The emerging cause and threats of Arboviral diseases and its control measures: A comprehensive review DOI Open Access
Mayank Raj,

Rishu Raj,

Anshika Kamboj

et al.

International Journal of Mosquito Research, Journal Year: 2024, Volume and Issue: 11(1), P. 92 - 98

Published: Jan. 1, 2024

The recent developments of viral illnesses are vector- borne, such as Chikungunya and dengue fever, other similar diseases, have raised significant global concern. In this paper, we provide a comprehensive overview the existing literature pertaining to transmission, clinical manifestations, diagnostic methods, impact, likelihood future outbreaks associated with these pathogens. Arboviruses difficult identify can cause unexpected consequences. Dengue chikungunya most common arboviruses caused infections worldwide, particularly in tropical subtropical areas. transmission diseases human beings is facilitated by Aedes aegypti albopictus mosquito species. spread mostly responsible for rise cases India. expeditious accurate identification utmost importance effectively managing containing epidemics disease. light lack an available vaccine or targeted pharmaceutical intervention viruses, strategy currently vector control.

Language: Английский

Zr‐MOF Carrier‐Enhanced Dual‐Mode Biosensing Platforms for Rapid and Sensitive Diagnosis of Mpox DOI Creative Commons

Huiyi Yang,

Judun Zheng, Wei Wang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

Dual-mode readout platforms with colorimetric and electrochemiluminescence (ECL) signal enhancement are proposed for the ultrasensitive flexible detection of monkeypox virus (MPXV) in different scenes. A new nanotag, Ru@U6-Ru/Pt NPs is constructed dual-mode by integrating double-layered ECL luminophores nanozyme using Zr-MOF (UiO-66-NH

Language: Английский

Citations

43
Colorimetric and Photothermal Dual-Modal Switching Lateral Flow Immunoassay Based on a Forced Dispersion Prussian Blue Nanocomposite for the Sensitive Detection of Prostate-Specific Antigen DOI

Haijiang Gong,

Shili Gai,

Yuelin Tao

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(21), P. 8665 - 8673

Published: May 9, 2024

Prostate-specific antigen (PSA) is a key marker for prostate cancer diagnosis. The low sensitivity of traditional lateral flow immunoassay (LFIA) methods makes them unsuitable point-of-care testing. Herein, we designed nanozyme by in situ growth Prussian blue (PB) within the pores dendritic mesoporous silica (DMSN). PB was forcibly dispersed into DMSN, leading to an increase exposed active sites. Consequently, atom utilization enhanced, resulting superior peroxidase (POD)-like activity compared that cubic PB. Antibody-modified DMSN@PB nanozymes serve as immunological probes enzymatic-enhanced colorimetric and photothermal dual-signal LFIA PSA detection. After systematic optimization, based on successfully achieves 4-fold amplification signal 7 min through catalytic oxidation chromogenic substrate POD-like activity. Moreover, exhibits excellent conversion ability under 808 nm laser irradiation. Accordingly, signals are introduced improve anti-interference LFIA, exhibiting wide linear range (1–40 ng mL–1) detection limit (0.202 mL–1), which satisfies early level cancer. This research provides more accurate reliable visualization analysis methodology diagnosis

Language: Английский

Citations

14
Aspergillus Mycotoxins: The Major Food Contaminants DOI Creative Commons
Mengyao Xue, Zheng Qu, Antonio Moretti

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Mycotoxins, a category of fungal secondary metabolites, frequently contaminate food products and pose severe threat to human health. Aspergillus, genus fungi, is capable producing mycotoxins, with aflatoxins (AFs) ochratoxins being its principal types. Aspergillus mycotoxins can wide range crops their derivatives, such as maize, wheat, rice, minor cereals, peanuts, thereby threatening feed safety. In the paper, related biosynthesis genes multifaceted pathways these are first discussed in detail, elucidated several global regulators, including growth conditions, oxidative stress, cell signal. Furthermore, how shifts temperature water availability, driven by climate change (including rising temperatures, increased heavy rainfall frequency, prolonged droughts, elevated carbon dioxide levels), key determinants proliferation mycotoxin production explored. Finally, safeguard animal health from detrimental impacts effective convenient analytical techniques management strategies for detection prevention contamination analyzed. Overall, this review provides promising solutions which great significance ensuring security protecting people's lives

Language: Английский

Citations

1
Sensitive colorimetric detection of Vibrio vulnificus based on target-induced shielding against the peroxidase-mimicking activity of CeO2@PtRu nanozyme DOI

Chenjing Xu,

Jinpo Xie,

Lian Yu

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 454, P. 139757 - 139757

Published: May 21, 2024

Language: Английский

Citations

7
Equipmentless point-of-care testing of dengue antibodies using ELISA and smartphones DOI
Diego Mendicino, Christian A. Avalos, Romina Chiaraviglio

et al.

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 255, P. 116666 - 116666

Published: Jan. 5, 2025

Language: Английский

Citations

0
Transient Expression of Zika NS2B Protein Antigen in Nicotiana benthamiana and Use for Arboviruses Diagnosis DOI Creative Commons

Mario Alberto Maestre Herazo,

Daylana R. S. Dantas,

Bruno Bueno‐Silva

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(2), P. 2184 - 2196

Published: Jan. 8, 2025

Zika (ZIKV) and Dengue (DENV) viruses are clinically significant due to their severe neurological hemorrhagic complications. Rapid diagnostics often rely on nonstructural proteins generate specific antibodies. This study aimed produce IgG antibodies from the recombinant ZIKV protein plant-expressed NS2B for arbovirus detection in serum urine samples. The was expressed Nicotiana benthamiana purified chromatographically. Validation of as an antigen indirect immunoassays demonstrated 95% sensitivity 100% specificity IgM/IgG ELISA tests, enabling effective DENV. Notably, r-ZIKV-NS2B identified positive DENV cases but failed detect negatives, suggesting limitations diagnostics. Using a diagnostic medium offers less invasive more practical approach, broadening test applicability. utilized patient-derived samples healthy spiked with exogenous virus. Findings highlight potential ZIKV-NS2B robust diagnosis demonstrate viability plant-based systems production, advancing neglected tropical diseases.

Language: Английский

Citations

0
Overview of dengue diagnostic limitations and potential strategies for improvement DOI
Selvaraj Ayyamperumal,

Anand Ramaian Santhaseela,

Elavarasan Tamilmani

et al.

Diagnosis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Introduction Dengue is a viral infection caused by any one of the four related dengue virus (DENV) serotypes, 1–4. DENV single-stranded RNA belonging to genus Flavivirus . can cause range symptoms, from mild severe life-threatening illness. Currently, treatment for limited supportive care, with better outcomes achieved through early diagnosis. The WHO has suggested that mortality be reduced nearly zero implementing appropriate clinical management strategies, such as laboratory This calls diagnostic approaches combine high sensitivity and specificity, while also being suitable point-of-care testing (POCT) in remote locations minimal staff training low costs. Content In this paper, we outline limitations existing confirmatory methods, ELISA RT-PCR, which are time-consuming, expensive, require skilled personnel. We highlight alternative strategies overcome these challenges. Additionally, paper emphasizes growing demand diagnosing reduce risk death, must addressed next-generation approaches. Summary propose adoption fluorescence immunoassay (FIA) chemiluminescence (CLIA), have potential methods. Outlook Improvements diagnosis, specific focus on identifying POCT setting, help achieve goal deaths dengue.

Language: Английский

Citations

0
Fluorescence-Enabled Portable Droplet Microfluidic Paper-based Analytical Device for Rapid and Sensitive Biotoxicity Assay DOI
Demian I. Njoku, Wanqing Dai, Jiayu Chen

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116784 - 116784

Published: April 1, 2025

Language: Английский

Citations

0
Development of a high-performance sliding microneedle-lateral flow immunoassay strip device for ultra-rapid point-of-care diagnosis DOI
Soo-bin Yu, Jae Hwan Jung

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The HP-SML device was developed by extending and angling microneedles to enhance ISF extraction speed, enabling user-friendly diagnosis using only a minimal volume of interstitial fluid.

Language: Английский

Citations

0
Black palladium nanoparticle-based lateral flow immunoassay for cardiovascular disease diagnosis DOI Creative Commons
Hong Ding, Yao Nie, Zhen Chen

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(20), P. 15490 - 15496

Published: Jan. 1, 2025

The PdNP-based LFIA for the detection of Lp-PLA2 address sensitivity limitations colorimetric LFIA, due to excellent visual discriminability and target recognition ability.

Language: Английский

Citations

0