Natural Product Communications,
Journal Year:
2024,
Volume and Issue:
19(9)
Published: Sept. 1, 2024
Objective:
Buyang-Huanwu
Decoction
is
often
used
as
an
adjuvant
therapy
for
ischemic
stroke
in
clinical
practice.
At
the
same
time,
various
laboratories
have
found
that
it
has
potential
to
treat
heart
failure,
lower
extremity
varicose
veins,
pulmonary
hypertension,
fibrosis,
and
hyperlipidemia.
Previous
studies
our
laboratory
different
concentrations
of
ethanol
were
separate
polar
components
decoction,
therapeutic
effects
each
group
on
fibrosis
hyperlipidemia
different.
Therefore,
we
analyzed
explored
Buyang
Huanwu
decoction
its
products.
Methods:
The
isolated
obtained
by
treatment
with
absolute
ethanol,
30%
(v/v),
50%
75%
90%
(v/v)
UPLC-MS.
Results:
separation
method
could
well
Decoction,
simply
enrich
carbohydrates,
organic
acids,
phenylpropanoid
compounds,
lipids,
nucleotides,
lignans.
Conclusions:
products
treated
potentials.
high
content
eluate
good
osteoarthritis
bone
loss,
while
precipitate
are
more
likely
be
related
glucose
lipid
metabolism
disorders
cardiovascular
diseases.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 20, 2024
Significant
advances
in
chemotherapy
drugs
have
reduced
mortality
patients
with
malignant
tumors.
However,
chemotherapy-related
cardiotoxicity
increases
the
morbidity
and
of
patients,
has
become
second
leading
cause
death
after
tumor
recurrence,
which
received
more
attention
recent
years.
Arrhythmia
is
one
common
types
chemotherapy-induced
cardiotoxicity,
a
new
risk
related
to
treatment,
seriously
affects
therapeutic
outcome
patients.
Traditional
Chinese
medicine
experienced
thousands
years
clinical
practice
China,
accumulated
wealth
medical
theories
treatment
formulas,
unique
advantages
prevention
diseases.
may
reduce
arrhythmic
toxicity
caused
by
without
affecting
anti-cancer
effect.
This
paper
mainly
discussed
pathogenesis
secondary
chemotherapeutic
drug-induced
arrhythmia
(CDIA),
summarized
studies
on
compounds,
Combination
Formula
injection
that
be
beneficial
intervention
CDIA
including
atrial
fibrillation,
ventricular
sinus
bradycardia,
order
provide
reference
for
arrhythmias.
Doxorubicin
(DOX)
is
a
potent
anticancer
drug;
however,
it
associated
with
significant
cardiotoxicity.
CDC20
an
E3
ubiquitin
ligase
that
plays
role
in
cell
cycle
progression
and
apoptosis
various
types
of
cancers.
The
involvement
DOX-induced
cardiotoxicity
(DIC)
poorly
understood.
Hence,
this
study
aimed
to
explore
the
potential
development
DIC
assess
whether
influences
antitumor
effects
DOX.
H9C2
cells
were
treated
DOX,
followed
by
transcriptomic
analysis
identify
differentially
expressed
genes.
C57BL/6
mice
DOX
for
4
weeks
after
tail
vein
injection
myocardial-specific
knockout
mice,
AAV9-cTNT-(si)
CDC20,
or
intraperitoneal
apcin.
Cardiac
function
pathological
changes
evaluated
echocardiography
staining,
respectively.
influence
on
tumor
inhibition
was
assessed
tumor-bearing
mice.
In
vitro
involved
treating
cardiomyocytes
Ad-CDC20
adenovirus
proteomic
ubiquitination-related
assays
downstream
ubiquitinated
proteins.
Additionally,
we
investigated
effect
CCDC69
CDC20-mediated
protection
against
using
shRNA.
Transcriptome
revealed
effectively
suppressed
expression
CDC20.
Cardiomyocyte-specific
overexpression
mouse
model
myocardial
injury
mitigated
cardiomyocyte
apoptosis,
inflammation,
fibrosis,
atrophy.
Our
mechanistic
investigation
attenuates
downregulating
expression.
Moreover,
cardiomyocyte-specific
had
no
therapeutic
efficacy
tumors.
findings
indicate
safeguards
heart
modulating
degradation
without
compromising
Cardiovascular Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 6, 2025
Abstract
Doxorubicin
(DOX)-induced
cardiotoxicity
(DIC)
is
known
to
be
associated
with
reduction
of
cardiac
protein
kinase
C
epsilon
(PKC-ε).
PKC-ε
promotes
cell
survival
and
protects
hearts
against
various
stresses.
However,
it
unclear
whether
or
not
the
in
expression
plays
a
causal
role
DIC
particular
potential
underlying
mechanism
whereby
may
protect
DIC.
C57BL/6
mice
(8–10-week-old)
were
either
treated
DOX
administered
intraperitoneally
for
duration
4
weeks
produce
cardiotoxicity,
untreated
which
received
same
volume
saline.
In
vitro,
neonatal
rat
ventricle
cardiomyocytes
exposed
24
h
absence
presence
adenovirus
overexpressing
PKC-ε.
Cardiomyocytes
subgroup
sirtuin-1
(SIRT1)
selective
inhibitor
Ex527.
Four
after
DOX,
contractile
function
was
decreased
concomitant
increased
serum
CK-MB
LDH
levels
as
well
increases
Bax-to-Bcl-2
ratio
Cleaved
Caspase
3
proteins
expression,
while
Sirt1
expressions
significantly
decreased.
reduced
cardiomyocyte
SIRT1
viability,
release
oxidative
stress
apoptosis.
These
changes
attenuated
by
overexpression
IP
study
showed
that
could
directly
indirectly
bind
cardiomyocytes,
effects
further
canceled
inhibition.
conclusion,
activating
represent
major
heart
DOX-induced
apoptosis
stress.
Graphical
Dox
induces
via
inhibiting
PKC-epsilon/Sirt1
signaling
can
reversed
PKC-epsilon
overexpression.
Antioxidants and Redox Signaling,
Journal Year:
2023,
Volume and Issue:
41(1-3), P. 1 - 23
Published: Sept. 27, 2023
Aims:
The
relationship
between
the
gut
microbiota
and
cardiovascular
system
has
been
increasingly
clarified.
Fecal
transplantation
(FMT),
used
to
improve
microbiota,
applied
clinically
for
disease
treatment
great
potential
in
combating
doxorubicin
(DOX)-induced
cardiotoxicity.
However,
application
of
FMT
field
its
molecular
mechanisms
are
poorly
understood.
