Precise Timing Matters: Modulating Human Memory by Synchronizing Hippocampal Stimulation to Saccadic Event Related Potentials DOI Creative Commons
Chaim N. Katz, Kramay Patel, Andrea Gómez Palacio Schjetnan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 13, 2024

Abstract Episodic memory, the ability to record and relive experiences, is intricately connected visual exploration in most humans. This study explores possibility that eye movements create physiological states relevant for analogous those associated with hippocampal theta. Previous work has demonstrated saccadic movements, which occur roughly at theta frequency, elicit event-related potentials (ERPs). Building on Separate Phases of Encoding Retrieval (SPEAR) model, we asked if peaks troughs this ERP are differentially important memory formation. Specifically, applied saccade-contingent electrical stimulation estimated while individuals epilepsy visually explored natural scenes across 59 sessions. We subsequently assessed their recognition recall targets. Results indicate robust when precisely targets peak or trough, contrasting impairments observed random stimulation. Moreover, impairment prominent within 100 ms saccade initiation, a time reflects high medial temporal lobe inhibition. Our findings suggest hippocampus rapidly evolves through memory-relevant following each movement, also challenging assumption human mirror encoding retrieval phases rhythms studied rodents. The sheds light dynamic interplay between activity, formation, offering theoretical insights potential applications modulation neurological disorders. Significance Statement Why do eye-movements enhance formation? Here, causally tested initiate short-lived critical formation hippocampus, brain region known support memory. built system could apply key moments after test how timing influenced people’s form memories. found was particularly disruptive initiating an movement. By contrast, timed trough eye-movement responses. interpret evolution model relate rodent

Language: Английский

Eye-movement replay supports episodic remembering DOI Creative Commons
Roger Johansson, Marcus Nyström,

Richard Dewhurst

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2022, Volume and Issue: 289(1977)

Published: June 15, 2022

When we bring to mind something have seen before, our eyes spontaneously unfold in a sequential pattern strikingly similar that made during the original encounter, even absence of supporting visual input. Oculomotor movements eye may then serve opposite purpose acquiring new information; they as self-generated cues, pointing stored memories. Over 50 years ago Donald Hebb, forefather cognitive neuroscience, posited such replay supports ability mentally recreate visuospatial relations episodic remembering. However, direct evidence for this influential claim is lacking. Here isolate properties spontaneous encoding and retrieval pure recall memory task capture their encoding-retrieval overlap. Critically, show fidelity with which series consecutive from initial sequentially retained subsequent predicts quality recalled memory. Our findings provide scanpaths are replayed assemble reconstruct spatio-temporal remember further suggest distinct scanpath differentially contribute depending on nature goal-relevant

Language: Английский

Citations

31
Saccades are locked to the phase of alpha oscillations during natural reading DOI Creative Commons
Yali Pan, Tzvetan Popov, Steven Frisson

et al.

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(1), P. e3001968 - e3001968

Published: Jan. 17, 2023

We saccade 3 to 5 times per second when reading. However, little is known about the neuronal mechanisms coordinating oculomotor and visual systems during such rapid processing. Here, we ask if brain oscillations play a role in temporal coordination of visuomotor integration. simultaneously acquired MEG eye-tracking data while participants read sentences silently. Every sentence was embedded with target word either high or low lexical frequency. Our key finding demonstrated that onsets were locked phase alpha (8 13 Hz), particular, for saccades towards frequency words. Source modelling which locked, generated right-visual motor cortex (BA 7). findings suggest serve time processing between natural reading, this becomes more pronounced demanding

Language: Английский

Citations

21
Entorhinal grid-like codes and time-locked network dynamics track others navigating through space DOI Creative Commons
Isabella C. Wagner, Luise P. Graichen, Boryana Todorova

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 31, 2023

Abstract Navigating through crowded, dynamically changing environments requires the ability to keep track of other individuals. Grid cells in entorhinal cortex are a central component self-related navigation but whether they also others’ movement is unclear. Here, we propose that grid-like codes make an essential contribution socio-spatial navigation. Sixty human participants underwent functional magnetic resonance imaging (fMRI) while observing and re-tracing different paths demonstrator navigated virtual reality environment. Results revealed tracked individual navigating space. The activity was time-locked increases co-activation entorhinal-cortical connectivity included striatum, hippocampus, parahippocampal right posterior parietal cortices. Surprisingly, grid-related effects during observation were stronger worse performed when subsequently demonstrator’s paths. Our findings suggests network dynamics grid-cell-related might serve distribute information about location others throughout brain.

Language: Английский

Citations

13
Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease DOI Creative Commons

Rachelle L. Pulver,

Eugene Kronberg,

Lindsey M. Medenblik

et al.

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 20(1), P. 301 - 315

Published: Aug. 23, 2023

Abstract INTRODUCTION Memory‐associated neural circuits produce oscillatory events including theta bursts (TBs), sleep spindles (SPs), and slow waves (SWs) in electroencephalography (EEG). Changes the “coupling” of these may indicate early Alzheimer's disease (AD) pathogenesis. METHODS We analyzed 205 aging adults using single‐channel EEG, cerebrospinal fluid (CSF) AD biomarkers, Clinical Dementia Rating® (CDR®) scale. mapped SW‐TB SW‐SP circuit coupling precision to amyloid positivity, cognitive impairment, CSF biomarkers. RESULTS Cognitive impairment correlated with lower TB spectral power coupling. Cognitively unimpaired, positive individuals demonstrated compared negative individuals. Significant biomarker correlations were found event Aβ 42 /Aβ 40 , phosphorylated‐ tau 181 total‐tau. DISCUSSION Sleep‐dependent memory processing integrity can be measured for both This breakdown associates increased pathology, impairment. Highlights At‐home EEG is a potential linked memory. Circuit associated positivity asymptomatic adults. Levels also correlate EEG. Theta burst decreased very mild technique enable inexpensive wearable EEGs monitoring brain health.

Language: Английский

Citations

12
Memory and consciousness DOI
Deborah E. Hannula

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 553 - 569

Published: March 18, 2024

Language: Английский

Citations

4
Gaze dynamics during natural scene memorization and recognition DOI Creative Commons
Puneeth N. Chakravarthula,

Jacob Suffridge,

Shuo Wang

et al.

Cognition, Journal Year: 2025, Volume and Issue: 259, P. 106098 - 106098

Published: March 6, 2025

Language: Английский

Citations

0
Refixation behavior in naturalistic viewing: Methods, mechanisms, and neural correlates DOI Creative Commons
Andrey R. Nikolaev,

Radha Nila Meghanathan,

Cees van Leeuwen

et al.

Attention Perception & Psychophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 2, 2024

Abstract When freely viewing a scene, the eyes often return to previously visited locations. By tracking eye movements and coregistering EEG, such refixations are shown have multiple roles: repairing insufficient encoding from precursor fixations, supporting ongoing by resampling relevant locations prioritized aiding construction of memory representations. All these functions refixation behavior understood be underpinned three oculomotor cognitive systems their associated brain structures. First, immediate saccade planning prior involves attentional selection candidate revisit. This process is likely supported dorsal network. Second, visual working memory, involved in maintaining task-related information, cortex. Third, higher-order relevance scene locations, which depends on general knowledge understanding meaning, hippocampal system. Working together, structures bring about that balances exploring unvisited areas with exploiting through refixations.

Language: Английский

Citations

3
Autobiographical Implicit Association Test and eye movements: fixations topography enables detection of autobiographical memories DOI Creative Commons
Andrea Zangrossi,

Liisa Camilla Gatto,

Virginia Lanfranchi

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 29, 2024

Introduction Autobiographical memory is the capacity to recollect memories of personally experienced events. The detection such plays a key role in criminal trials. Among behavioral memory-detection methods, autobiographical Implicit Association Test (aIAT) has gained popularity for its flexibility and suitability forensic applications. aIAT reaction time-based methodology aiming assess whether information about an event encoded respondent’s mind. Here, we introduced eye-D index, measure based on topography fixations while performing aIAT, as additional detect covertly. Methods In this study, participants were involved mock-crime experiment which they could act Guilty or Innocent. One week later all underwent combined with eye-tracking investigate presence crime-related memory. Results showed higher number towards category labels block true sentences shared same response sentences, compared paired describing alternative version. Innocent opposite pattern. This unbalanced allocation attention was quantified by index found be highly correlated standard aIAT-D index. Discussion suggests that more indicate increased cognitive load monitoring conflicts. These preliminary results highlight tool covertly aIAT.

Language: Английский

Citations

3
Overlapping and distinct phenotypic profiles in Alzheimer’s disease and late onset epilepsy: a biologically-based approach DOI Creative Commons
Anli Liu, William Barr

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: March 13, 2024

Due to shared hippocampal dysfunction, patients with Alzheimer’s dementia and late-onset epilepsy (LOE) report memory decline. Multiple studies have described the epidemiological, pathological, neurophysiological, behavioral overlap between Disease LOE, implying a bi-directional relationship. We describe neurobiological decline occurring at different spatial in AD LOE patients, which may explain why their phenotypes differ. provide suggestions for clinical recognition of dual presentation novel approaches testing that reflect an “inside-out,” or biologically-based approach memory. New language assessments could detect—and treat—memory impairment earlier, actionable stage.

Language: Английский

Citations

3
Investigating the suitability of online eye tracking for psychological research: Evidence from comparisons with in-person data using emotion–attention interaction tasks DOI
Paul C. Bogdan, Sanda Dolcos, Simona Buetti

et al.

Behavior Research Methods, Journal Year: 2023, Volume and Issue: 56(3), P. 2213 - 2226

Published: June 20, 2023

Language: Английский

Citations

8