Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 193, P. 112468 - 112468

Published: May 28, 2024

Aged sarcopenia is characterized by loss of skeletal muscle mass and strength, mitochondrial dysregulation in myocyte considered as a major factor. Here, we aimed to analyze the effects peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) on reactive oxygen species (ROS) nuclear factor erythroid 2-related 2 (Nrf2) aged muscles.

Language: Английский

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Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics

Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1647 - 1647

Published: Oct. 8, 2024

The most prevalent reason for vision impairment in aging inhabitants is age-related macular degeneration (AMD), a posterior ocular disease with poor understanding of the anatomic, genetic, and pathophysiological progression disease. Recently, new insights exploring role atrophic changes retinal pigment epithelium, extracellular drusen deposits, lysosomal lipofuscin, various genes have been investigated AMD. Hence, this review explores incidence risk factors AMD, such as oxidative stress, inflammation, complement system, involvement bioactive lipids their angiogenesis. In addition to intravitreal anti-vascular endothelial growth factor (VEGF) therapy other therapeutic interventions oral kinase inhibitors, photodynamic, gene, antioxidant therapy, well benefits drawbacks AMD treatment options, strategic drug delivery methods, including routes focus on pharmacokinetics, are investigated. Further, recent advancements nanoformulations polymeric lipid nanocarriers, liposomes, etc., intended pros cons too summarized. Therefore, purpose give researchers an pathophysiology, emphasis angiogenesis, function lipids, options. Additionally, options that development system(s) via several can aid advancement choices.

Language: Английский

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The Role of Dietary Lipids in Cognitive Health: Implications for Neurodegenerative Disease

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3250 - 3250

Published: Dec. 14, 2022

Neurodegenerative diseases are a group of disorders characterised by progressive loss brain function. The most common these is Alzheimer’s disease, form dementia. Intake macro- and micro-nutrients impacts function, including memory, learning, mood, behaviour. Lipids, particularly phospholipids sphingolipids, crucial structural components neural tissues significantly affect cognitive importance functional foods in preventing cardiovascular disease well-documented the current literature. However, significance such for central nervous system health neurodegenerative less recognized. Gut microbiome composition affects dietary lipids known to influence gut health. Thus, this review will discuss different sources their effect on functioning interaction with context disease.

Language: Английский

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Influence of Mediterranean Diet and Incidence of Global Warming on Food Habits and Plant Growth in Northern Mediterranean Latitudes: Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 677 - 677

Published: Feb. 14, 2025

Climate change has consequences for farming, food diversity and availability, diet habits. There is now evidence that the Mediterranean climate rapidly spreading to Northern European latitudes. This narrative review aims identify relevant studies related could favor progression of in northern latitudes Europe, mainly France, predict what these changes on human be, especially using concept diet, with subsequent impacts health, eating was realized by consulting PubMed, Scopus, Science Direct, Google Scholar databases. The key points developed this are as follows: investigating a healthy supporting health benefits perspectives; similarities other places world at same latitudes; resulting plant growth, habits; perspectives need societal adaptations populations towards agriculture, food, cooking changes. As facilitates development new farming practices more or fewer environmental impacts, growth plants highest such olive trees, pomegranates, almonds, already begun economic reasons. In near future, besides interests, will consumption several products associated context, producers consumers play major roles.

Language: Английский

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Oxysterols, age-related-diseases and nutritherapy: focus on 7-ketocholesterol and 7β-hydroxycholesterol

Prostaglandins & Other Lipid Mediators, Journal Year: 2025, Volume and Issue: unknown, P. 106993 - 106993

Published: April 1, 2025

Language: Английский

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Oxysterols in Vascular Cells and Role in Atherosclerosis

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 213 - 229

Published: Dec. 1, 2023

Language: Английский

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Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol – Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue

Current Research in Toxicology, Journal Year: 2024, Volume and Issue: 6, P. 100153 - 100153

Published: Jan. 1, 2024

On murine N2a cells, 7-ketocholesterol induced an oxiapotophagic mode of cell death characterized by oxidative stress (reactive oxygen species overproduction on whole cells and at the mitochondrial level; lipid peroxidation), apoptosis induction (caspase-9, −3 −7 cleavage, PARP degradation) autophagy (increased ratio LC3-II / LC3-I). Oxidative was strongly attenuated diphenyleneiodonium chloride which inhibits NAD(P)H oxidase. Mitochondrial peroxisomal morphological functional changes were also observed. Down regulation PDK1 Akt signaling pathways as well GSK3 Mcl-1 Nrf2 simultaneously observed in 7-ketocholesterol-induced oxiapoptophagy. These events prevented α-linolenic acid, eicosapentaenoic docosahexaenoic oleic acid α-tocopherol. The inhibition cytoprotection LY-294002, a PI3-K inhibitor, demonstrated essential role rescue. rupture oxiapoptophagy associated with important modifications glutathione peroxidase, superoxide dismutase catalase activities peroxidase-1, dismutase-1 level expression. counteracted mercaptosuccinic peroxidase showed this enzyme Altogether, our data support that reactivation α-tocopherol are to prevent 7KC-induced

Language: Английский

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Lipid droplets dependent or independent cytoprotective activities of unsaturated fatty acids, Lorenzo’s oil and sulfo-N-succinimidyl oleate on 7-ketocholesterol-induced oxidative stress, organelle dysfunction and cell death on 158N and ARPE-19 cells: Cell targets and benefits of sulfo-N-succinimidyl oleate

Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100195 - 100195

Published: Jan. 1, 2024

7-ketocholesterol is a cytotoxic oxysterol which frequently increased in many chronic inflammatory and age-related diseases. Thus, the inhibition of toxicity major challenge to treat these 158 N oligodendrocytes were used evaluate cytoprotective effects lipids: omega-3 −9 fatty acids (α-linolenic acid (C18:3n-3), eicosapentaenoic (C20:5n-3), docosahexaenoic (C22:6n-3), erucic (C22:1n-9) oleic (C18:1n-9)), Lorenzo's oil (a mixture acid, 4:1) sulfo-N-succinimidyl oleate (SSO, synthetic derivative acid). On cells, ability molecules inhibit 7KC-induced oxiapoptophagy (plasma membrane alteration, loss ΔΨm, peroxisomal dysfunction, reactive oxygen species overproduction, induction apoptosis autophagy) determined. ARPE-19 epithelial retinal cells also effect SSO on cell death. Unlike oil, had no over wide range concentrations. Noteworthy, unlike oxiapoptophagy, caspase-dependent mode death not associated with an accumulation lipid droplets. In addition, prevented oxidative stress These different characteristics make it possible envisage its use for therapeutic purposes diseases where levels are without eventual secondary side due droplets formation.

Language: Английский

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Characterization of Silybum marianum and Silybum eburneum seed oils: Phytochemical profiles and antioxidant properties supporting important nutritional interests

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0304021 - e0304021

Published: June 14, 2024

Milk thistle seed oil is still not a well-known edible oil. Silybum marianum (milk thistle), present in several countries and the only known representative of genus . However, eburneum , which an endemic plant Spain, Kenya, Morocco, Algeria, Tunisia, considered marginalized species. The work first report that gives information on lipid phenolic profiles Tunisian S compared to those In addition, antioxidant properties these oils were determined with DPPH, FRAP, KRL assays, their ability prevent oxidative stress was human monocytic THP-1 cells. These are characterized by high amounts unsaturated fatty acids; linoleic acid oleic most abundant. Campesterol, sitosterol, stigmasterol, β-amyrin major phytosterols identified. α-tocopherol predominant tocopherol found. also contain significant compounds. diversity richness acids, compounds, tocopherols associated activities revealed assays. cells, powerfully reduced induced 7-ketocholesterol 7β-hydroxycholesterol, two strongly pro-oxidant oxysterols often at increased levels patients age-related diseases. therefore important sources bioactive molecules nutritional interest diseases, frequency increasing all due length life expectancy.

Language: Английский

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Redoxification (of the Organism) Through Diet and Supplementation with a Focus on Natural Polymeric Redox Modulators

Current Pharmacology Reports, Journal Year: 2024, Volume and Issue: 10(2), P. 85 - 95

Published: March 26, 2024

Language: Английский

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