Peran GnRH agonis DOI Open Access

Erna Suparman,

Eddy Suparman

Jurnal Biomedik JBM, Journal Year: 2016, Volume and Issue: 8(1)

Published: May 16, 2016

Abstract: Gonadotropin Releasing Hormone (GnRH) agonists have a higher biological potential than endogenous GnRH. Administration of GnRH agonist triggers FSH and LH secretion from the pituitary (flare-up effect), however, after several days sensitivity continues to decrease which causes decreases LH, FSH, estrogen, progesterone (down-regulation). Preoperative administration is recommended in uterine fibroid with severe anemia reduce blood loss before, during, surgery. Due shrinking fibroid, laparoscopy or laparotomy Pfannenstiel incision can be performed. Moreover, myomectomy will not require extensive incision, damaged myometrium adhesion are minimum, therefore, those conditions increase success fertility; facilitate removal submucosal histeroscopy; enable vaginal hysterectomy more easily. In patients polycystic ovarial syndrome, suppress high levels testosterone. halt growth size an endometriosis, they used precocious puberty premenstrual syndrome. The combination exogenous gonadotropin plus vitro fertilization associated increased pregnancy rate as compared use gonadotropins without agonist. trigger hypoestrogen that osteoporosis other complaints such hot flushes, dryness, headache, sleep disturbance. combined low-dose estrogen progestin (add-back therapy) these side effects. Addback provision therapy started 12 weeks agonists.Keywords: agonist, gonadotropinAbstrak: (Gonadotropin Hormone) agonis memiliki potensi biologis yang lebih tinggi daripada endogen. Permulaan pemberian memicu pengeluaran dan dari hipofisis effect). Setelah beberapa hari sensitivitas terhadap rangsangan terus berkurang menyebabkan penurunan progesteron (down regulation). Pemberian preoperatif dianjurkan pada mioma uteri dengan berat untuk mengurangi kehilangan darah sebelum, selama setelah operasi. Dengan mengecilnya maka dapat dilakukan tindakan laparoskopi atau laparatomi insisi Pfannenstiel, juga saat miomektomi tidak diperlukan luas, kerusakan miometrium perlekatan menjadi minimal sehingga akan meningkatkan keberhasilan fertilitas; mempermudah pengangkatan submukosum histeroskopi; melakukan histerektomi. pasien sindroma ovarium polikistik menekan tingginya kadar produksi testosteron. menghentikan pertumbuhan ukuran selain itu digunakan pubertas prekok premenstrual. Pada fertilisasi penggunaan kombinasi eksogen ditambah berhubungan peningkatan kehamilan dibandingkan tanpa agonis. keadaan hipoestrogen keluhan lain seperti vagina kering, sakit kepala, gangguan tidur. dikombinasi dosis rendah efek samping tersebut. addback ini dimulai minggu agonis.Kata kunci: agonis,

Language: Английский

Gonadotropin-releasing hormone and its receptor in normal and malignant cells DOI Open Access

Gail S. Harrison,

Margaret E. Wierman, Terry M. Nett

et al.

Endocrine Related Cancer, Journal Year: 2004, Volume and Issue: 11(4), P. 725 - 748

Published: Dec. 1, 2004

Gonadotropin-releasing hormone (GnRH) is the hypothalamic factor that mediates reproductive competence. Intermittent GnRH secretion from hypothalamus acts upon its receptor in anterior pituitary to regulate production and release of gonadotropins, LH FSH. FSH then stimulate sex steroid synthesis gametogenesis gonads ensure The requires pulsatile stimulation by synthesize gonadotropins Clinically, native used a pump delivery system create an episodic pattern restore hormonal defects patients with hypogonadotropic hypogonadism. Agonists are delivered continuous mode turn off function inhibiting gonadotropin production, thus lowering resulting medical castration. They have been endocrine disorders such as precocious puberty, endometriosis leiomyomata, but also studied extensively hormone-dependent malignancies. detection other tissues, including breast, ovary, endometrium, placenta prostate suggested agonists antagonists may direct actions at peripheral targets. This paper reviews current data concerning differential control expression signaling hypothalamic–pituitary axis extrapituitary tissues. Using these backdrop, we review literature about action cancer cells, utility analogs various malignancies update research novel therapies targeted cells promote anti-proliferative effects tumor burden.

Language: Английский

Citations

166
Peran GnRH agonis DOI Open Access

Erna Suparman,

Eddy Suparman

Jurnal Biomedik JBM, Journal Year: 2016, Volume and Issue: 8(1)

Published: May 16, 2016

Abstract: Gonadotropin Releasing Hormone (GnRH) agonists have a higher biological potential than endogenous GnRH. Administration of GnRH agonist triggers FSH and LH secretion from the pituitary (flare-up effect), however, after several days sensitivity continues to decrease which causes decreases LH, FSH, estrogen, progesterone (down-regulation). Preoperative administration is recommended in uterine fibroid with severe anemia reduce blood loss before, during, surgery. Due shrinking fibroid, laparoscopy or laparotomy Pfannenstiel incision can be performed. Moreover, myomectomy will not require extensive incision, damaged myometrium adhesion are minimum, therefore, those conditions increase success fertility; facilitate removal submucosal histeroscopy; enable vaginal hysterectomy more easily. In patients polycystic ovarial syndrome, suppress high levels testosterone. halt growth size an endometriosis, they used precocious puberty premenstrual syndrome. The combination exogenous gonadotropin plus vitro fertilization associated increased pregnancy rate as compared use gonadotropins without agonist. trigger hypoestrogen that osteoporosis other complaints such hot flushes, dryness, headache, sleep disturbance. combined low-dose estrogen progestin (add-back therapy) these side effects. Addback provision therapy started 12 weeks agonists.Keywords: agonist, gonadotropinAbstrak: (Gonadotropin Hormone) agonis memiliki potensi biologis yang lebih tinggi daripada endogen. Permulaan pemberian memicu pengeluaran dan dari hipofisis effect). Setelah beberapa hari sensitivitas terhadap rangsangan terus berkurang menyebabkan penurunan progesteron (down regulation). Pemberian preoperatif dianjurkan pada mioma uteri dengan berat untuk mengurangi kehilangan darah sebelum, selama setelah operasi. Dengan mengecilnya maka dapat dilakukan tindakan laparoskopi atau laparatomi insisi Pfannenstiel, juga saat miomektomi tidak diperlukan luas, kerusakan miometrium perlekatan menjadi minimal sehingga akan meningkatkan keberhasilan fertilitas; mempermudah pengangkatan submukosum histeroskopi; melakukan histerektomi. pasien sindroma ovarium polikistik menekan tingginya kadar produksi testosteron. menghentikan pertumbuhan ukuran selain itu digunakan pubertas prekok premenstrual. Pada fertilisasi penggunaan kombinasi eksogen ditambah berhubungan peningkatan kehamilan dibandingkan tanpa agonis. keadaan hipoestrogen keluhan lain seperti vagina kering, sakit kepala, gangguan tidur. dikombinasi dosis rendah efek samping tersebut. addback ini dimulai minggu agonis.Kata kunci: agonis,

Language: Английский

Citations

1