Targeted Theranostic Nanoprobes Assisted In Vivo NIR-II Fluorescence Imaging-Guided Surgery Therapy for Alveolar Echinococcosis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Alveolar echinococcosis (AE) is a serious parasitic infectious disease that highly invasive and destructive to the liver has high mortality rate. However, currently, there no effective targeted imaging treatment method for precise detection therapy of AE. We proposed new two-step targeting strategy (TSTS) AE based on poly(lactic-co-glycolic acid) (PLGA). designed constructed novel type ICG@PLGA@Lips nanoprobe with integrated properties. First, we used characteristics PLGA gluconeogenic raw material target during blood circulation. Then, utilized specifically penetrating shell achieve specific identification in liver. Under 808 nm laser excitation, effectively achieved accurate near-infrared II (NIR-II, 900-1700 nm) fluorescence methods through PDT effects. improved optical properties ICG, while liposomes further biocompatibility nanoprobe. As showed strong NIR-II emission good biocompatibility, advantages navigation surgical resection lesions. Thus, assistance ICG@PLGA@Lips, real-time first time. successfully obtained vivo imaging-guided photodynamic/surgical This TSTS-based exploration provided early AE, which expected significantly improve prognosis patients.

Language: Английский

---

The Inhibitory Effects of NCT503 and Exogenous Serine on High-Selenium Induced Insulin Resistance in Mice

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 311 - 311

Published: Jan. 16, 2025

Objective: This study aims to identify whether the development of insulin resistance (IR) induced by high selenium (Se) is related serine deficiency via inhibition de novo synthesis pathway (SSP) administrations 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (NCT503) or exogenous in mice. Method: forty-eight male C57BL/6J mice were randomly divided into four groups: adequate-Se (0.1 mgSe/kg), high-Se (0.8 +serine (240 mg/kg/day), and +NCT503 (30 mg/kg, twice a week) for 5 months. The glucose tolerance test (GTT) (ITT) used confirm IR with intake, fasting blood levels measured monthly. Se contents plasma tissues detected ICP-MS. (INS), homocysteine (HCY), tested ELISA. Western blot analyses conducted evaluate protein expressions glutathione peroxidase 1 (GPX1), selenoprotein P (SELENOP) PHGDH, PI3K-AKT-mTOR pathway, folate cycle (SHMT1, MTHFR), methionine (MS). Results: An model was developed from group elevated INS levels, impaired tolerance, reduced sensitivity, but not both group. Compared groups, GPX1 SELENOP significantly decreased liver, muscle, pancreas tissues. expression PHGDH higher than that liver (p < 0.05) 0.001). Also, expected effectively inhibited p-AKT (Ser-473) lower pancreas. Conclusions: intake body has been confirmed be partially due deficiency, which led initiation SSP produce endogenous serine. supplementations inhibitors this metabolic could intervention.

Language: Английский

---

Echinacoside alleviates type 2 diabetes mellitus through inhibiting hepatic gluconeogenesis via gut bacterial-fungal trans-kingdom network reconstruction

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156802 - 156802

Published: April 1, 2025

Language: Английский

---

Berberine and health outcomes: an overview of systematic reviews

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 23, 2025

Language: Английский

---

Rutin alleviates advanced glycosylation end products-induced insulin resistance by inhibiting SOCS3/IRS1 and activating PI3K/AKT signaling pathways in HepG2 cells

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 120, P. 106385 - 106385

Published: Aug. 2, 2024

Language: Английский

---

Hesperetin-copper (II) complex improves liver glucose metabolism by regulating the IRS-1/PI3K/AKT signaling pathway in T2DM mice

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105408 - 105408

Published: Nov. 5, 2024

Language: Английский

---

Gluconeogenesis unraveled: A proteomic Odyssey with machine learning

Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

---

The relevance of the heme oxygenase system in alleviating diabetes-related hormonal and metabolic disorders

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1871(1), P. 167552 - 167552

Published: Oct. 25, 2024

Language: Английский

---

ZBED3 exacerbates hyperglycemia by promoting hepatic gluconeogenesis through CREB signaling

Metabolism, Journal Year: 2024, Volume and Issue: unknown, P. 156049 - 156049

Published: Oct. 1, 2024

Language: Английский

---

Evaluation of Hypoglycemic Polyphenolic Compounds in Blueberry Extract: Functional Effects and Mechanisms

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1490 - 1490

Published: Dec. 6, 2024

Blueberries are rich in polyphenols, which exhibit significant anti-diabetic activity. In this study, polyphenolic compounds with potential hypoglycemic activity were identified from blueberry polyphenol extract (BPE). This research focused on assessing the effects of BPE and its (dihydroquercetin gallic acid) diabetic mice induced by streptozotocin (STZ) high-fat diet (HFD), as well related fundamental mechanisms. The findings revealed that treatment effectively reduced levels fasting blood glucose (FBG) decreasing hepatic oxidative stress, regulating lipid metabolism disorders improving insulin resistance. Investigations into signaling pathway can modulate expression Egfr, Insr, Irs-1, Pi3k Akt, thereby influencing metabolism. study provides a foundation for considering polyphenols nutritional dietary supplement prevention intervention diabetes.

Language: Английский

---