Bacteria and fungi of the lung: allies or enemies? DOI Creative Commons

Enrico Garaci,

Marilena Pariano,

Emilia Nunzi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Moving from the earlier periods in which lungs were believed to represent sterile environments, our knowledge on lung microbiota has dramatically increased, first descriptions of microbial communities inhabiting healthy and definition ecological rules that regulate its composition, identification changes occur pathological conditions. Despite limitations as a microbiome reservoir due low biomass abundance, defining composition function upper lower airways may help understanding impact local homeostasis disruption diseases. In particular, metabolic immune significance microbes, their presence or lack thereof, health disease states could be valuable development novel druggable targets treatments. Next-generation sequencing identified intricate inter-microbe association networks comprise true mutualistic antagonistic direct indirect relationships respiratory tract. this review, tripartite interaction bacteria, fungi mammalian host is addressed provide an integrated view microbial-host cross-talk diseases perspective.

Language: Английский

Microbes Saving Lives and Reducing Suffering DOI Creative Commons
Kenneth N. Timmis, Zeynep Ceren Karahan, Juan L. Ramos

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

Citations

3
The role of colonic microbiota amino acid metabolism in gut health regulation DOI Creative Commons
Youli Chen, Jing‐Yuan Fang

Cell Insight, Journal Year: 2025, Volume and Issue: unknown, P. 100227 - 100227

Published: Jan. 1, 2025

The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the large intestine is highly heterogeneous and relevant to health. Despite increasing interest, microbial AA remains relatively unexplored. This review highlights recent advances colonic metabolism, including auxotrophies, synthesis, dissimilatory metabolites, their implications health, focusing on major gastrointestinal diseases colorectal cancer, inflammatory bowel disease, irritable syndrome.

Language: Английский

Citations

0
Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics DOI Creative Commons
Jon-Michael Beasley,

Dorjbal Dorjsuren,

Sankalp Jain

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Antibiotic-resistant bacterial infections loom over humanity as an increasing deadly threat. There exists a dire need for new treatments, especially those that synergize with our existing arsenal of antibiotic drugs to help overcome the gap in efficacy and attenuate development antibiotic-resistance most dangerous pathogens. Quorum sensing systems bacteria drive formation biofilms, increase surface motility, enhance other virulence factors, making these attractive targets discovery novel antibacterials. inhibitors (QSIs) are hypothesized antibiotics, more sensitive effects drugs. In this study, we aimed find synergistic combinations between QSIs known antibiotics combat two deadliest hospital - Pseudomonas aeruginosa Acinetobacter baumannii. We mined biochemical activity databases literature identify known, high against bacteria. used data develop validate Quantitative Structure-Activity Relationship (QSAR) model predicting QSI then employed potential from Inxight database approved investigational tested binary mixtures identified 11 using combinatorial matrix screening approach ten (five each) clinical isolates P. A. baumannii . Amongst explored drug combinations, 31 exhibited effect, including involving naldemedine telotristat, predicted by previously undescribed activity. Although no mixture inhibiting all strains was found, piperacillin combined curcumin, ketoprofen, indomethacin, piroxicam demonstrated broadest antimicrobial action. anticipate further preclinical investigation repurposed may lead candidates.

Language: Английский

Citations

0
Gut Microbes: Therapeutic Target for Neuropsychiatric Disorders DOI
Keya Mallick, Gopal Khodve,

Ritika Ruwatia

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38

Published: Feb. 21, 2025

Language: Английский

Citations

0
Synbiotics of encapsulated Limosilactobacillus fermentum K73 promotes in vitro favorable gut microbiota shifts and enhances short-chain fatty acid production in fecal samples of children with autism spectrum disorder DOI Creative Commons
Katherine Bauer Estrada, Natalia Conde-Martínez, Alejandro Acosta‐González

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116227 - 116227

Published: March 1, 2025

Modulation of the gut microbiota has emerged as a promising approach for addressing gastrointestinal and neurodevelopmental symptoms associated with autism spectrum disorder (ASD). Consequently, this study aimed to evaluate impact four formulated synbiotics comprising Limoscilactobacillus fermentum K73, high-oleic palm oil whey, on composition Colombian children without ASD. These components were encapsulated through high-shear emulsification spray drying. The their individual subjected in vitro digestion fermentation using samples microbiota. Short-chain fatty acids (SCFAs), including lactic, acetic, propionic, butyric acids, quantified HPLC-DAD, while serotonin was determined by an ELISA kit after fermentations. Changes microbial structure assessed sequencing 16S rRNA gene via next-generation (NGS). results revealed decrease abundance genera like Bacteroides Dorea ASD-associated treatment synbiotics. Conversely, increase relative probiotic-related genera, Lactobacillus, Streptococcus, Anaerostipes, observed. Furthermore, analysis SCFAs indicated that synbiotic intervention resulted elevated acid synthesis, alongside propionic acid, which is changes considered beneficial context This evidence suggests L. K73 could represent live biotherapeutic strategy modulating

Language: Английский

Citations

0
Microbiome Shifts and Their Impact on Gut Physiology in Irritable Bowel Syndrome DOI Open Access
Ιωάννα Αγγελετοπούλου, Christos Triantos

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12395 - 12395

Published: Nov. 19, 2024

Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders characterized by recurrent abdominal pain and altered habits. The exact pathophysiological mechanisms for IBS development are not completely understood. Several factors, including genetic predisposition, environmental psychological influences, low-grade inflammation, alterations in motility, dietary habits, have been implicated pathophysiology disorder. Additionally, emerging evidence highlights role gut microbiota IBS. This review aims to thoroughly investigate how impact physiological functions such as brain-gut axis, immune system activation, mucosal permeability, intestinal motility. Our research focuses on dynamic "microbiome shifts", emphasizing enrichment or depletion specific bacterial taxa their profound disease progression pathology. data indicated that populations IBS, reductions beneficial species

Language: Английский

Citations

2
Exploring tryptophan metabolism in cardiometabolic diseases DOI

Nirmala Mouttoulingam,

Soraya Taleb

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Bacteria and fungi of the lung: allies or enemies? DOI Creative Commons

Enrico Garaci,

Marilena Pariano,

Emilia Nunzi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 8, 2024

Moving from the earlier periods in which lungs were believed to represent sterile environments, our knowledge on lung microbiota has dramatically increased, first descriptions of microbial communities inhabiting healthy and definition ecological rules that regulate its composition, identification changes occur pathological conditions. Despite limitations as a microbiome reservoir due low biomass abundance, defining composition function upper lower airways may help understanding impact local homeostasis disruption diseases. In particular, metabolic immune significance microbes, their presence or lack thereof, health disease states could be valuable development novel druggable targets treatments. Next-generation sequencing identified intricate inter-microbe association networks comprise true mutualistic antagonistic direct indirect relationships respiratory tract. this review, tripartite interaction bacteria, fungi mammalian host is addressed provide an integrated view microbial-host cross-talk diseases perspective.

Language: Английский

Citations

0