Toxicology and Applied Pharmacology, Journal Year: 2023, Volume and Issue: 482, P. 116791 - 116791
Published: Dec. 14, 2023
Language: Английский
Cancers, Journal Year: 2023, Volume and Issue: 15(8), P. 2195 - 2195
Published: April 7, 2023
Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian that digests damaged organelles misfolded proteins lysosomal degradation, is closely associated with metabolism cells, acting as meter cellular ATP levels. In this review, we discuss the glycolytic biosynthetic pathways their impact on carcinogenesis autophagy pathway. addition, these metabolic lung cancer.
Language: Английский
Citations
37
Biology, Journal Year: 2023, Volume and Issue: 12(2), P. 302 - 302
Published: Feb. 14, 2023
Glioblastoma multiforme (GBM) is one of the deadliest cancers. Temozolomide (TMZ) most common chemotherapy used for GBM patients. Recently, combination strategies have had more effective antitumor effects and focus on slowing down development resistance. A TMZ cholesterol-lowering medications (statins) currently under investigation in vivo clinical trials. In our current investigation, we a triple-combination therapy TMZ, Simvastatin (Simva), acetylshikonin, investigated its apoptotic mechanism cell lines (U87 U251). We viability, apoptosis, reactive oxygen species, mitochondrial membrane potential (MMP), caspase-3/-7, acridine orange (AO) immunoblotting autophagy assays. Our results showed that TMZ/Simva/ASH induced significantly apoptosis compared to Simva, ASH, TMZ/Simva treatments cells. Apoptosis via treatment damage (increase ROS, decrease MMP) caspase-3/7 activation both lines. Compared all single treatment, increased positive acidic vacuole organelles. further confirmed increase AVOs during was due partial inhibition flux (accumulation LC3β-II p62 degradation) also TMZ/Simva/ASH-induced death depended flux, as Finally, potentially depends an Bax expression might open new avenues GBM, but investigations are required better identification mechanisms.
Language: Английский
Citations
24
Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 99, P. 24 - 44
Published: Feb. 1, 2024
Autophagy, a self-degradative process vital for cellular homeostasis, plays significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, cancer development, with specific emphasis on how obesity-driven changes affect regulation of autophagy subsequent implications risk. The burgeoning epidemic obesity underscores relevance this research, particularly given established links various cancers. Our exploration delves into hormonal influence, notably INS (insulin) LEP (leptin), interactions. Further, we draw attention latest findings molecular factors linking cancer, including changes, altered metabolism, secretory autophagy. We posit that targeting modulation may offer potent therapeutic approach obesity-associated pointing promising advancements nanocarrier-based targeted therapies modulation. However, also recognize challenges inherent these approaches, concerning their precision, control, dual roles can play cancer. Future research directions include identifying novel biomarkers, refining therapies, harmonizing approaches precision medicine principles, thereby contributing more personalized, effective treatment paradigm obesity-mediated
Language: Английский
Citations
15
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 710, P. 149910 - 149910
Published: April 7, 2024
Language: Английский
Citations
10
Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Cell Stress and Chaperones, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
7
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 11, 2024
Language: Английский
Citations
4
The Egyptian Heart Journal, Journal Year: 2025, Volume and Issue: 77(1)
Published: March 10, 2025
Abstract Background Cardiomyopathy is a heterogeneous group of myocardial disorders characterized by structural and functional abnormalities the heart muscle. It classified into primary (genetic, mixed, or acquired) secondary categories, resulting in various phenotypes including dilated, hypertrophic, restrictive patterns. Hypertrophic cardiomyopathy, most common form, can cause exertional dyspnea, presyncope, sudden cardiac death. Dilated cardiomyopathy typically presents with failure symptoms, while rarer often associated systemic diseases. Diagnosis involves comprehensive evaluation history, physical examination, electrocardiography, echocardiography. Treatment options range from pharmacotherapy lifestyle modifications to implantable cardioverter-defibrillators transplantation refractory cases. Main body Anthracyclines, particularly doxorubicin, have emerged as crucial components cancer treatment, demonstrating significant antitumor activity across malignancies. These drugs become standard numerous chemotherapy regimens, improving patient outcomes. However, their use severe cardiotoxicity, failure. The mechanisms anthracycline action toxicity are complex, involving DNA damage, iron-mediated free radical production, disruption cardiovascular homeostasis. Doxorubicin-induced (DIC) complication treatment poor prognosis limited effective treatments. pathophysiology DIC multiple mechanisms, oxidative stress, inflammation, mitochondrial calcium homeostasis disorder. Despite extensive research, no for established currently available. Dexrazoxane only FDA-approved protective agent, but it has limitations. Recent studies explored potential therapeutic approaches, natural drugs, endogenous substances, new dosage forms, herbal medicines. lack experimental models incorporating pre-existing limits understanding efficacy. Conclusion Cardiomyopathy, whether secondary, poses clinical challenge due its varying etiologies advanced stages. Anthracycline-induced chemotherapy, doxorubicin being notable contributor. advancements therapies, cardiotoxic effects anthracyclines necessitate further investigation preventive strategies interventions improve
Language: Английский
Citations
0
Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 277 - 277
Published: April 5, 2025
Doxorubicin (DOX) is used for the treatment of various malignancies, including leukemias, lymphomas, sarcomas, and bladder, breast, gynecological cancers in adults, adolescents, children. However, DOX causes severe side effects patients, such as cardiotoxicity, which encompasses heart failure, arrhythmia, myocardial infarction. DOX-induced cardiotoxicity (DIC) based on combination nuclear-mediated cardiomyocyte death mitochondrial-mediated death. Oxidative stress, altered autophagy, inflammation, apoptosis/ferroptosis represent main pathogenetic mechanisms responsible DIC. In addition, vitro vivo models DIC sirtuins (SIRT), especially, SIRT 1 are reduced, this event contributes to cardiac damage. fact, inhibits reactive oxygen species NF-kB activation, thus improving oxidative stress remodeling. Therefore, recovery during may a therapeutic strategy limit progression. Natural products, i.e., polyphenols, well nano formulations iron chelators, other potential compounds experimented with At present, few clinical trials available confirm efficacy these products The aim review description pathophysiology drug targets alleviate
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 761, P. 110140 - 110140
Published: Sept. 6, 2024
Language: Английский
Citations
3