Polymers,
Journal Year:
2022,
Volume and Issue:
14(22), P. 4996 - 4996
Published: Nov. 18, 2022
Plastic
production
worldwide
has
doubled
in
the
last
two
decades
and
is
expected
to
reach
a
four-fold
increase
by
2050.
The
durability
of
plastic
makes
them
perfect
material
for
many
applications,
but
it
also
key
limitation
their
end-of-life
management.
current
lifecycle
far
from
circular,
with
only
13%
being
collected
recycling
9%
successfully
recycled,
indicating
failure
technology.
remaining
waste
streams
are
thus
incinerated,
landfilled,
or
worse,
mismanaged,
leading
leaking
into
environment.
To
promote
circularity,
keeping
loop
priority
represents
more
sustainable
solution.
This
can
be
achieved
through
reuse
items,
using
as
resource
new
materials,
instead
discarding
waste.
As
discovery
plastic-degrading/utilizing
microorganisms
enzymes
been
extensively
reported
recently,
possibility
developing
biological
upcycling
processes
opening
up.
An
increasing
amount
studies
have
investigated
use
carbon
source
biotechnological
produce
high-value
compounds
such
bioplastics,
biochemicals,
biosurfactants.
In
review,
advancements
fossil-based
bio-
thermochemical
technologies
presented
critically
discussed.
particular,
we
highlight
developed
(bio)depolymerization
coupled
bioconversion/fermentation
obtain
industrially
valuable
products.
review
contribute
future
development
scale-up
effective
bioupcycling
that
act
drive
removal
environment
valorize
post-consumer
streams,
accelerating
implementation
circular
(plastic)
economy.
Biotechnology Advances,
Journal Year:
2022,
Volume and Issue:
60, P. 107991 - 107991
Published: May 31, 2022
The
global
production
of
plastics
has
continuously
been
soaring
over
the
last
decades
due
to
their
extensive
use
in
our
daily
life
and
industries.
Although
synthetic
offer
great
advantages
from
packaging
construction
electronics,
low
biodegradability
induce
serious
plastic
pollution
that
damage
environment,
human
health
make
irreversible
changes
ecological
cycle.
In
particular,
containing
only
carbon-carbon
(C-C)
backbone
are
less
susceptible
degradation
lack
hydrolysable
groups.
representative
polyethylene
(PE)
polystyrene
(PS)
account
for
about
40%
total
production.
Various
chemical
biological
processes
with
potential
have
developed
recycle
reuse,
but
biodegradation
seems
be
most
attractive
eco-friendly
method
combat
this
growing
environmental
problem.
review,
we
first
summarize
current
advances
PE
PS
biodegradation,
including
isolation
microbes
degrading
enzymes
different
sources.
Next,
state-of-the-art
techniques
used
evaluating
monitoring
degradation,
scientific
toolboxes
enzyme
discovery
as
well
challenges
strategies
intensively
discussed.
return,
it
inspires
a
further
technological
exploration
expanding
diversity
species
enzymes,
disclosing
essential
pathways
developing
new
approaches
utilize
waste
feedstock
recycling
upcycling.
Journal of Hazardous Materials,
Journal Year:
2022,
Volume and Issue:
436, P. 129278 - 129278
Published: June 3, 2022
Polyethylene
(PE)
is
one
of
the
most
recalcitrant
carbon-based
synthetic
materials
produced
and,
currently,
ubiquitous
plastic
pollutant
found
in
nature.
Over
time,
combined
abiotic
and
biotic
processes
are
thought
to
eventually
breakdown
PE.
Despite
limited
evidence
biological
PE
degradation
speculation
that
hydrocarbon-degrading
bacteria
within
plastisphere
an
indication
biodegradation,
there
no
clear
mechanistic
understanding
process.
Here,
using
high-throughput
proteomics,
we
investigated
molecular
take
place
marine
bacterium
Alcanivorax
sp.
24
when
grown
presence
low
density
(LDPE).
As
well
as
efficiently
utilising
assimilating
leachate
weathered
LDPE,
was
able
reduce
weight
distribution
(Mw
from
122
83
kg/mol)
overall
mass
pristine
LDPE
films
(0.9
%
after
34
days
incubation).
Most
interestingly,
acquired
isotopic
signature
induced
extensive
array
metabolic
pathways
for
aliphatic
compound
degradation.
Presumably,
primary
biodegradation
by
possible
via
production
extracellular
reactive
oxygen
species
observed
both
material's
surface
oxidation
measurement
superoxide
culture
with
LDPE.
Our
findings
confirm
hydrocarbon-biodegrading
may
fact
have
a
role
degrading
PROTEOMICS,
Journal Year:
2022,
Volume and Issue:
23(17)
Published: Nov. 16, 2022
Abstract
Arguably,
2020
was
the
year
of
high‐accuracy
protein
structure
predictions,
with
AlphaFold
2.0
achieving
previously
unseen
accuracy
in
Critical
Assessment
Protein
Structure
Prediction
(CASP).
In
2021,
DeepMind
and
EMBL‐EBI
developed
Database
to
make
an
unprecedented
number
reliable
predictions
easily
accessible
broad
scientific
community.
We
provide
a
brief
overview
describe
latest
developments
database.
highlight
how
fields
data
services,
bioinformatics,
structural
biology,
drug
discovery
are
directly
affected
by
influx
data.
also
show
examples
cutting‐edge
research
that
took
advantage
It
is
apparent
connections
between
various
through
structures
now
possible,
but
amount
poses
new
challenges.
Finally,
we
give
outlook
regarding
future
direction
database,
both
terms
sets
functionalities.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(3), P. 2658 - 2677
Published: March 21, 2024
Microplastics
and
nanoplastics
(MNPs)
are
becoming
an
increasingly
severe
global
problem
due
to
their
widespread
distribution
complex
impact
on
living
organisms.
Apart
from
environmental
impact,
the
effects
of
MNPs
organisms
have
also
continued
attract
attention.
The
harmful
has
been
extensively
documented
in
marine
invertebrates
larger
vertebrates
like
fish.
However,
research
toxicity
these
particles
mammals
is
still
limited,
possible
humans
poorly
understood.
Considering
that
commonly
found
food
or
packaging,
primarily
exposed
them
through
ingestion.
It
would
be
valuable
investigate
potential
gut
health.
This
review
focuses
recent
exploring
toxicological
impacts
micro-
gut,
as
observed
human
cell
lines
mammalian
models.
Available
data
various
studies
indicate
accumulation
models
cells
may
result
adverse
consequences,
terms
epithelial
toxicity,
immune
disruption
microbiota.
paper
discusses
current
limitations
prospects
this
field,
aiming
provide
a
scientific
basis
reference
for
further
toxic
mechanisms
nanoplastics.
