Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

Advances in total antioxidant capacity detection based on nanozyme

Talanta, Journal Year: 2025, Volume and Issue: 292, P. 127941 - 127941

Published: March 13, 2025

Language: Английский

Deciphering of laccase-like activity ruthenium single-atom nanozyme for identification/quantification and remediation of phenolic pollutants

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 426, P. 137112 - 137112

Published: Dec. 10, 2024

Language: Английский