International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11451 - 11451
Published: Oct. 25, 2024
Sarcopenia
is
a
systemic
medical
disorder
characterized
by
gradual
decline
in
muscular
strength,
function,
and
skeletal
muscle
mass.
Currently,
there
no
medication
specifically
approved
for
the
treatment
of
this
condition.
Therefore,
identification
new
pharmacological
targets
may
offer
opportunities
development
novel
therapeutic
strategies.
The
current
silico
study
investigated
active
ingredients
mode
action
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1934 - 1934
Published: June 18, 2024
Physical
fatigue
(peripheral
fatigue),
which
affects
a
considerable
portion
of
the
world
population,
is
decline
in
ability
muscle
fibers
to
contract
effectively
due
alterations
regulatory
processes
action
potentials.
However,
it
lacks
an
efficacious
therapeutic
intervention.
The
present
study
explored
bioactive
compounds
and
mechanism
Citrus
reticulata
peel
(CR-P)
treating
physical
by
utilizing
network
pharmacology
(NP),
molecular
docking,
simulation-based
dynamics
(MD).
ingredients
CR-P
prospective
targets
were
obtained
from
various
databases.
A
PPI
was
generated
STRING
database,
while
key
overlapping
analyzed
for
enrichment
adopting
KEGG
GO.
binding
affinities
hub
determined
docking.
results
further
validated
MD
simulation.
Five
screened,
56
identified
fatigue,
whereas
with
greater
degree
AKT1,
TP53,
STAT3,
MTOR,
KRAS,
HRAS,
JAK2,
IL6,
EGFR,
ESR1.
findings
analysis
indicated
significant
three
signaling
pathways,
namely
PI3K-AKT,
MAPK,
JAK-STAT.
docking
simulation
revealed
that
exhibit
stronger
affinity
interacting
targets.
work
suggests
CR-P,
specifically
Hesperetin
Sitosterol,
may
ameliorate
via
PI3K-AKT
pathway
targeting
MTOR
proteins.
Food Science & Nutrition,
Journal Year:
2024,
Volume and Issue:
12(12), P. 9974 - 9997
Published: Nov. 7, 2024
ABSTRACT
Citrus
peels
are
rich
in
bioactive
phenolic
compounds
with
various
health
effects
including
antioxidant,
antiobesity,
antiinflammatory,
antihypertensive,
antihypercholesterolemic,
antimicrobial,
antidiabetic,
and
anticarcinogenic
activities.
Both
extractable
nonextractable
phenolics
present
significant
amounts
peel
diverse
bioactivities.
While
can
be
recovered
from
the
fruit
by
conventional
extraction
methods,
remaining
residues
must
released
cell
matrix
first
hydrolysis
acid,
alkali,
or
enzymes.
Novel
processing
technologies
help
improvement
of
efficiency.
Extreme
process
medium
conditions
degrade
their
bioactivity
where
encapsulation
applied
to
improve
stability,
solubility,
bioactivity.
powder
ascorbic
acid
dietary
fiber
besides
extracts
therefrom
used
as
functional
food
ingredients
extend
shelf
life
provide
benefits.
In
addition,
antioxidant
antimicrobial
agents
active
packaging
applications.
Phenolic
have
also
a
potential
nutraceuticals
pharmaceuticals.
this
review,
different
forms
peels,
recovery,
possible
applications
for
upcycling
industry
presented.
BIO Web of Conferences,
Journal Year:
2024,
Volume and Issue:
113, P. 05013 - 05013
Published: Jan. 1, 2024
The
aim
of
the
study
was
to
investigate
reparative
processes
and
immune
mechanisms
in
rat
liver
tissues
against
background
loading
with
aqueous
extracts
blackberry
common
sawfly
induced
oxidative
stress.
120
rats
were
used
experiment.
According
group
affiliation
animals
received
a
dose
50
mg/100g
weight,
1.5
ml
daily
for
30
days,
control
distilled
water
same
mode.
Starting
from
days
experiment,
injected
CCl4
6
days.
On
37th
day
killed
according
ethical
standards.
number
sinusoidal
cells
counted
tissues.
content
cytokines
homogenates
blood
plasma
determined
by
enzyme-linked
immunosorbent
assay.
Conclusion.
Aqueous
fir
modulate
different
degrees
functional
state
early
periods
toxic
exposure
tetrachloromethane,
which
contributes
resolution
inflammatory
process.
Exposure
changes
production
regulatory
factors,
compensates
speed
recovery
after
exposure.
