Frontiers in Aging,
Journal Year:
2025,
Volume and Issue:
5
Published: Jan. 7, 2025
Aging
is
a
complex
process
marked
by
various
changes
at
both
cellular
and
systemic
levels,
impacting
the
functioning
lifespan
of
organisms.
Over
time,
researchers
have
pinpointed
several
significant
hallmarks
aging
that
lead
to
gradual
deterioration
tissue
function,
regulation,
homeostasis
associated
with
in
humans.
Despite
this,
intricate
interactions
cumulative
effects
these
are
still
mostly
uncharted
territory.
Understanding
this
web
major
challenge
Geroscience,
yet
it
crucial
for
developing
effective
strategies
promote
healthy
aging,
reduce
medical
costs,
ensure
sustainability
health
systems.
Gaining
insights
area
essential
creating
interventions
can
slow
process,
enhance
healthspan,
decrease
likelihood
age-related
diseases.
The
integration
knowledge
from
fields
concerning
middle-aging
nitric
oxide
(NO)-mediated
hypovascularity
hypoxia
hemodynamic
hypothesis
points
systems-based
approach
biological
aging.
Key
evidence
suggests
connection
between
endocrine
system
(specifically
sex
hormones),
endogenous
NO
deficiency,
vascular
system,
which
serves
as
network
microvascular
structures
perfusion
functions
level.
These
processes
also
involve
oxidative
stress
inflammation
triggered
hypoxia.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 3952 - 3952
Published: April 22, 2025
Cancer-associated
cachexia
(CAC),
also
known
as
wasting
syndrome,
is
a
systemic
condition
that
affects
multiple
tissues
and
organs
via
variety
of
metabolic
pathways.
Systemic
inflammation,
progressive
weight
loss,
depletion
adipose
tissue,
skeletal
muscle
impairment
are
some
the
hallmark
features
cachexia.
Despite
various
studies
on
clinical
CAC,
complexity
syndrome
continues
to
pose
significant
challenges
in
practice,
leading
late
diagnoses
absence
standardised
treatment.
Men
women
respond
differently
which
may
be
prompted
by
pre-existing
physiologic
sex
differences.
This
review
presents
sexual
dimorphism
associated
with
pathways
involved
CAC.
A
comprehensive
understanding
these
could
drive
research
prioritise
inclusion
more
females
related
order
achieve
personalised
sex-based
therapeutic
approaches
and,
consequently,
enhance
treatment
efficacy
better
patient
outcomes.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: May 17, 2025
Aortic
aneurysm
is
one
of
the
causes
cardiovascular
disease-related
death,
posing
a
significant
challenge
to
global
healthcare.
Understanding
burden
aortic
crucial
for
formulating
effective
public
health
intervention
policies
and
allocating
resources.
The
study
aims
assess
global,
regional,
national
burden,
trend,
inequalities
aneurysm.
aneurysm-associated
mortality,
disability-adjusted
life-years
(DALYs),
age-standardized
mortality
rate
(ASMR),
(ASDR),
their
average
annual
percentage
change
(AAPC)
were
estimated
based
on
population-based
study,
Global
Burden
Diseases,
Injuries,
Risk
Factors
Study
(GBD)
2021.
was
analyzed
across
204
countries
territories
from
1990
2021,
stratified
by
sex,
sociodemographic
index
(SDI),
further
predicted
2045.
ASMR
decreased
2.54
per
100,000
population
in
1.86
with
an
AAPC
-0.99%.
ASDR
declined
48.79
36.54
-0.90%.
most
decline
observed
among
males
(-1.14%
vs.
-0.68%
year).
increased
considerably,
especially
low-middle
SDI
(1.29%
year),
while
it
dropped
particularly
high
(-1.65%
Notably,
though
number
DALYs
continue
rising,
projected
decrease
annually
from,
values
1.92
40.38
2045,
respectively.
relative
individuals
since
1990,
along
prominent
related
ASDR.
aneurysm-related
higher
those
living
regions
SDI.
BMC Pregnancy and Childbirth,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Aug. 13, 2024
There
are
many
sex-specific
factors
affecting
myocardial
infarction
(MI)
outcomes
in
males
and
females.
This
study
aimed
to
evaluate
the
relationship
between
reproductive
cardiovascular
women
after
ST-elevation
MI.
retrospective
cohort
was
initiated
2016–2017
at
Chamran
Hospital,
Isfahan,
Iran.
One
hundred
eighty
with
a
diagnosis
of
MI
were
followed
up
for
3
years,
any
occurrence
events
(CVs)
recorded.
All
information
regarding
recorded
via
questionnaire.
compared
without
adverse
using
sample
t
test,
chi-square
multiple
backward
logistic
regression
analysis.
SPSS
version
24
used
conduct
all
analyses.
Sixty-four
mean
age
65.81
±
13.14
years
experienced
CV
events,
116
65.51
10.88
did
not
experience
events.
A
history
ischemic
heart
disease
diabetes
mellitus
more
prevalent
(P
=
0.024
P
0.019).
After
adjusting
mellitus,
oral
contraceptive
pill
(OCP)
usage
than
(60.9%
vs.
40.4%,
0.008).
greater
chance
OCP
(OR
3.546,
0.038)
lower
menarche
0.630,
0.009)
longer
breastfeeding
duration
0.798,
0.041)
according
models.
Based
on
this
study,
consumption
is
risk
factor,
while
older
protective
STEMI.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 8, 2024
Cardiovascular
disease
remains
a
major
global
health
concern,
with
atherosclerosis
(AS)
being
significant
contributor.
Vulnerable
plaques
play
critical
role
in
acute
cardiovascular
events.
Syndecan-1
(SDC-1),
vital
membrane
proteoglycan
the
vascular
endothelial
glycocalyx,
is
believed
to
be
associated
plaque
progression.
However,
its
precise
relationship
severity
and
vulnerability
of
atherosclerotic
unclear.
This
study
aimed
investigate
SDC-1
expression
potential
correlation
ApoE
Viruses,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1902 - 1902
Published: Dec. 10, 2024
Arthropod-borne
viral
diseases
are
acute
febrile
illnesses,
sometimes
with
chronic
effects,
that
can
be
debilitating
and
even
fatal
worldwide,
affecting
particularly
vulnerable
populations.
Indigenous
communities
face
not
only
the
burden
of
these
but
also
cardiovascular
complications
worsened
by
urbanization.
A
cross-sectional
study
was
conducted
in
an
population
Northeast
Region
Brazil
to
explore
association
between
arboviral
infections
(dengue,
chikungunya,
Zika)
cardiac
biomarkers,
including
cardiotrophin
1,
growth
differentiation
factor
15,
lactate
dehydrogenase
B,
fatty-acid-binding
protein
3,
myoglobin,
N-terminal
pro-B-type
natriuretic
peptide,
troponin
I,
big
endothelin
creatine
kinase-MB,
along
clinical
anthropometric
factors.
The
included
174
individuals
from
Fulni-ô
community,
a
median
age
47
years
(interquartile
range
39.0
56.0).
High
rates
previous
exposure
dengue,
Zika
were
observed
(92.5%,
78.2%,
95.4%
anti-IgG,
respectively),
while
(anti-IgM)
remained
low.
biomarkers
linked
(especially
elderly),
obesity,
kidney
disease,
or
recent
chikungunya.
This
pioneers
use
Luminex
xMAP
technology
reveal
inflammatory
classical
arboviruses
undergoing
