published: Jan. 14, 2025
Human hematopoietic stem cells (HSCs) have traditionally been viewed as self-renewing, multipotent with enormous potential in sustaining essential steady state blood and immune cell production throughout life. Indeed, around 86% (1011-1012) of new generated daily a healthy young human adult are origin. Therapeutically, HSCs contributed to over 1.5 million transplants (HCTs) globally, making this the most successful regenerative therapy date. We will commence review by briefly highlighting selected key achievements (from 1868 end 20th century) that accomplishment. Much our knowledge hematopoiesis is based on small animal models that, despite their importance, do not always recapitulate hematopoiesis. Given this, we critically progress challenges faced identifying tracing lineage differentiation trajectories, referring murine studies needed. Moving forward given dynamic can readily adjust variety stressors, then discuss recent research advances contributing understanding (i) which HSPCs maintain hematopoiesis, (ii) where these located, (iii) mechanisms come into play when homeostatic switches stress-induced or emergency
Language: Английский
Citations
0
Cell Regeneration, Journal Year: 2025, Volume and Issue: 14(1)
Published: Jan. 24, 2025
Abstract Salivary gland stem/progenitor cells (SSPCs) hold significant potential for regenerative medicine, especially patients suffering from salivary dysfunction due to various causes such as radiation therapy, Sjögren’s syndrome, and aging. This review provides a comprehensive overview of SSPCs, including their characteristics, isolation, culture techniques, differentiation pathways, role in tissue regeneration. Additionally, we highlight recent advances cell- tissue-based therapies, SSPC transplantation bioengineered organ replacements. The challenges translating research into effective clinical therapies are also discussed, alongside proposed solutions future directions.
Language: Английский
Citations
0
PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(2), P. e1011586 - e1011586
Published: Feb. 6, 2025
Tissue maintenance is underpinned by resident stem cells whose activity modulated microenvironmental cues. Using Drosophila as a simple model to identify regulators of cell behaviour and survival in vivo , we have identified novel connections between the conserved transmembrane proteoglycan Syndecan, nuclear properties function. In midgut, Syndecan depletion intestinal results their loss from tissue, impairing tissue renewal. At cellular level, alters shape, causes lamina invaginations DNA damage. second developing brain, live imaging revealed that neural envelope remodelling defects which arise upon division. Our findings reveal new role for diverse types.
Language: Английский
Citations
0