Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(12)
Published: Nov. 29, 2024
ABSTRACT
MXene‐based
hydrogels
represent
a
significant
advancement
in
biomedical
material
science,
leveraging
the
unique
properties
of
2D
MXenes
and
versatile
functionality
hydrogels.
This
review
discusses
recent
developments
integration
into
hydrogel
matrices,
focusing
on
their
applications
such
as
wound
healing,
drug
delivery,
antimicrobial
activity,
tissue
engineering,
biosensing.
MXenes,
due
to
remarkable
electrical
conductivity,
mechanical
robustness,
tunable
surface
chemistry,
enhance
properties,
responsiveness
environmental
stimuli.
Specifically,
have
shown
great
promise
accelerating
healing
through
photothermal
effects,
delivering
drugs
controlled
manner,
serving
antibacterial
agents.
Their
also
enables
targeted
cancer
therapies,
including
chemodynamic
facilitated
by
high
conductivity
properties.
Despite
promising
progress,
challenges
ensuring
biocompatibility
optimizing
synthesis
for
large‐scale
production
remain.
aims
provide
comprehensive
overview
current
state
applications,
highlighting
ongoing
advancements
potential
future
directions
these
multifunctional
materials.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(38)
Published: Aug. 9, 2024
Dual-mode
readout
platforms
with
colorimetric
and
electrochemiluminescence
(ECL)
signal
enhancement
are
proposed
for
the
ultrasensitive
flexible
detection
of
monkeypox
virus
(MPXV)
in
different
scenes.
A
new
nanotag,
Ru@U6-Ru/Pt
NPs
is
constructed
dual-mode
by
integrating
double-layered
ECL
luminophores
nanozyme
using
Zr-MOF
(UiO-66-NH
Critical Reviews in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 25
Published: Sept. 17, 2024
This
comprehensive
review
delves
into
the
advancements
and
challenges
in
biosensing,
with
a
strong
emphasis
on
transformative
potential
of
CRISPR
technology
for
early
rapid
detection
infectious
diseases.
It
underscores
versatility
CRISPR/Cas
systems,
highlighting
their
ability
to
detect
both
nucleic
acids
non-nucleic
acid
targets,
seamless
integration
isothermal
amplification
techniques.
The
provides
thorough
examination
latest
developments
CRISPR-based
biosensors,
detailing
unique
properties
such
as
high
specificity
programmability,
which
make
them
particularly
effective
detecting
disease-associated
acids.
While
focuses
due
its
critical
role
diagnosing
diseases,
it
also
explores
broader
applications
thereby
acknowledging
technology's
potential.
Additionally,
identifies
existing
challenges,
need
improved
signal
real-world
applicability,
offers
future
perspectives
aimed
at
overcoming
these
hurdles.
ultimate
goal
is
advance
development
highly
sensitive
specific
biosensors
that
can
be
used
widely
improving
human
health,
point-of-care
settings
resource-limited
environments.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(10)
Published: Oct. 1, 2024
ABSTRACT
Nanogels
represent
a
significant
innovation
in
the
fields
of
nanotechnology
and
biomedical
engineering,
combining
properties
hydrogels
nanoparticles
to
create
versatile
platforms
for
drug
delivery,
tissue
bioimaging,
other
applications.
These
nanoscale
hydrogels,
typically
ranging
from
10
1000
nm,
possess
unique
characteristics
such
as
high
water
content,
biocompatibility,
ability
encapsulate
both
hydrophilic
hydrophobic
molecules.
The
review
explores
synthesis,
structural
configurations,
stimuli‐responsive
nature
nanogels,
highlighting
their
adaptability
targeted
including
across
challenging
barriers
like
blood–brain
barrier.
Furthermore,
paper
delves
into
applications
particularly
delivery
systems,
demonstrating
potential
revolutionize
these
fields.
Despite
promising
preclinical
results,
challenges
remain
translating
technologies
clinical
practice,
issues
related
stability,
scalability,
regulatory
approval.
concludes
by
discussing
future
perspectives,
emphasizing
need
further
research
optimize
ultimately
aiming
enhance
efficacy
safety
settings.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
ABSTRACT
Contagious
diseases
caused
by
different
types
of
highly
contagious
pathogens,
such
as
SARS‐CoV‐2,
monkeypox
virus,
Mycobacterium
tuberculosis
,
and
human
immunodeficiency
could
trigger
global
outbreaks
bring
a
huge
public
health
burden.
Advanced
diagnostic,
therapeutic,
preventive
strategies
are
urgently
needed
to
deal
with
the
epidemic
diseases.
Aggregation‐induced
emission
(AIE)
has
emerged
one
promising
candidates
that
exhibit
tunable
photophysical
properties,
high
biocompatibility,
exceptional
photostability,
distinguishing
aggregation‐enhanced
fluorescence.
As
result,
they
offer
effective
for
diagnosis,
treatment,
prevention
This
review
systematically
outlined
latest
research
progress
AIE‐based
biomaterials
mechanisms
in
The
versatility
AIE
molecules,
well
efficient
fluorescence
potential
innovative
combat
these
challenges.
Thanks
recent
advances
materials
science
better
understanding
aggregation‐induced
luminogens
(AIEgens),
AIEgens
have
great
provide
solutions
detection,
By
reviewing
state‐of‐the‐art
methods
killing,
agents
highlighting
technological
developments,
this
outlook
aims
promote
development
new
means
control
emerging,
re‐emerging,
major
further
activities
critical
area
research.
Small Structures,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
To
effectively
address
crisis
emergence
of
new
virus
such
as
monkeypox,
a
collective
and
collaborative
effort
between
scientists,
engineers,
innovators,
artists
from
all
ages,
regions,
diverse
fields
is
required.
This
review
explores
holistic
approach
to
addressing
the
monkeypox
by
integrating
nanobiosensors,
artificial
intelligence,
visual
arts,
humanities,
social
sciences.
Traditional
diagnostic
methods
are
often
limited
time,
accessibility,
accuracy,
but
advancement
point‐of‐care
smart
nanobiosensors
offers
promising
shift
toward
rapid,
precise,
accessible
diagnostics.
They
enhance
ability
screen,
diagnose,
monitor
infections
efficiently,
contributing
better
disease
management.
Beyond
technological
innovation,
essential
role
sciences
in
fostering
public
engagement,
understanding,
acceptance
tools
emphasized.
Visual
arts
can
illustrate
scientific
concepts,
making
them
more
relatable,
while
storytelling
through
various
media
reduce
stigma
promote
preventive
measures.
Social
provide
insights
into
cultural
attitudes,
behaviors,
health
challenges,
ensuring
that
solutions
integrated
communities.
By
combining
these
disciplines,
this
presents
comprehensive
framework
for
resilient
global
system
aligns
with
One
Health
principles,
emphasizing
interconnectedness
human,
animal,
environmental
health.
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
35(12)
Published: Dec. 1, 2024
ABSTRACT
This
review
aims
to
provide
a
comprehensive
analysis
of
recent
advancements
in
smart
microneedles
(MNs)
within
the
biomedical
field,
focusing
on
integration
stimuli‐responsive
polymers
for
enhanced
therapeutic
and
diagnostic
applications.
Conventional
drug
delivery
methods
are
known
face
limitations
precision,
safety,
patient
compliance,
which
can
be
addressed
by
innovative
features
MNs.
Through
use
various
polymers,
these
MNs
have
been
designed
react
environmental
or
physiological
cues,
allowing
on‐demand
release,
biomarker
sensing,
localized
interventions.
Fundamental
materials
used
fabrication
MNs,
including
metals,
composite
hydrogels,
reviewed,
different
categories
stimuli‐responsiveness,
such
as
photo,
electro,
thermal,
mechanical,
biochemical,
explored.
Application‐specific
designs
areas
delivery,
cancer
therapy,
diabetes
management,
skin
disease
treatments
also
examined.
this
discussion,
it
is
highlighted
that
poised
play
significant
role
advancing
personalized
noninvasive
medical
treatments.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
With
the
increasing
incidence
of
thyroid
cancer
worldwide
and
demand
for
surgery,
risk
parathyroid
injury
is
also
increasing,
which
will
lead
to
postoperative
hypoparathyroidism
(HP)
hypocalcemia.
In
order
improve
quality
life
patients
after
there
an
urgent
need
develop
a
novel
platform
that
can
identify
gland
immediately
during
surgery.
The
promotes
increase
blood
calcium
concentration
by
secreting
hormone
(PTH).
Therefore,
in
this
study,
we
used
sensitive
surface-enhanced
Raman
spectroscopy
(SERS)
technique
rapid
detection
PTH,
while
near-infrared
dye
IR808
was
resonance
with
incident
excitation
wavelength
785
nm
achieve
surface
enhanced
(SERRS)
effect
provide
higher
signal.
signal
up
200-fold
compared
nonresonant
sulfhydryl
molecules.
addition,
aptamer-antibody
mode
low
Gibbs
free
energy
(ΔG)
dissociation
constant
(Kd),
using
sandwich
method,
specific
recognition
PTH.
By
optimizing
incubation
temperature,
aptamer
dosage,
particle
concentration,
other
key
factors,
optimal
conditions
system
were
obtained.
sensitivity
PTH
as
high
9.75
pg/mL
at
5
min
time.
work,
achieved
extension
from
standard
products
rats
clinically
practical
samples.
Finally,
eluate
samples
obtained
actual
clinical
operations
lateral
flow
biosensor
(LFB),
chemiluminescence
microparticle
immunoassay
(CMIA),
SERRS,
respectively.
CMIA
results
reference
standard,
SERRS
assay
94%
specificity
100%.
This
study
provides
new
ideas
methods
refined
development
improving
safety
patients,
promoting
intraoperative
diagnosis
treatment.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(2)
Published: Feb. 1, 2025
ABSTRACT
Recent
developments
in
polymer
materials
have
led
to
an
increased
implementation
of
hydrogels
biomedical
settings,
especially
the
creation
smart
hydrogels.
Traditional
single‐network
often
exhibit
challenges,
such
as
poor
mechanical
strength,
insufficient
biocompatibility,
and
slow
response
rates.
To
address
these
issues,
researchers
introduced
Interpenetrating
Polymer
Network
(IPN)
hydrogels,
which
significantly
improve
strength
via
topological
entanglements
physical
interactions.
This
dual‐network
design
not
only
enhances
biocompatibility
but
also
responsiveness
stimuli,
endowing
with
distinctive
properties
like
cell
adhesion,
conductivity,
hemostatic
functions,
antioxidant
abilities,
color‐changing
properties.
The
purpose
this
article
is
elucidate
factors
that
trigger
stimuli
IPN
their
impacts
on
cellular
behavior,
various
applications
they
can
serve.
A
comprehensive
overview
provided
regarding
classification,
mechanisms,
performance
attributes,
related
subjects.
Ultimately,
review
emphasizes
promise
hold
fulfilling
increasing
need
for
innovative
improved
features
sector.
