Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(25)
Published: April 26, 2024
Adaptive
metabolic
responses
and
innate
metabolites
hold
promising
therapeutic
potential
for
stroke,
while
targeted
interventions
require
a
thorough
understanding
of
underlying
mechanisms.
Adiposity
is
noted
modifiable
risk
factor
recent
research
suggests
that
it
benefits
neurological
rehabilitation.
During
the
early
phase
experimental
lipidomic
results
showed
fat
depots
underwent
pronounced
lipolysis
released
fatty
acids
(FAs)
feed
into
consequent
hepatic
FA
oxidation
ketogenesis.
Systemic
supplementation
with
predominant
ketone
beta-hydroxybutyrate
(BHB)
found
to
exert
discernible
effects
on
preserving
blood-brain
barrier
(BBB)
integrity
facilitating
neuroinflammation
resolution.
Meanwhile,
blocking
FAO-ketogenesis
processes
by
administration
CPT1α
antagonist
or
shRNA
targeting
HMGCS2
exacerbated
endothelial
damage
aggravated
stroke
severity,
whereas
BHB
blunted
these
injuries.
Mechanistically,
unveiled
infusion
taken
up
monocarboxylic
acid
transporter
1
(MCT1)
specifically
expressed
in
cerebral
endothelium
upregulated
expression
tight
junction
protein
ZO-1
enhancing
local
β-hydroxybutyrylation
H3K9
at
promoter
TJP1
gene.
Conclusively,
an
adaptive
mechanism
elucidated
which
acute
stimulates
restore
BBB
after
stroke.
Ketogenesis
functions
as
responder
restrain
progression,
providing
novel
prospectives
clinical
translation.
New England Journal of Medicine,
Journal Year:
2019,
Volume and Issue:
381(26), P. 2541 - 2551
Published: Dec. 25, 2019
Evidence
is
accumulating
that
eating
in
a
6-hour
period
and
fasting
for
18
hours
can
trigger
metabolic
switch
from
glucose-based
to
ketone-based
energy,
with
increased
stress
resistance,
longevity,
decreased
incidence
of
diseases,
including
cancer
obesity.
Protein & Cell,
Journal Year:
2021,
Volume and Issue:
13(12), P. 877 - 919
Published: May 29, 2021
Abstract
Metabolic
rewiring
and
epigenetic
remodeling,
which
are
closely
linked
reciprocally
regulate
each
other,
among
the
well-known
cancer
hallmarks.
Recent
evidence
suggests
that
many
metabolites
serve
as
substrates
or
cofactors
of
chromatin-modifying
enzymes
a
consequence
translocation
spatial
regionalization
metabolites.
Various
metabolic
alterations
modifications
also
reportedly
drive
immune
escape
impede
immunosurveillance
within
certain
contexts,
playing
important
roles
in
tumor
progression.
In
this
review,
we
focus
on
how
reprogramming
cells
reshapes
alterations,
particular
acetylation
methylation
histone
proteins
DNA.
We
discuss
other
eminent
such
as,
succinylation,
hydroxybutyrylation,
lactylation,
update
current
advances
metabolism-
modification-based
therapeutic
prospects
cancer.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(6), P. 2061 - 2061
Published: March 17, 2020
Peroxisome
proliferator-activated
receptor
(PPAR)
α,
β/δ,
and
γ
modulate
lipid
homeostasis.
PPARα
regulates
metabolism
in
the
liver,
organ
that
largely
controls
whole-body
nutrient/energy
homeostasis,
its
abnormalities
may
lead
to
hepatic
steatosis,
steatohepatitis,
steatofibrosis,
liver
cancer.
PPARβ/δ
promotes
fatty
acid
β-oxidation
extrahepatic
organs,
PPARγ
stores
triacylglycerol
adipocytes.
Investigations
using
liver-specific
PPAR-disrupted
mice
have
revealed
major
but
distinct
contributions
of
three
PPARs
liver.
This
review
summarizes
findings
PPAR-null
discusses
role
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(22), P. 8767 - 8767
Published: Nov. 20, 2020
Under
normal
physiological
conditions
the
brain
primarily
utilizes
glucose
for
ATP
generation.
However,
in
situations
where
is
sparse,
e.g.,
during
prolonged
fasting,
ketone
bodies
become
an
important
energy
source
brain.
The
brain’s
utilization
of
ketones
seems
to
depend
mainly
on
concentration
blood,
thus
many
dietary
approaches
such
as
ketogenic
diets,
ingestion
medium-chain
fatty
acids
or
exogenous
ketones,
facilitate
significant
changes
metabolism.
Therefore,
these
may
ameliorate
crisis
neurodegenerative
diseases,
which
are
characterized
by
a
deterioration
metabolism,
providing
therapeutic
advantage
diseases.
Most
clinical
studies
examining
neuroprotective
role
have
been
conducted
patients
with
Alzheimer’s
disease,
imaging
support
notion
enhancing
metabolism
ketones.
Likewise,
few
show
modest
functional
improvements
Parkinson’s
disease
and
cognitive
benefits
with—or
at
risk
of—Alzheimer’s
after
interventions.
Here,
we
summarize
current
knowledge
how
interventions
discuss
emphasizing
data.
Science,
Journal Year:
2018,
Volume and Issue:
362(6416), P. 764 - 770
Published: Nov. 15, 2018
For
decades,
dietary
advice
was
based
on
the
premise
that
high
intakes
of
fat
cause
obesity,
diabetes,
heart
disease,
and
possibly
cancer.
Recently,
evidence
for
adverse
metabolic
effects
processed
carbohydrate
has
led
to
a
resurgence
in
interest
lower-carbohydrate
ketogenic
diets
with
content.
However,
some
argue
relative
quantity
little
relevance
health
focus
should
instead
be
placed
which
particular
or
sources
are
consumed.
This
review,
by
nutrition
scientists
widely
varying
perspectives,
summarizes
existing
identify
areas
broad
consensus
amid
ongoing
controversy
regarding
macronutrients
chronic
disease.
Frontiers in Neurology,
Journal Year:
2018,
Volume and Issue:
9
Published: Aug. 24, 2018
Skeletal
muscle
is
an
essential
regulator
of
energy
homeostasis
and
a
potent
coordinator
exercise-induced
adaptations
in
other
organs
including
the
liver,
fat
or
brain.
muscle-initiated
crosstalk
with
tissues
accomplished
though
secretion
myokines,
protein
hormones
which
can
exert
autocrine,
paracrine
long-distance
endocrine
effects.
In
addition,
enhanced
release
uptake
metabolites
from
into
contracting
cells,
respectively,
likewise
act
as
powerful
mediator
tissue
interactions,
particular
regard
to
central
nervous
system.
The
present
review
will
discuss
current
stage
knowledge
regarding
how
exercise
secretome
improve
broad
range
brain
functions
related
vascularization,
neuroplasticity,
memory,
sleep
mood.
Even
molecular
cellular
mechanisms
underlying
communication
between
still
poorly
understood,
physical
activity
represents
one
most
effective
strategies
reduce
prevalence
incidence
depression,
cognitive,
metabolic
degenerative
neuronal
disorders,
thus
warrants
further
study.
