Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 76(13), P. 2547 - 2557
Published: April 9, 2019
Language: Английский
Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 76(13), P. 2547 - 2557
Published: April 9, 2019
Language: Английский
Journal of Clinical Medicine, Journal Year: 2019, Volume and Issue: 8(9), P. 1385 - 1385
Published: Sept. 4, 2019
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress thought to be primary cause. Considering that mitochondria are the main source of ROS, we have set out provide general overview on how generated related T2D. Enhanced generation reactive oxygen species (ROS) occurs as consequence an overload glucose phosphorylation. Endoplasmic reticulum (ER) plays important role stress, it also ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAMs) means ROS promote ER stress. Therefore, state mitochondrial dysfunction consequences this vicious cycle. implication release exposure pancreatic β-cells make them especially susceptible dysfunction. In fact, crosstalk mechanisms with alterations homeostasis can lead diabetes-associated insulin-resistance status. present review, discuss current knowledge relationship mitochondria, inflammation, lipotoxicity
Language: Английский
Citations
471Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 174 - 174
Published: Jan. 26, 2021
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory chronic liver diseases, including non-alcoholic disease (NAFLD). Chronic impairment lipid metabolism closely related to alterations oxidant/antioxidant balance, which affect metabolism-related organelles, leading cellular lipotoxicity, peroxidation, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. Increased OxS also triggers hepatocytes pathways, inflammation fibrogenesis, contributing progression steatohepatitis (NASH). The antioxidant response, regulated by Nrf2/ARE pathway, key component this process counteracts oxidative stress-induced damage, restoration normal metabolism. Therefore, modulation response emerges as an interesting target prevent NAFLD development progression. This review highlights link between disturbed context NAFLD. In addition, emerging potential therapies based on effects their likely molecular targets are discussed.
Language: Английский
Citations
363Frontiers in Endocrinology, Journal Year: 2018, Volume and Issue: 9
Published: July 16, 2018
Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell function. Optimal function mass essential for glucose homeostasis impairment leads to the development of diabetes. Elevated levels circulating fatty acids (FAs) disturbances lipid metabolism regulation are associated with obesity, they major factors influencing increase incidence type Chronic free FA (FFA) treatment induces dysfunction; therefore, reduction elevated plasma FFA might be an important therapeutic target obesity Lipid signals via receptors, intracellular mechanisms involved FFA-induced apoptosis. In this paper, we discuss actions beta cells, including effects on metabolic pathways stress responses, help further understand molecular lipotoxicity-induced
Language: Английский
Citations
274Essays in Biochemistry, Journal Year: 2020, Volume and Issue: 64(4), P. 607 - 647
Published: Aug. 24, 2020
Abstract Metabolism consists of a series reactions that occur within cells living organisms to sustain life. The process metabolism involves many interconnected cellular pathways ultimately provide with the energy required carry out their function. importance and evolutionary advantage these can be seen as remain unchanged by animals, plants, fungi, bacteria. In eukaryotes, metabolic cytosol mitochondria utilisation glucose or fatty acids providing majority in animals. is organised into distinct either maximise capture minimise its use. split chemical comprise both synthesis degradation complex macromolecules known anabolism catabolism, respectively. basic principles consumption production are discussed, alongside biochemical make up fundamental processes for
Language: Английский
Citations
267Journal of Lipid Research, Journal Year: 2019, Volume and Issue: 60(10), P. 1648 - 1697
Published: June 18, 2019
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a widespread recognition adipose tissue as an endocrine organ. Many tissue-secreted signaling mediators (adipokines) have been identified since then, much has learned about how communicates with other organs the body maintain systemic homeostasis. Beyond proteins, additional factors, such lipids, metabolites, noncoding RNAs, extracellular vesicles (EVs), released by participate in this process. Here, we review diverse mechanisms utilizes relay information organs. We discuss recently adipokines (proteins, metabolites) briefly outline contributions RNAs EVs ever-increasing complexities inter-organ communication. conclude reflecting on central aspects adipokine biology, namely, contribution distinct depots cell types secretion, phenomenon resistance, capacity act both source sink mediators.
Language: Английский
Citations
263Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(11), P. 1675 - 1699
Published: Oct. 18, 2022
Language: Английский
Citations
258Nutrients, Journal Year: 2019, Volume and Issue: 11(9), P. 2022 - 2022
Published: Aug. 28, 2019
Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the FFA profile subjects T2DM changes unclear, but it thought that dietary fats to lipid metabolism are likely contribute. Therefore, establishing in specific FFAs individual’s important. Each type has different effects on physiological processes, including regulation lipolysis lipogenesis adipose tissue, inflammation, endocrine signalling composition properties cellular membranes. Alterations such processes due altered concentrations/profiles can potentially result development insulin resistance coagulatory defects. Finally, fibrates statins, lipid-regulating drugs prescribed T2DM, also exert part their beneficial impacting concentrations. Thus, interesting consider concentration plasma. Collectively, we review how explore downstream pathological implications changes.
Language: Английский
Citations
255Cell Death and Disease, Journal Year: 2020, Volume and Issue: 11(10)
Published: Oct. 24, 2020
Abstract Obesity has been recognized as a major risk factor for chronic kidney disease, but the underlying mechanism remains elusive. Here, we investigated whereby long-term high-fat diet (HFD) feeding induces renal injury in mice. The C57BL/6 mice fed HFD 16 weeks developed obesity, diabetes, and dysfunction manifested by albuminuria blood accumulation of BUN creatinine. HFD-fed showed marked glomerular tubular injuries, including prominent defects filtration barrier increased cell apoptosis. Mechanistically, markedly triglyceride cholesterol contents activated lipogenic pathways synthesis. also oxidative stress induced mitochondrial fission cells, thereby activating pro-apoptotic pathway. In HK-2 mesangial cultures, high glucose, fatty acid, TNF-α combination was able to activate pathways, increase stress, promote fission, pathway, all which could be attenuated an inhibitor that depleted reactive oxygen species. Taken together, these observations suggest causes at least part result tissue lipid accumulation, dysfunction, excess programmed death.
Language: Английский
Citations
212Metabolism, Journal Year: 2022, Volume and Issue: 129, P. 155142 - 155142
Published: Jan. 20, 2022
Language: Английский
Citations
188Biomaterials, Journal Year: 2021, Volume and Issue: 277, P. 121114 - 121114
Published: Sept. 1, 2021
Language: Английский
Citations
180