Zinc oxide nanoparticles decorated nitrogen doped porous reduced graphene oxide-based hybrid to sensitive detection of hydroxychloroquine in plasma and urine

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 7, 2025

The antimalarial hydroxychloroquine (HCQ) has considered for the treatment of systemic lupus erythematosus. Moreover, HCQ been used as a drug to treat Coronavirus disease (COVID-19). In this work, nitrogen doped porous reduced graphene oxide (NprGO) prepared via environmentally friendly process using Fummaria Parviflora extract. A catalyst based on ZnO nanoparticles-nitrogen (ZnO-NprGO) was by hydrothermal method and characterized. diameter nanoparticles ~22–37 nm, which were inserted between NprGO sheets effectively prevented their aggregation. ZnO-NprGO hybrid had high surface area good electro-catalytic property, suiting determination HCQ. modified carbon paste electrode (CPE)-based sensor operated in wide concentration range 0.07–5.5 μmol L−1 with low limit detection 57 nmol sensitivity 14.175 μA μmol−1 L. Remarkably, ZnO-NprGO/CPE indicated acceptable accuracy, reproducibility, stability. addition, proposed applied biological samples recoveries 92.0–102.5%, relative standard deviations 1.9–4.3%. unique physical structure ZnO-NprGO, well its chemical electrical properties, make it promising interface use sensors nanoelectronic applications.

Language: Английский

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Optimizing the Construction and Activation of 3D-Printed Electrochemical Sensors: An Experimental Design Approach for Simultaneous Electroanalysis of Paracetamol and Caffeine

ACS Omega, Journal Year: 2025, Volume and Issue: 10(1), P. 1131 - 1143

Published: Jan. 6, 2025

This work presents an optimization of the construction, treatment, and activation 3D-printed electrochemical sensors (E-3D). For this, was used a 23-full factorial design examining three key variables at two levels: electrode height, diameter, printing speed. Moreover, it evaluates various physical, chemical, methods to treat activate E-3D surface. The techniques impedance spectroscopy cyclic voltammetry (CV) shows that sequential treatments lead highest treatment efficiency activation. Raman atomic force microscopy characterize untreated treated sensor surfaces. optimal methodology applied electroanalysis paracetamol (PAR) caffeine (CAF) simultaneously using CV differential pulse anodic stripping (DPASV). DPASV measurements reveal limits detection 0.44 0.58 μmol L–1 in 0.5 mol H2SO4 medium for PAR CAF, respectively, with activated sensor. principal achievement this emphasizing critical role surface enhancing performance developed electrodes, thereby advancing technological applications sensors.

Language: Английский

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Emerging Biomedical and Clinical Applications of 3D-Printed Poly(Lactic Acid)-Based Devices and Delivery Systems

Bioengineering, Journal Year: 2024, Volume and Issue: 11(7), P. 705 - 705

Published: July 11, 2024

Poly(lactic acid) (PLA) is widely used in the field of medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing or systematic deposition PLA layers has enabled fabrication customized scaffolds for various biomedical clinical applications. In tissue engineering regenerative medicine, 3D-printed been mostly generate bone scaffolds, typically combination with different polymers ceramics. PLA’s versatility also allowed development drug-eluting constructs controlled release agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, vitamins. Additionally, recently develop diagnostic electrodes, prostheses, orthoses, surgical instruments, radiotherapy devices. provided a cost-effective, accessible, safer means improving patient care through dosimetry guides, well enhancing medical education training models simulators. Overall, widespread use settings expected persistently stimulate innovation revolutionize healthcare delivery.

Language: Английский

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Unraveling the Versatility of Carbon Black – Polylactic Acid (CB/PLA) 3D‐Printed Electrodes via Sustainable Electrochemical Activation

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Commercially available conductive filaments are not designed for electrochemical applications, resulting in 3D printed electrodes with poor behavior, restricting their implementation energy and sensing technologies. The proper selection of an activation method can unlock use advanced applications. In this work, rectangular made from carbon black – polylactic acid (CB/PLA) filament different layouts (grid compact) then activated using a highly reproducible eco‐compatible (EC) treatment. characterized morphological, structural, features to obtain insights into the material properties functionality. Furthermore, influence electrode layout as well conditions studied aiming provide better understanding mechanism driving behavior electrodes. EC enhances performance, provides uniform activity electrode's interface allows manipulation by adjusting duration CB/PLA offer wide stable potential window that benefits water‐based Thus, suitability Zn‐ion batteries is explored, followed application hydroquinone determination water samples.

Language: Английский

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Enhanced electrochemical performance of 3D-printed electrodes via blue-laser irradiation and (electro)chemical treatment

Electrochimica Acta, Journal Year: 2024, Volume and Issue: 506, P. 144995 - 144995

Published: Aug. 31, 2024

Language: Английский

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Electrochemical sensor based on a ZnO-doped graphitized carbon for the electrocatalytic detection of the antibiotic hydroxychloroquine. Application: tap water and human urine

Journal of Applied Electrochemistry, Journal Year: 2023, Volume and Issue: 53(6), P. 1279 - 1294

Published: Jan. 7, 2023

Language: Английский

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New approaches in antibiotics detection: The use of square wave voltammetry

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2023, Volume and Issue: 234, P. 115526 - 115526

Published: June 15, 2023

Language: Английский

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Construction of ANbO3 (A= Na, K)/f-carbon nanofiber composite: Rapid and real-time electrochemical detection of hydroxychloroquine in environmental samples

Environmental Research, Journal Year: 2022, Volume and Issue: 215, P. 114232 - 114232

Published: Aug. 31, 2022

Language: Английский

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3D printing in analytical chemistry—Quo Vadis?

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 453 - 473

Published: Jan. 1, 2025

Language: Английский

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3D-printed electrochemical sensors

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 355 - 391

Published: Jan. 1, 2025

Language: Английский

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