U(VI)
pollution
has
already
led
to
serious
harm
the
environment
and
human
health
with
increase
of
activities.
The
viability
RAW264.7
cells
was
assessed
under
various
concentration
stress
for
24
48
hours.
reactive
oxygen
species
(ROS),
mitochondrial
membrane
potential
(MMP),
superoxide
dismutase
(SOD)
activities
were
measured.
results
showed
that
decreased
cell
activity,
induced
intracellular
ROS
production,
abnormal
MMP,
increased
SOD
activity.
flow
cytometry
Annexin-V/PI
double
labeling
demonstrated
rate
late
apoptosis
concentration,
resulting
in
Bcl-2
expression
Bax
expression.
morphology
dramatically
changed
after
h
exposure,
including
evident
bubble
phenomenon.
Besides,
also
proportion
LDH
releases
GSDMD,
Ras,
p38,
JNK,
ERK1/2
protein
expression,
which
indicated
MAPK
pathway
involved.
Therefore,
ultimately
pyroptosis
cells.
This
study
offered
convincing
proof
immunotoxicity
established
theoretical
framework
further
fundamental
studies
on
toxicity.
Biochar,
Journal Year:
2024,
Volume and Issue:
6(1)
Published: March 1, 2024
Abstract
Soil
contamination
by
uranium
presents
a
burgeoning
global
environmental
concern,
exerting
detrimental
effects
on
both
agricultural
production
and
soil
health.
Biochar,
carbonaceous
material
derived
from
biomass
pyrolysis,
exhibits
considerable
potential
for
remediating
uranium-contaminated
soils.
However,
comprehensive
review
of
the
biochar
fate
accumulation
in
soil–plant
systems
remains
conspicuously
absent.
In
this
paper,
sources
are
reviewed,
impact
immobilization
detoxification
is
analyzed.
We
reviewed
status
soils
globally
found
that
mining
activities
currently
main
sources.
Further
meta-analysis
revealed
addition
significantly
reduced
bioavailability
shoot
accumulation,
their
effect
value
58.9%
(40.8–76.8%)
39.7%
(15.7–63.8%),
respectively.
Additionally,
enhances
microenvironment,
providing
favourable
conditions
promoting
plant
growth
reducing
mobility.
focused
mechanisms
governing
interaction
between
uranium,
emphasising
roles
played
surface
complexation,
reduction,
ion
exchange,
physical
adsorption.
The
modification
intensifying
these
can
promote
immobilisation
Finally,
alleviates
oxidative
stress
reduces
tissues,
thereby
mitigating
adverse
development.
Overall,
our
highlights
capacity
to
remediate
through
diverse
mechanisms,
valuable
insights
sustainable
remediation.
Highlights
Biochar
mobility
variety
including
limits
its
plants.
Modified
has
been
shown
enhance
effectiveness
immobilising
uranium.
application
not
only
promotes
remediation
but
also
improves
quality.
Graphical
Current Environmental Health Reports,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Jan. 18, 2025
Zinc
is
an
essential
micronutrient
with
a
myriad
of
key
roles
in
human
health.
This
review
summarizes
mechanistic
data
supporting
the
protective
effects
zinc
on
metal
toxicity
and
discusses
framework
for
interventional
clinical
trial
supplementation
within
exposed
Native
American
community.
Many
metals
have
common
underlying
mechanisms
that
contribute
to
adverse
health
effects.
Studies
demonstrate
multiple
aspects
can
be
attributed
disruption
zinc-dependent
functions.
Multiple
lines
evidence
suggest
may
confer
protection
against
populations
mixed-metal
exposures.
Thinking
mechanism-informed
intervention
study
test
potential
benefits
while
maintaining
culturally
responsive
research
approach.
The
current
knowledge
diverse
interactions,
coupled
strong
context
toxic
exposures,
supports
hypothesis
mitigate
impact
exposures
chronic
mixed
low
status.
Biology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 58 - 58
Published: Jan. 13, 2025
Phytoremediation
technology
is
viewed
as
a
potential
solution
for
addressing
soil
uranium
contamination.
Sudan
grass
(Sorghum
sudanense
(Piper)
Stapf.),
noted
its
robust
root
structure
and
resilience
to
heavy
metals,
has
garnered
significant
attention.
This
paper
investigates
strain
of
uranium-tolerant
bacterium,
B6,
obtained
from
the
inter-root
environment
native
plants
in
contaminated
with
tailings.
The
bacterium
was
identified
Bacillus
cereus.
Genomic
analyses
assessment
tolerance-promoting
properties
showed
that
B6
not
only
exhibited
high
tolerance,
but
also
possessed
beneficial
such
phosphorus
solubilization
iron-producing
carriers.
In
this
study,
we
used
an
inoculant
combination
germination
potting
experiments.
findings
demonstrated
cereus
could
substantially
mitigate
adverse
effects
stress
on
grass,
boost
plant’s
antioxidant
response,
significantly
increase
length
dry
biomass
facilitate
accumulation
roots,
well
translocation
aboveground
portions.
study
PGPB
can
enhance
effect
plant
become
uranium-rich
plant,
which
provides
important
scientific
basis
application
prospect
use
microbial-assisted
remediation
treat
uranium-contaminated
soil.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
293, P. 118043 - 118043
Published: March 1, 2025
Uranium,
a
naturally
occurring
element,
is
predominantly
recognized
for
its
role
as
fuel
in
both
civilian
and
military
energy
sectors.
Concerns
have
been
raised
regarding
the
adverse
environmental
impacts
health
risks
associated
with
uranium
mining
due
to
exposure
it
causes.
Such
leads
systemic
toxicity,
affecting
pulmonary,
hepatic,
renal,
reproductive,
neurological,
bone
health.
This
review
identifies
significant
research
gaps
detoxification
methods
contamination
recommends
further
advancements,
including
genetic
modification
exploration
of
plant
compounds.
A
comprehensive
published
materials
from
diverse
sources
uranium,
various
treatments
hazardous
on
human
body,
was
conducted.
Additionally,
PRISMA
analysis
performed
this
study.
emphasizes
importance
collaboration
formulation
research-informed
regulations
effectively
safeguard
vulnerable
communities
consequences
contamination.
Public
discourse
often
significance
radiotoxicity;
however,
non-radioactive
chemotoxicity
has
identified
risk
factor
exposures,
contingent
upon
species,
enrichment,
route.
Given
these
serious
consequences,
several
are
being
investigated
ameliorate
toxicity.
In
response
concerns,
techniques,
such
phytomedicinal
treatments,
biochemical
approaches,
chelation
therapy,
minimize
effects
body.
