Recent developments in the synthesis of polysubstituted pyridinesviamulticomponent reactions using nanocatalysts

New Journal of Chemistry, Journal Year: 2021, Volume and Issue: 45(28), P. 12328 - 12345

Published: Jan. 1, 2021

This review describes the evolution and application of active metal-based heterometallic NPs as efficient heterogeneous catalysts for synthesis pyridine derivatives by multicomponent reactions in last decade (2010–2020).

Language: Английский

---

Silver-catalyzed synthesis of nitrogen heterocycles: recent advancements

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(21), P. 4332 - 4357

Published: Jan. 1, 2023

Silver catalysis offers environmentally friendly and simple protocols to construct N-heterocycles. Inspired by its appeal, herein we have summarized developments in the silver-catalyzed synthesis of N-heterocycles since 2019.

Language: Английский

---

Ultrasonic‐assisted preparation of Co₃O₄ and Eu‐doped Co₃O₄ nanocatalysts and their application for solvent‐free synthesis of 2‐amino‐4H‐benzochromenes under microwave irradiation

Applied Organometallic Chemistry, Journal Year: 2021, Volume and Issue: 35(8)

Published: May 7, 2021

Co 3 O 4 and Eu‐doped nanocatalysts were synthesized through an ultrasonic‐assisted solvothermal method characterized with X‐ray diffraction (XRD), Fourier transform infrared (FT‐IR), energy‐dispersive (EDX), field‐emission scanning electron microscopy (FESEM) methods. Spinel cubic crystalline system for was confirmed XRD, whereas the spherical morphology of changed to nanorods after Eu 3+ doping, which affirmed FESEM micrographs. Catalytic performance nanomaterials examined synthesis 2‐amino‐4 H ‐benzochromenes using aromatic aldehydes, malononitrile, β‐naphthol condensation under solvent‐free conditions microwave irradiation. Mild reaction conditions, short times, simple setup, affordable catalyst, high‐quality products some advantages this procedure. The efficiency nanocatalyst achieved by about 96%.

Language: Английский

---

Facile Green One-Pot Synthesis and Antiproliferative Activity of Some Novel Functionalized 4-(4-Oxo-4H-chromen-3-yl)­pyrano[2,3-c]pyrazoles and 5-(4-Oxo-4H-chromen-3-yl)­pyrano[2,3-d]pyrimidines

Russian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 58(1), P. 106 - 113

Published: Jan. 1, 2022

Language: Английский

---

One‐pot, three‐component synthesis of polyfunctionalized benzo[h]pyrazolo[3,4‐b][1,6]naphthyridine and benzo[g]pyrazolo[3,4‐b]quinoline derivatives in the presence of silver nanoparticles (AgNPs)

Journal of Heterocyclic Chemistry, Journal Year: 2020, Volume and Issue: 57(11), P. 3961 - 3969

Published: July 24, 2020

Abstract An efficient and straightforward protocol for one‐pot, three‐component reaction of aryl glyoxal monohydrates 1a‐h , 5‐amino‐1‐aryl‐3‐methylpyrazoles 2a b 4‐hydroxyquinoline‐2(1 H )‐one ( 3 ) or 2‐hydroxy‐1,4‐naphthoquinone 4 using silver nanoparticles (AgNPs) as a high performance nanocatalyst in 2 O/EtOH at 60°C afforded the corresponding polyfunctionalized benzo[ h ]pyrazolo[3,4‐ ][1,6]naphthyridines 5a‐h g ]quinolines 6a‐i respectively. Excellent catalytic activity, yields, employing green media nanocatalyst, cost‐effective simple procedure are some notable advantages AgNPs noble metal this synthetic strategy. The structures fused heterocycles were confirmed by their Fourier transform infrared, proton nuclear magnetic resonance 1 H‐NMR), 13 C‐NMR spectral data microanalysis.

Language: Английский

---

Synthesis of 4‐Hydroxy‐3‐(2‐arylimidazo[1,2‐a]pyridin‐3‐yl)quinolin‐2(1H)‐ones in the Presence of DABCO as an Efficient Organocatalyst

Journal of Heterocyclic Chemistry, Journal Year: 2019, Volume and Issue: 56(6), P. 1857 - 1865

Published: May 10, 2019

The one‐pot, three‐component, synthesis of a new series 4‐hydroxy‐3‐(2‐arylimidazo[1,2‐ ]pyridin‐3‐yl)quinolin‐2(1 H )‐ones in the presence DABCO as catalyst has been achieved using aryl glyoxal monohydrates, quinoline‐2,4(1 ,3 )‐dione, and 2‐aminopyridine 2 O/EtOH under reflux conditions. cheapness organocatalyst, simple workup, operational simplicity, regioselectivity, high yields are some advantages this protocol.

Language: Английский

---

Recent applications of aminouracil in multicomponent reactions

ARKIVOC, Journal Year: 2021, Volume and Issue: 2021(1), P. 236 - 272

Published: Feb. 14, 2021

6-Aminouracil and its derivatives are versatile heterocyclic compounds frequently employed to synthesize a wide array of fused uracils annulated with other rings which can serve address biological pharmacological targets.Multicomponent reactions (MCRs) important in the synthesis natural products pharmaceuticals by forming molecular frameworks generally high atom-economy single reaction step.This review embraces various modern synthetic strategies, summarizing recent research developments providing 6-aminouracil highlight progress based on MCRs between 2015 2020.

Language: Английский

---

One-Pot Three-Component Synthesis of a Series of 2-Amino-4-(4-oxo-4H-chromen-3-yl)-5-(2,2,2-trifluoroacetyl)-6-(trifluoromethyl)-4H-pyrans and 2-Amino-4-(4-oxo-4H-chromen-3-yl)-5-(thiophene-2-carbonyl)-6-(trifluoromethyl)-4H-pyrans as Promising Anticancer Agents

Russian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 58(4), P. 584 - 591

Published: April 1, 2022

Language: Английский

---

Synthesis of Heterocyclic Compounds through Multicomponent Reactions Using 6-Aminouracil as Starting Reagent

Current Organic Chemistry, Journal Year: 2021, Volume and Issue: 25(9), P. 1070 - 1095

Published: March 3, 2021

The analogs of 6-Amino uracil are essential components due to their biological activities. is used as an important component for the synthesis heterocyclic compounds like pyrrolo-, pyrido-, pyrimidine-pyrimido scaffolds. Herein, application this compound reviewed a precursor in many cores from 2016 2020.

Language: Английский

---

One-Pot and Three-Component Synthesis of Some Novel Functionalized Chromonyl Pyrido[2,3-d]pyrimidines as Anticancer Agents

Heterocycles, Journal Year: 2021, Volume and Issue: 102(5), P. 930 - 930

Published: Jan. 1, 2021

A facile and efficient method for the construction of functionalized chromonyl pyrido [2,3-d]pyrimidines via a one-pot, three-component reaction 6-aminothiouracil 4,6-diaminopyrimidine-2(1H)-thione with 4-oxo-4Hchromene-3-carboxaldehyde in presence different nitrile active methylene compounds distillated water at 70 o C without using catalyst was achieved.The methodology displayed excellent yields simple workup procedure.The targeted were assessed their vitro anticancer activity against mammary gland breast cancer cell line (MCF-7), liver (HepG-2), human colon (HCT-116) by sulphorhodamine B assay (SRB) method, while Doxorubicin, utilized as standard reference drug.Compounds 4b 6a best potent cytotoxic agents towards (HepG-2) compared Doxorubicin drug IC50 values ranging from 1.1 to 1.8 μg/mL.

Language: Английский

---