Halogenation of Alkenes Using Three‐Component Reactions: A Decade of Development DOI

Rongliang Zeng,

Li Zhang, Dayun Huang

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Abstract Alkenes are valuable feedstocks in organic synthesis. One effective method for synthesizing halides with functional groups close proximity involves the direct difunctionalization of alkenes via three‐component reactions. This approach not only reduces number steps involved synthesis process, but also minimizes waste generation and enables formation complex molecules from simple starting materials. In this review, we mainly discuss decade developments (2013‐2023) two categories: (1) halogenation three‐membered ring intermediates, involving haliranium, thiiranium,seleniranium, aziridinium epoxide species; (2) a radical pathway. Reactions I 2 , BiI 3 NaI, Bu 4 N + [I(O CAr) ] − NIS, NBS, NCS, DBH, BsNMeBr, HBr, HCl, KI, NH I, O 5 Et ⋅ 3HF, Selectfluor, CuI, CuBr, CuCl, LiCl, KBr, NaCl, SOCl Py 9HF, NFSI, TBSCl et al have been recorded how added reagents work will be discussed. We hope review do help future research area.

Language: Английский

Halogenation of Alkenes Using Three‐Component Reactions: A Decade of Development DOI

Rongliang Zeng,

Li Zhang, Dayun Huang

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Abstract Alkenes are valuable feedstocks in organic synthesis. One effective method for synthesizing halides with functional groups close proximity involves the direct difunctionalization of alkenes via three‐component reactions. This approach not only reduces number steps involved synthesis process, but also minimizes waste generation and enables formation complex molecules from simple starting materials. In this review, we mainly discuss decade developments (2013‐2023) two categories: (1) halogenation three‐membered ring intermediates, involving haliranium, thiiranium,seleniranium, aziridinium epoxide species; (2) a radical pathway. Reactions I 2 , BiI 3 NaI, Bu 4 N + [I(O CAr) ] − NIS, NBS, NCS, DBH, BsNMeBr, HBr, HCl, KI, NH I, O 5 Et ⋅ 3HF, Selectfluor, CuI, CuBr, CuCl, LiCl, KBr, NaCl, SOCl Py 9HF, NFSI, TBSCl et al have been recorded how added reagents work will be discussed. We hope review do help future research area.

Language: Английский

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