Cell Death and Disease,
Journal Year:
2019,
Volume and Issue:
10(12)
Published: Dec. 2, 2019
Inflammatory
bowel
disease
(IBD)
is
one
of
the
most
common
diseases
in
gastrointestinal
tract
related
to
aberrant
inflammation.
Pyroptosis,
which
characterized
by
inflammasome
formation,
activation
caspase-1,
and
separation
N-
C-terminals
GSDMD,
might
be
IBD
pathogenesis.
NEK7
an
important
component
NLRP3
macrophages.
We
attempted
investigate
mechanism
interacting
with
modulate
pyroptosis
IBD.
mRNA
protein
expression
pyroptosis-associated
factors,
including
Caspase-1
(p45,
p20),
NLRP3,
were
upregulated
tissues.
knockdown
abolish
ATP
+
LPS-induced
vitro
improved
DSS-induced
chronic
colitis
vivo.
interacted
as
revealed
Co-IP
GST
pull-down
assays,
exert
its
effects.
Moreover,
short-term
LPS
treatment
alone
induced
no
significant
changes
level.
TLR4/NF-κB
signaling
MODE-K
cells
could
activated
treatment.
upregulation
significantly
reversed
JSH-23,
inhibitor
p65.
Furthermore,
LUC
ChIP
assays
that
RELA
activate
transcription
via
targeting
promoter
region.
causes
increase
binding
In
conclusion,
interacts
activation,
therefore
modulating
mice.
provide
a
novel
NEK7-NLRP3
interaction
affecting
pyroptosis.
Signal Transduction and Targeted Therapy,
Journal Year:
2017,
Volume and Issue:
2(1)
Published: July 14, 2017
The
transcription
factor
NF-κB
regulates
multiple
aspects
of
innate
and
adaptive
immune
functions
serves
as
a
pivotal
mediator
inflammatory
responses.
induces
the
expression
various
pro-inflammatory
genes,
including
those
encoding
cytokines
chemokines,
also
participates
in
inflammasome
regulation.
In
addition,
plays
critical
role
regulating
survival,
activation
differentiation
cells
T
cells.
Consequently,
deregulated
contributes
to
pathogenic
processes
diseases.
this
review,
we
will
discuss
function
association
with
diseases
highlight
development
therapeutic
strategies
based
on
inhibition.
Circulation Research,
Journal Year:
2018,
Volume and Issue:
122(6), P. 877 - 902
Published: March 15, 2018
Reactive
oxygen
species
(ROS)
are
well
known
for
their
role
in
mediating
both
physiological
and
pathophysiological
signal
transduction.
Enzymes
subcellular
compartments
that
typically
produce
ROS
associated
with
metabolic
regulation,
diseases
dysfunction
may
be
influenced
by
changes
redox
balance.
In
this
review,
we
summarize
the
current
literature
surrounding
inflammatory
focusing
on
transduction
its
relationship
to
disease
progression.
particular,
examine
production
such
as
cytoplasm,
mitochondria,
peroxisome,
endoplasmic
reticulum
discuss
how
influence
processes
proteasome
function,
autophagy,
general
signaling.
We
also
highlight
of
regulation
metabolic/inflammatory
including
atherosclerosis,
diabetes
mellitus,
stroke.
order
develop
therapies
target
oxidative
signaling,
it
is
vital
understand
balance
signaling
plays
physiology
pathophysiology,
manipulation
identity
cellular
tissue
homeostasis.
An
increased
understanding
specific
sources
an
appreciation
metabolism
help
guide
us
effort
treat
cardiovascular
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: March 29, 2021
Abstract
Currently,
pyroptosis
has
received
more
and
attention
because
of
its
association
with
innate
immunity
disease.
The
research
scope
expanded
the
discovery
gasdermin
family.
A
great
deal
evidence
shows
that
can
affect
development
tumors.
relationship
between
tumors
is
diverse
in
different
tissues
genetic
backgrounds.
In
this
review,
we
provide
basic
knowledge
pyroptosis,
explain
tumors,
focus
on
significance
tumor
treatment.
addition,
further
summarize
possibility
as
a
potential
treatment
strategy
describe
side
effects
radiotherapy
chemotherapy
caused
by
pyroptosis.
brief,
double-edged
sword
for
rational
use
dual
effect
will
help
us
explore
formation
ideas
patients
to
develop
new
drugs
based
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: Aug. 4, 2021
Abstract
Pattern
recognition
receptors
(PRRs)
are
a
class
of
that
can
directly
recognize
the
specific
molecular
structures
on
surface
pathogens,
apoptotic
host
cells,
and
damaged
senescent
cells.
PRRs
bridge
nonspecific
immunity
immunity.
Through
binding
ligands,
produce
anti-infection,
antitumor,
other
immunoprotective
effects.
Most
in
innate
immune
system
vertebrates
be
classified
into
following
five
types
based
protein
domain
homology:
Toll-like
(TLRs),
nucleotide
oligomerization
(NOD)-like
(NLRs),
retinoic
acid-inducible
gene-I
(RIG-I)-like
(RLRs),
C-type
lectin
(CLRs),
absent
melanoma-2
(AIM2)-like
(ALRs).
basically
composed
ligand
domains,
intermediate
effector
domains.
bind
their
respective
ligands
recruit
adaptor
molecules
with
same
structure
through
initiating
downstream
signaling
pathways
to
exert
In
recent
years,
increased
researches
have
greatly
promoted
understanding
different
provided
ideas
for
treatment
immune-related
diseases
even
tumors.
This
review
describes
detail
history,
structural
characteristics,
mechanism,
pathway,
related
disease,
new
drugs
clinical
trials
therapy
PRRs,
discusses
significance
research
pattern
mechanism
PRR-related
diseases.
Journal of Inflammation Research,
Journal Year:
2020,
Volume and Issue:
Volume 13, P. 1057 - 1073
Published: Dec. 1, 2020
Abstract:
Since
the
Great
Oxidation
Event,
about
2.4
billion
years
ago,
Earth
is
immersed
in
an
oxidizing
atmosphere.
Thus,
it
has
been
proposed
that
excess
oxygen,
originally
a
waste
product
of
photosynthetic
cyanobacteria,
induced
oxidative
stress
and
production
reactive
oxygen
species
(ROS),
which
have
since
acted
as
fundamental
drivers
biologic
evolution
eukaryogenesis.
Indeed,
throughout
organism's
lifespan,
ROS
affect
directly
(as
mutagens)
or
indirectly
messengers
regulators)
all
structural
functional
components
cells,
many
aspects
cell
biology.
Whether
left
unchecked
by
protective
antioxidant
systems,
not
only
cause
genomic
mutations
but
also
induce
irreversible
modification
proteins
(protein
oxidation
peroxidation),
lipids
glycans
(advanced
lipoxidation
glycation
end
products),
impairing
their
function
promoting
disease
death.
Conversely,
low-level
local
play
important
role
both
redox-signaling
molecules
wide
spectrum
pathways
involved
maintenance
cellular
homeostasis
(MAPK/ERK,
PTK/PTP,
PI3K-AKT-mTOR),
regulating
key
transcription
factors
(NFκB/IκB,
Nrf2/KEAP1,
AP-1,
p53,
HIF-1).
Consequently,
can
shape
variety
functions,
including
proliferation,
differentiation,
migration
apoptosis.
In
this
review,
we
will
give
brief
overview
relevance
physiological
pathological
processes,
particularly
inflammation
aging.
In-depth
knowledge
molecular
mechanisms
actuation
influence
under
steady-state
stressful
conditions
pave
way
for
development
novel
therapeutic
interventions.
This
mitigate
harmful
outcomes
onset
progression
chronic
inflammatory
age-related
diseases.
Keywords:
species,
stress,
Cellular and Molecular Immunology,
Journal Year:
2021,
Volume and Issue:
18(5), P. 1141 - 1160
Published: April 13, 2021
Abstract
The
NOD-,
LRR-,
and
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome
is
a
multiprotein
complex
involved
in
the
release
of
mature
interleukin-1β
triggering
pyroptosis,
which
paramount
importance
variety
physiological
pathological
conditions.
Over
past
decade,
considerable
advances
have
been
made
elucidating
molecular
mechanisms
underlying
priming/licensing
(Signal
1)
assembly
2)
NLRP3
activation.
Recently,
number
studies
indicated
that
step
regulated
by
complicated
at
both
transcriptional
posttranslational
levels.
In
this
review,
we
discuss
current
understanding
mechanistic
details
activation
with
particular
emphasis
on
protein-protein
interactions,
modifications,
spatiotemporal
regulation
machinery.
We
also
present
detailed
summary
multiple
positive
and/or
negative
regulatory
pathways
providing
upstream
signals
culminate
assembly.
A
better
will
provide
opportunities
for
development
methods
prevention
treatment
inflammasome-related
diseases.
