The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Nature Medicine, Journal Year: 2015, Volume and Issue: 21(3), P. 263 - 269

Published: Feb. 16, 2015

Language: Английский

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Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(2), P. 262 - 284

Published: Feb. 1, 2017

Language: Английский

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Acetyl Coenzyme A: A Central Metabolite and Second Messenger

Cell Metabolism, Journal Year: 2015, Volume and Issue: 21(6), P. 805 - 821

Published: June 1, 2015

Language: Английский

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NLRP3 inflammasome and its inhibitors: a review

Frontiers in Pharmacology, Journal Year: 2015, Volume and Issue: 6

Published: Nov. 5, 2015

Inflammasomes are newly recognized, vital players in innate immunity. The best characterized is the NLRP3 inflammasome, so-called because protein complex belongs to family of nucleotide-binding and oligomerization domain-like receptors (NLRs) also known as "pyrin domain-containing 3". inflammasome associated with onset progression various diseases, including metabolic disorders, multiple sclerosis, inflammatory bowel disease, cryopyrin-associated periodic fever syndrome (CAPS), well other auto-immune auto-inflammatory diseases. Several inhibitors have been described, some which show promise clinic. present review will describe structure mechanisms activation its association state research into inhibitors.

Language: Английский

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β-Hydroxybutyrate: A Signaling Metabolite

Annual Review of Nutrition, Journal Year: 2017, Volume and Issue: 37(1), P. 51 - 76

Published: Aug. 21, 2017

Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone β-hydroxybutyrate (BHB) is synthesized liver from fatty acids represents an essential carrier of energy to peripheral tissues when supply glucose too low for body's energetic needs, such as during periods prolonged exercise, starvation, or absence carbohydrates. In addition its activity metabolite, BHB increasingly understood have cellular signaling functions. These functions broadly link outside environment epigenetic gene regulation function, their actions may be relevant a variety human diseases well aging.

Language: Английский

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Meal frequency and timing in health and disease

Proceedings of the National Academy of Sciences, Journal Year: 2014, Volume and Issue: 111(47), P. 16647 - 16653

Published: Nov. 17, 2014

Although major research efforts have focused on how specific components of foodstuffs affect health, relatively little is known about a more fundamental aspect diet, the frequency and circadian timing meals, potential benefits intermittent periods with no or very low energy intakes. The most common eating pattern in modern societies, three meals plus snacks every day, abnormal from an evolutionary perspective. Emerging findings studies animal models human subjects suggest that restriction as 16 h can improve health indicators counteract disease processes. mechanisms involve metabolic shift to fat metabolism ketone production, stimulation adaptive cellular stress responses prevent repair molecular damage. As data optimal crystalizes, it will be critical develop strategies incorporate those patterns into care policy practice, lifestyles population.

Language: Английский

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Intermittent metabolic switching, neuroplasticity and brain health

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(2), P. 81 - 94

Published: Jan. 11, 2018

Language: Английский

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Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

Cell Metabolism, Journal Year: 2016, Volume and Issue: 24(2), P. 256 - 268

Published: July 28, 2016

Language: Английский

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An energetic view of stress: Focus on mitochondria

Frontiers in Neuroendocrinology, Journal Year: 2018, Volume and Issue: 49, P. 72 - 85

Published: Jan. 12, 2018

Energy is required to sustain life and enable stress adaptation. At the cellular level, energy largely derived from mitochondria – unique multifunctional organelles with their own genome. Four main elements connect stress: (1) at molecular, (epi)genetic, cellular, organellar, systemic levels components of responses; (2) Glucocorticoids other steroid hormones are produced metabolized by mitochondria; (3) Reciprocally, respond neuroendocrine metabolic mediators; (4) Experimentally manipulating mitochondrial functions alters physiological behavioral responses psychological stress. Thus, endocrine that provide both signals direct Neural circuits regulating social behavior as well psychopathological processes also influenced energetics. An integrative view an energy-driven process opens new opportunities study mechanisms adaptation regulation across lifespan.

Language: Английский

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Cell Metabolism, Journal Year: 2017, Volume and Issue: 26(3), P. 539 - 546.e5

Published: Sept. 1, 2017

Language: Английский

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