Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215130 - 215130

Published: April 10, 2023

Language: Английский

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Advancements in ESIPT probe research over the past three years based on different fluorophores

Dyes and Pigments, Journal Year: 2024, Volume and Issue: 224, P. 111994 - 111994

Published: Feb. 3, 2024

Language: Английский

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Research progress of organic fluorescent probes for lung cancer related biomarker detection and bioimaging application

Talanta, Journal Year: 2024, Volume and Issue: 272, P. 125766 - 125766

Published: Feb. 8, 2024

Language: Английский

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Alkaline phosphatase activatable near-infrared fluorescent probe for in-situ diagnosis of cholestatic liver injury

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135896 - 135896

Published: May 1, 2024

Language: Английский

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Recent Progress on NIR Fluorescent Probes for Enzymes

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 5922 - 5922

Published: Sept. 12, 2022

The majority of diseases’ biomarkers are enzymes, and the regulation enzymes is fundamental but crucial. Biological system disorders diseases can result from abnormal enzymatic activity. Given biological significance researchers have devised a plethora tools to map activity particular in order gain insight regarding their function distribution. Near-infrared (NIR) fluorescence imaging studies on may help better understand roles living systems due natural advantages. We review NIR fluorescent probe design strategies that been attempted by develop sensors these works provided deep intuitive insights into study systems. recent enzyme-activated probes applications summarized, prospects challenges developing discussed.

Language: Английский

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Vision for Ratiometric Nanoprobes: In Vivo Noninvasive Visualization and Readout of Physiological Hallmarks

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7109 - 7134

Published: April 10, 2023

Lesion areas are distinguished from normal tissues surrounding them by distinct physiological characteristics. These features serve as biological hallmarks with which targeted biomedical imaging of the lesion sites can be achieved. Although tremendous efforts have been devoted to providing smart probes capability visualizing at molecular level, majority merely able derive anatomical information interest, and thus not suitable for taking part in vivo quantification biomarkers. Recent advances chemical construction advanced ratiometric nanoprobes (RNPs) enabled a horizon quantitatively monitoring abnormalities vivo. In contrast conventional whose dependency output on single-signal profiles restricts quantitative practices, RNPs designed provide two channels, affording self-calibration opportunity exclude analyte-independent factors outputs address issue. Most encountered several challenges regarding reliability sufficiency obtained data high-performance imaging. this Review, we summarized recent progresses developing highly capabilities deriving maximized interest well adapting themselves complex systems order minimize microenvironmental-induced falsified signals. To better outlook current RNPs, based optical, photoacoustic, magnetic resonance modalities wide range analytes such pH, reactive species, different derivations amino acids included. Furthermore, physicochemical properties major constituents nanosystems analyte recognition mechanisms introduced. Moreover, alterations values signal response time highest value is achieved, included most discussed Review. Finally, future perspectives field discussed.

Language: Английский

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Recent advances of fluorescent probe for the conjugated enzymes closely related to clinical diseases

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 529, P. 216471 - 216471

Published: Jan. 28, 2025

Language: Английский

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Ratiometric fluorescent probe for triphosgene detection and its application in electrospun fluorescent fibers

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 126149 - 126149

Published: April 1, 2025

Language: Английский

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Effects of Daidzein, Tempeh, and a Probiotic Digested in an Artificial Gastrointestinal Tract on Calcium Deposition in Human Osteoblast-like Saos-2 Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1008 - 1008

Published: Jan. 13, 2024

Adequate calcium intake is crucial for the prevention and treatment of bone-related issues. Developing a nutritional source readily bioavailable particularly significant individuals deficient in this essential element at risk developing osteoporosis. This research aimed to evaluate impact tempeh (T), daidzein (D), Lactobacillus acidophilus (LA) within simulated intestinal environment consisting Caco-2 epithelial Saos-2 cells, focusing on their implications bone mineralization mechanisms. In initial phase, bioaccessibility from citrate (CaCt), LA, D, combination D–CaCt–LA (D1:1:1), T–CaCt–LA (T1:1:1) was assessed through digestion simulation. The content both untreated digested samples determined using atomic absorption spectrometry (AAS). subsequent stage, were used induce differentiated enterocyte-like cells. permeable fractions then evaluated culture osteoblast-like Preliminary cellular experiments employed MTT assay assess cytotoxicity. results indicated that analyzed products did not influence deposition extracellular cells cultured without stimulators. combined formulations CaCt, T demonstrated capacity enhance proliferation D1:1:1, LA showed no discernible intracellular accumulation, whereas T1:1:1 reduced deposits. Additionally, mRNA transcripts alkaline phosphatase (ALP) activity levels induction unaffected by products. An examination revealed effect ALP or expression during cell differentiation. Our findings suggest tempeh, daidzein, L. positively However, its combination, might process osteogenic differentiation Nevertheless, study identify any synergistic isoflavones probiotics.

Language: Английский

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Clinical characteristics and risk factors of Helicobacter pylori infection‐associated Sjogren's syndrome

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(10)

Published: Oct. 1, 2023

Abstract Objective Although infectious pathogens are predominant factors for inducing and maintaining immune system disorders, there exist few reports establishing the significant correlation between Helicobacter pylori ( H. ) infection Sjogren's syndrome. This study aims to demonstrate syndrome in patients, highlighting various clinical characteristics risk factors. Methods A single‐center retrospective observational was conducted patients n = 224) admitted from January 1, 2012, February 10, 2021, First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China). All recruited subjects with were only included by validating available medical records online. Results In this study, a total 224 diagnosed Among them, 94 (41.96%) infected . Accordingly, manifestations, serological immunological characteristics, as well gastroscopic biopsy outcomes primary (pSS) reported. The multivariable analysis dry displayed hypergammaglobulinemia (odds ratio [OR], 0.354; 95% confidence interval [CI], 0.189‐0.663), cholesterol (OR, 1.158; CI, 0.856‐1.550), hypertension 0.227; 0.114‐0.455), Female sex 5.778; 1.458‐22.9), anti‐SSA/Ro60 positive 2.384; 1.233‐4.645), γ‐GT 0.99; 0.99‐1.00) alkaline phosphatase 1.00; 0.99–1.00) levels. Conclusion Together, our findings demonstrated that could be independent syndrome, requiring physician's advice future.

Language: Английский

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