Inhibition and impulsivity: Behavioral and neural basis of response control

Progress in Neurobiology, Journal Year: 2013, Volume and Issue: 108, P. 44 - 79

Published: July 13, 2013

Language: Английский

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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Annual Review of Psychology, Journal Year: 2015, Volume and Issue: 67(1), P. 23 - 50

Published: Aug. 8, 2015

A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational use to compulsive drug-seeking habits, neurally underpinned by prefrontal cortical striatal control over seeking and taking well progression the ventral dorsal striatum. Here, in light of burgeoning, supportive evidence, reconsider elaborate this hypothesis, particular refinements our understanding mechanisms underlying goal-directed habitual seeking, influence drug-associated Pavlovian-conditioned stimuli on relapse, evidence for impairments top-down inhibitory behavior. We further review animal human studies have begun define etiological factors individual differences propensity become addicted drugs, leading description endophenotypes, especially cocaine addiction. consider prospect novel treatments promote abstinence relapse use.

Language: Английский

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Computational psychiatry as a bridge from neuroscience to clinical applications

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(3), P. 404 - 413

Published: Feb. 23, 2016

Language: Английский

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Reflecting on rumination: Consequences, causes, mechanisms and treatment of rumination

Behaviour Research and Therapy, Journal Year: 2020, Volume and Issue: 127, P. 103573 - 103573

Published: Jan. 31, 2020

Language: Английский

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Characterizing a psychiatric symptom dimension related to deficits in goal-directed control

eLife, Journal Year: 2016, Volume and Issue: 5

Published: Feb. 15, 2016

Prominent theories suggest that compulsive behaviors, characteristic of obsessive-compulsive disorder and addiction, are driven by shared deficits in goal-directed control, which confers vulnerability for developing rigid habits. However, recent studies have shown deficient control accompanies several disorders, including those without an obvious element. Reasoning this lack clinical specificity might reflect broader issues with psychiatric diagnostic categories, we investigated whether a dimensional approach would better delineate the manifestations deficits. Using large-scale online assessment symptoms neurocognitive performance two independent general-population samples, found were most strongly associated symptom dimension comprising behavior intrusive thought. This association was highly specific when compared to other non-compulsive aspects psychopathology. These data showcase powerful new methodology highlight potential dimensional, biologically-grounded psychiatry research.

Language: Английский

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New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity

CNS Spectrums, Journal Year: 2014, Volume and Issue: 19(1), P. 69 - 89

Published: Feb. 1, 2014

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated risk-seeking harm-avoidance. However, they increasingly recognized to be linked shared neuropsychological mechanisms involving dysfunctional inhibition thoughts behaviors. In this article, we selectively review new developments in the investigation neurocognition humans, order advance our understanding pathophysiology impulsive, compulsive, addictive disorders indicate directions for research.

Language: Английский

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Obesity and the brain: how convincing is the addiction model?

Nature reviews. Neuroscience, Journal Year: 2012, Volume and Issue: 13(4), P. 279 - 286

Published: March 14, 2012

Language: Английский

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Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review

Neuron, Journal Year: 2018, Volume and Issue: 98(5), P. 886 - 903

Published: June 1, 2018

Language: Английский

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Neuropsychosocial profiles of current and future adolescent alcohol misusers

Nature, Journal Year: 2014, Volume and Issue: 512(7513), P. 185 - 189

Published: July 1, 2014

Language: Английский

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Canceling actions involves a race between basal ganglia pathways

Nature Neuroscience, Journal Year: 2013, Volume and Issue: 16(8), P. 1118 - 1124

Published: July 14, 2013

Language: Английский

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