Suppressive Effects of β-Hydroxybutyrate Administration on Lipopolysaccharide-Induced Inflammation in Broiler Chickens DOI Creative Commons

T Horiuchi,

Kyohei Furukawa, Motoi Kikusato

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(9), P. 405 - 405

Published: Sept. 2, 2024

Background: This study aimed to evaluate the suppressive effects of β-hydroxybutyrate (BHB) administration on lipopolysaccharide (LPS)-induced inflammation in broiler chickens. Methods: Twenty-day-old male chickens were randomly allocated three groups, each which was treated with saline (control), intraperitoneal LPS [1.5 mg/kg body weight (BW), Escherichia coli O127:B8], or plus BHB (3 mmol/kg BW). Results: Plasma albumin and total protein concentration significantly reduced by administration, while co-treatment partially attenuated effects. The treatment induced plasma aspartate alanine aminotransferase activities, interleukin (IL)-6 concentration, increases suppressed (p < 0.05). increased gene expression levels IL-1β, IL-6, IL-18 spleen peripheral blood monocytes (PBMC), spleen. Relatively higher dehydrogenase 1 succinyl-CoA:3-ketoacid CoA transferase observed skeletal muscle, these lower PBMC liver. Conclusions: present results suggest that can suppress LPS-induced inflammation, ketolytic enzyme may be involved

Language: Английский

Comparative Metagenomic Analysis Reveals Rhizosphere Microbiome Assembly and Functional Adaptation Changes Caused by Clubroot Disease in Chinese Cabbage DOI Creative Commons
Y. Liu,

Lai Jia,

Xiaofang Sun

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1370 - 1370

Published: July 4, 2024

Clubroot is a major disease and severe threat to Chinese cabbage, it caused by the pathogen Plasmodiophora brassicae Woron. This an obligate biotrophic protist can persist in soil form of resting spores for more than 18 years, which easily be transmitted through number agents, resulting significant economic losses global cabbage production. Rhizosphere microbiomes play fundamental roles occurrence development plant diseases. The changes rhizosphere microorganisms could reveal severity diseases provide basis their control. Here, we studied microbiota after clubroot infections with different severities employing metagenomic sequencing, aim exploring relationships between health, microbial communities, environments; then, identified potential biomarker microbes disease. results showed that significantly affected community composition structure soil, functions were also dramatically influenced it. Four had great biocontrol from obtained results; they genera Pseudomonas, Gemmatimonas, Sphingomonas, Nocardioides. Soil pH, organic matter contents, total nitrogen, cation exchange capacity environmental factors modulating microbiome assembly. In addition, information processing was extremely strengthened when subjected invasion, but weakened became serious. particular, oxidative phosphorylation glycerol-1-phosphatase might have critical enhancing cabbage’s resistance work revealed interactions mechanisms among factors, disease, functions, may novel foundation further studies using microbiological or metabolic methods develop disease-resistant cultivation technologies.

Language: Английский

Citations

4
Ketogenesis instigates immune suppression in enzalutamide resistant prostate cancer via OTUD7B β-hydroxybutyrylation DOI
Haoran Jiang, Yuan Zeng,

Weiqiang Ning

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217808 - 217808

Published: May 1, 2025

Language: Английский

Citations

0
Comparative Metagenomic Analysis Reveals Rhizosphere Microbiome Assembly and Functional Adaptation Changes Caused by Clubroot Disease in Chinese Cabbage DOI
Yong Liu,

Lai Jia,

Xiaofang Sun

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

2
Suppressive Effects of β-Hydroxybutyrate Administration on Lipopolysaccharide-Induced Inflammation in Broiler Chickens DOI Open Access

T Horiuchi,

Kyohei Furukawa, Motoi Kikusato

et al.

Published: July 24, 2024

β-hydroxybutyrate (BHB) is generated as one of the ketone bodies in liver under fasted and hypoglycemic conditions. While BHB utilized an alternative energy substrate extrahe-patic tissues/organs, this body has been reported to exert anti-inflammatory effects via modulating inflammatory signaling cascades. Several bacterial pathogens that originated hy-gienic litter conditions consecutively threaten chickens, its harmful constituent, lipopoly-saccharide (LPS), induces intestinal systemic inflammation. Therefore, management inflammation a significant concern poultry production. However, therapeutic on have yet be investigated chickens. This study demonstrated administration can alleviate LPS-induced broiler could dependent gene expression levels ketolytic enzymes, dehydrogenase-1 suc-cinyl-CoA:3-ketoacid CoA transferase, extrahepatic tissues/organs. first show possibly involvement utilization.

Language: Английский

Citations

1
Suppressive Effects of β-Hydroxybutyrate Administration on Lipopolysaccharide-Induced Inflammation in Broiler Chickens DOI Creative Commons

T Horiuchi,

Kyohei Furukawa, Motoi Kikusato

et al.

Veterinary Sciences, Journal Year: 2024, Volume and Issue: 11(9), P. 405 - 405

Published: Sept. 2, 2024

Background: This study aimed to evaluate the suppressive effects of β-hydroxybutyrate (BHB) administration on lipopolysaccharide (LPS)-induced inflammation in broiler chickens. Methods: Twenty-day-old male chickens were randomly allocated three groups, each which was treated with saline (control), intraperitoneal LPS [1.5 mg/kg body weight (BW), Escherichia coli O127:B8], or plus BHB (3 mmol/kg BW). Results: Plasma albumin and total protein concentration significantly reduced by administration, while co-treatment partially attenuated effects. The treatment induced plasma aspartate alanine aminotransferase activities, interleukin (IL)-6 concentration, increases suppressed (p < 0.05). increased gene expression levels IL-1β, IL-6, IL-18 spleen peripheral blood monocytes (PBMC), spleen. Relatively higher dehydrogenase 1 succinyl-CoA:3-ketoacid CoA transferase observed skeletal muscle, these lower PBMC liver. Conclusions: present results suggest that can suppress LPS-induced inflammation, ketolytic enzyme may be involved

Language: Английский

Citations

0