One-pot, three-component synthesis of pyrrolo[2,3-d]pyrimidine derivatives

Journal of the Mexican Chemical Society, Journal Year: 2018, Volume and Issue: 62(1)

Published: May 21, 2018

A green approach for the synthesis of polyfunctionalized pyrrolo[2,3-d]pyrimidine derivatives was successfully achieved by a one-pot, three-component reaction arylglyoxals, 6-amino-1,3-dimethyluracil and barbituric acid in presence tetra-n-butylammonium bromide (TBAB) (5 mol%) as catalyst ethanol at 50 °C. This protocol has many advantages such high yields (73-95%), simple procedure, short times, easy work-up, mild conditions general applicability.

Language: Английский

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A simple protocol for the green synthesis of a new series of pyrimido[4,5-b][1,6]naphthyridines in the presence of silver nanoparticles (AgNPs)

ARKIVOC, Journal Year: 2018, Volume and Issue: 2019(5), P. 1 - 9

Published: Oct. 16, 2018

Eight polyfunctionalized pyrimidonaphthyridine derivatives has been synthesized, in 79-92% yields, via the one-pot, three-component reaction of aryl glyoxal monohydrates, 6-aminouracil and 4-hydroxyquinolin-2(1H)one H 2 O/EtOH presence AgNPs under mild conditions.In this work colloidal acts as an efficient, economical, green nanocatalyst, leading to a simple method preparation.

Language: Английский

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An efficient synthesis of imidazo[2,1-b][1,3,4]thiadiazol-7-ium hydroxides by a one-pot, three-component reaction in water

Heterocyclic Communications, Journal Year: 2018, Volume and Issue: 24(6), P. 297 - 302

Published: Nov. 17, 2018

Abstract An improved synthesis of 2-ethyl-5-(2-hydroxy-4-oxoquinolin-3(4 H )-ylidene)-6-aryl-5,6-dihydroimidazo[2,1- b ][1,3,4]thiadiazol-7-ium hydroxide derivatives 4a–k via the reaction aryl glyoxal monohydrates 1a–k , quinoline-2,4-diol 2 and 2-amino-[1,3,4]thiadiazole (3) in presence Et 3 N/sulfamic acid O is described. This green protocol characterized by use readily available catalyst reactants, short times, operational simplicity high yields products. The structures all compounds were 1 NMR, 13 C NMR Fourier-transform infrared (FT-IR) spectral data microanalyses.

Language: Английский

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Synthesis of a new series of benzo[d]imidazo[2,1-b]thiazole-1-ium hydroxides by a one-pot, three-component reaction in water

Monatshefte für Chemie - Chemical Monthly, Journal Year: 2019, Volume and Issue: 150(2), P. 317 - 325

Published: Jan. 11, 2019

Language: Английский

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A new and facile synthesis of 3-(2-aryl-6-nitro-1H-indol-3-yl)quinoline-2,4(1H,3H)-diones by sodium alginate as biopolymeric catalyst

Research on Chemical Intermediates, Journal Year: 2020, Volume and Issue: 46(6), P. 3025 - 3036

Published: March 20, 2020

Language: Английский

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