A novel dual-responsive colorimetric/fluorescent probe for the detection of N2H4 and ClO− and its application in environmental analysis and bioimaging

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134105 - 134105

Published: March 21, 2024

Language: Английский

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Engineered hydrogel platform for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

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Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101028 - 101028

Published: March 24, 2024

The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.

Language: Английский

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ROS induced pyroptosis in inflammatory disease and cancer

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 1, 2024

Pyroptosis, a form of caspase-1-dependent cell death, also known as inflammation-dependent plays crucial role in diseases such stroke, heart disease, or tumors. Since its elucidation, pyroptosis has attracted widespread attention from various sectors. Reactive oxygen species (ROS) can regulate numerous cellular signaling pathways. Through further research on ROS and pyroptosis, the level been revealed to be pivotal for occurrence establishing close relationship between two. This review primarily focuses molecular mechanisms tumors inflammatory diseases, exploring key proteins that may serve drug targets linking emerging fields targeting pyroptosis. Additionally, potential future development compounds influence ROS-regulated is anticipated, aiming provide insights anti-tumor anti-inflammatory drugs.

Language: Английский

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A mitochondria-specific NIR fluorescence probe for dual-detection of sulfur dioxide and viscosity in living cells and mice

Analytical Methods, Journal Year: 2024, Volume and Issue: 16(24), P. 3839 - 3846

Published: Jan. 1, 2024

A mitochondria-specific NIR fluorescence probe ( CMBT ) has been constructed for dual-detection of sulfur dioxide (SO 2 and viscosity with high selectivity sensitivity in living cells mice.

Language: Английский

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Dicyanoisophorone-based near-infrared fluorescent probe with large Stokes shift for the monitoring and bioimaging of hypochlorite

Talanta, Journal Year: 2024, Volume and Issue: 274, P. 126063 - 126063

Published: April 5, 2024

Language: Английский

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Raman Spectroscopy for Cell Analysis: Retrospect and Prospect

Talanta, Journal Year: 2024, Volume and Issue: 285, P. 127283 - 127283

Published: Nov. 26, 2024

Language: Английский

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Advancements in small molecule fluorescent probes for the detection of formaldehyde in environmental and food samples: A comprehensive review

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144041 - 144041

Published: March 1, 2025

Language: Английский

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A novel fluorescent probe with a large Stokes shift for rapidly monitoring hypochlorous acid in living cells, zebrafish, and tobacco seedlings

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112836 - 112836

Published: April 1, 2025

Language: Английский

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A Self‐immobilizing PET Tracer for Imaging of H₂O₂ Level in the Brain

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Comprehensive Summary Reactive oxygen species (ROS) are involved in the onset and development of neurodegenerative diseases, such as Alzheimer's disease (AD) Parkinson's (PD). Hydrogen peroxide (H 2 O ), a key type ROS, is overexpressed early stages AD PD progression. Assessing H levels brain considered to be valuable tool for detecting diseases exploring their pathogenesis. In this study, we developed two self‐immobilizing PET tracers ( [ 18 F]HYAS F]HYAT ) based on quinone methide (QM) scaffold non‐invasive imaging brain. Both can respond by forming QM intermediate, which rapidly reacts with nucleophiles. , proper physicochemical properties, able crossing blood‐brain barrier. Increased uptake was observed brains mice treated 1‐methyl‐4‐phenyl‐ l,2,3,6‐tetrahydropyridine (MPTP), indicating that useful tracer

Language: Английский

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