New Insights on the Use of Polyphenols as Natural Preservatives and Their Emerging Safety Concerns DOI Creative Commons
Fred Kwame Ofosu,

Eric Banan‐Mwine Daliri,

Fazle Elahi

et al.

Frontiers in Sustainable Food Systems, Journal Year: 2020, Volume and Issue: 4

Published: Nov. 10, 2020

Polyphenols are natural high-valued secondary metabolites of plant that demonstrate strong antimicrobial potential as preservatives besides their well-established health promoting benefits. This review highlights the challenges, novel strategies to achieve industrial production polyphenols and safe use alternative preservative. Since extraction presents considerable limitations high cost due excessive energy solvent requirements, climate long growth cycles, microbial biosynthesis using highly advanced omics techniques metabolic engineering tools could provide superior for commercial environmentally sustainable cost-effective high-value in a short time. In spite many beneficial effects, some polyphenol compounds at dosage found be pro-oxidant or mutagenic with toxicity. Due controversial findings from sub-chronic oral toxicity studies, more detailed safety efficacy studies needed substantiate findings. Furthermore, extensive research efforts required ascertain optimal various foods avoid harmful side effects.

Language: Английский

Bacterial biopolymers: from pathogenesis to advanced materials DOI Open Access
M. Fata Moradali, Bernd H. A. Rehm

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 18(4), P. 195 - 210

Published: Jan. 28, 2020

Language: Английский

Citations

378
Metabolic Engineering of Escherichia coli for Natural Product Biosynthesis DOI
Dongsoo Yang,

Seon Young Park,

Yae Seul Park

et al.

Trends in biotechnology, Journal Year: 2020, Volume and Issue: 38(7), P. 745 - 765

Published: Jan. 7, 2020

Language: Английский

Citations

285
Machine learning for metabolic engineering: A review DOI Creative Commons
Christopher E. Lawson, Jose Manuel Martí, Tijana Radivojević

et al.

Metabolic Engineering, Journal Year: 2020, Volume and Issue: 63, P. 34 - 60

Published: Nov. 20, 2020

Machine learning provides researchers a unique opportunity to make metabolic engineering more predictable. In this review, we offer an introduction discipline in terms that are relatable engineers, as well providing in-depth illustrative examples leveraging omics data and improving production. We also include practical advice for the practitioner of management, algorithm libraries, computational resources, important non-technical issues. A variety applications ranging from pathway construction optimization, genetic editing cell factory testing, production scale-up discussed. Moreover, promising relationship between machine mechanistic models is thoroughly reviewed. Finally, future perspectives most directions combination disciplines examined.

Language: Английский

Citations

210
Industrial biotechnology of Pseudomonas putida: advances and prospects DOI Creative Commons

Anna Weimer,

Michael Kohlstedt, Daniel C. Volke

et al.

Applied Microbiology and Biotechnology, Journal Year: 2020, Volume and Issue: 104(18), P. 7745 - 7766

Published: Aug. 13, 2020

Abstract Pseudomonas putida is a Gram-negative, rod-shaped bacterium that can be encountered in diverse ecological habitats. This ubiquity traced to its remarkably versatile metabolism, adapted withstand physicochemical stress, and the capacity thrive harsh environments. Owing these characteristics, there growing interest this microbe for industrial use, corresponding research has made rapid progress recent years. Hereby, strong drivers are exploitation of cheap renewable feedstocks waste streams produce value-added chemicals steady genetic strain engineering systems biology understanding bacterium. Here, we summarize advances prospects engineering, synthetic biology, applications P. as cell factory. Key points • global Novel tools enable system-wide streamlined genomic engineering. Applications range from bioeconomy biosynthetic drugs.

Language: Английский

Citations

191
Machine learning applications in systems metabolic engineering DOI
Gi Bae Kim, Won Jun Kim, Hyun Uk Kim

et al.

Current Opinion in Biotechnology, Journal Year: 2019, Volume and Issue: 64, P. 1 - 9

Published: Sept. 30, 2019

Language: Английский

Citations

152
Biosynthesis of inorganic nanomaterials using microbial cells and bacteriophages DOI
Yoojin Choi, Sang Yup Lee

Nature Reviews Chemistry, Journal Year: 2020, Volume and Issue: 4(12), P. 638 - 656

Published: Oct. 5, 2020

Language: Английский

Citations

143
Designing Microbial Cell Factories for the Production of Chemicals DOI Creative Commons
Jae Sung Cho, Gi Bae Kim, Hyunmin Eun

et al.

JACS Au, Journal Year: 2022, Volume and Issue: 2(8), P. 1781 - 1799

Published: Aug. 4, 2022

The sustainable production of chemicals from renewable, nonedible biomass has emerged as an essential alternative to address pressing environmental issues arising our heavy dependence on fossil resources. Microbial cell factories are engineered microorganisms harboring biosynthetic pathways streamlined produce interests renewable carbon sources. for the can be defined into three categories with reference microbial host selected engineering: native-existing pathways, nonnative-existing and nonnative-created pathways. Recent trends in leveraging discovering designing de novo (as pathways) discussed this Perspective. We highlight key approaches successful case studies that exemplify these concepts. Once designed constructed factory, systems metabolic engineering strategies used improve performance strain meet industrial standards. In second part Perspective, current design tools eye toward future. Finally, we survey future challenges need addressed advance chemicals.

Language: Английский

Citations

122
Polyhydroxyalkanoates synthesis by halophiles and thermophiles: towards sustainable production of microbial bioplastics DOI
Stanislav Obruča, Pavel Dvořák, Petr Sedláček

et al.

Biotechnology Advances, Journal Year: 2022, Volume and Issue: 58, P. 107906 - 107906

Published: Jan. 13, 2022

Language: Английский

Citations

87
Bioprocess intensification: A route to efficient and sustainable biocatalytic transformations for the future DOI Creative Commons
Kamelia Boodhoo, Michael C. Flickinger, John M. Woodley

et al.

Chemical Engineering and Processing - Process Intensification, Journal Year: 2022, Volume and Issue: 172, P. 108793 - 108793

Published: Jan. 10, 2022

With the current pressing need to rise ambition of net zero targets mitigate carbon emissions and climate change impacts, sustainable processing has never been more critical. Bioprocessing all desirable attributes respond challenge: use cheap, renewable resources, nature-inspired, highly selective biocatalysts operating optimally under mild conditions reduced energy consumption/carbon footprint. bioprocessing productivity being far from ideal meet large-scale for food, drugs, biofuels bio-based chemicals, there tremendous interest late in developing intensified bioprocesses, with significant advancement achieved tailoring utilising technologies toolbox traditionally applied chemical process intensification. This review highlights wide range activities currently on-going bioprocess intensification, focusing on upstream, bioreactor/fermentation downstream separation steps. Great strides have made biocatalyst engineering high density cell immobilisation enhancement, which, conjunction elegant innovations such as novel bioreactor in-situ product separations, are enabling bioprocesses become competitive than ever before. The future prospects intensification promising but still challenges that be overcome fully exploit this technology.

Language: Английский

Citations

78
Emerging Trends in Genetic Engineering of Microalgae for Commercial Applications DOI Creative Commons
Samir B. Grama, Zhiyuan Liu, Jian Li

et al.

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(5), P. 285 - 285

Published: April 24, 2022

Recently, microalgal biotechnology has received increasing interests in producing valuable, sustainable and environmentally friendly bioproducts. The development of economically viable production processes entails resolving certain limitations biotechnology, fast evolving genetic engineering technologies have emerged as new tools to overcome these limitations. This review provides a synopsis recent progress, current trends emerging approaches microalgae for commercial applications, including pharmaceutical protein, lipid, carotenoids biohydrogen, etc. Photochemistry improvement CO2 sequestration by via were also discussed since subjects are closely entangled with the above mentioned products. Although is proved be very effective boosting performance laboratory conditions, only limited success was achieved applicable industry so far. With advancing rapidly intensive investigations going on, more bioproducts expected produced genetically modified even much prospected.

Language: Английский

Citations

75