NEUROBIOLOGICAL AND PSYCHOPHYSIOLOGICAL DIFFERENCES OF VISUAL WORKING MEMORY FUNCTIONING IN RADAR STATION OPERATORS DOI Open Access
O.I. Podkovka,

Mykola Makarchuk,

Наталя Філімонова

et al.

Fìzìologìčnij žurnal, Journal Year: 2023, Volume and Issue: 69(6), P. 22 - 32

Published: Nov. 10, 2023

Operators are often subjected to a high working memory load as far any possibly useful information must always be available and presented the operator. Thus, we assumed that they may have developed adaptations in mechanisms of realization help them more efficient overload conditions. Our aim was define differences visual functioning radar station operators (RSO) other military profession representatives. For this purpose, parallel with performance original computer tests for identification, which had two levels complexity, recorded an electroencephalogram subsequent coherent LORETA analysis electrocardiogram determining stress index regulatory systems. It found reaction time, well number errors both tests, didn`t differ significantly groups. At same control group higher θ-band connections frontal lobe could indicate level mental emotional involvement. This assumption confirmed by dynamic group. showed RSO group, degree fronto-parietal, cingulo-opercular networks, cuneus precuneus involvement at from very first tasks, while it increased task is evidence adaptive changes RSO, due successfully cope overload.

Language: Английский

Neural circuits regulating visceral pain DOI Creative Commons
Xiaoli Chang, Haiyan Zhang, S.R. Wayne Chen

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: April 13, 2024

Abstract Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development chronic visceral pain, which is major challenge for both patients and health providers. Neural circuits in brain encode, store, transfer pain information across regions. In this review, we focus on anterior cingulate cortex paraventricular nucleus hypothalamus highlight progress identifying neural involved pain. We also discuss several circuit mechanisms emphasize importance cross-species, multiangle approaches identification specific neurons determining that control

Language: Английский

Citations

9
Single-cell spatial transcriptome atlas and whole-brain connectivity of the macaque claustrum DOI Creative Commons
Ying Lei, Yuxuan Liu, Mingli Wang

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Claustrum orchestrates brain functions via its connections with numerous regions, but molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, most glutamatergic neurons similar to deep-layer insular neurons. Comparison macaque, marmoset, mouse transcriptomes revealed macaque-specific types. Retrograde tracer injections at 67 cortical 7 subcortical regions defined four distinct distribution zones retrogradely labeled Joint analysis whole-brain connectivity single-cell spatial transcriptome showed that these containing compositions (but not GABAergic) types preferentially connected specific a strong ipsilateral bias. Several in ventral vs. dorsal selectively co-projected two functionally related areas-entorhinal cortex hippocampus motor putamen, respectively. These data provide the basis for elucidating neuronal underlying diverse functions.

Language: Английский

Citations

1
Pain-induced adaptations in the claustro-cingulate pathway DOI Creative Commons
Niels R. Ntamati, Mario A. Acuña, Thomas Nevian

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(5), P. 112506 - 112506

Published: May 1, 2023

Persistent pain is a prevalent medical concern correlating with hyperexcitable anterior cingulate cortex (ACC). Its activity modulated by inputs from several brain regions, but the maladjustments that these afferent circuits undergo during transition acute to chronic still require clarification. We focus on ACC-projecting claustrum (CLAACC) neurons and their responses sensory aversive stimuli in mouse model of inflammatory pain. Using chemogenetics, vivo calcium imaging, ex electrophysiological approaches, we reveal suppression CLAACC acutely attenuates allodynia preferentially transmits information ACC. With prolonged pain, claustro-cingulate functional impairment develops, which mediated weakened excitatory drive onto ACC pyramidal neurons, resulting diminished claustral influence These findings support an instrumental role processing nociceptive its susceptibility persistent states.

Language: Английский

Citations

18
A simple and reliable method for claustrum localization across age in mice DOI Creative Commons
Tarek Shaker,

Gwyneth J. Dagpa,

Vanessa Cattaud

et al.

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Feb. 17, 2024

Abstract The anatomical organization of the rodent claustrum remains obscure due to lack clear borders that distinguish it from neighboring forebrain structures. Defining what constitutes is imperative for elucidating its functions. Methods based on gene/protein expression or transgenic mice have been used spatially outline but often report incomplete labeling and/or specificity during certain neurodevelopmental timepoints. To reliably identify projection cells in mice, we propose a simple immunolabelling method juxtaposes pattern claustrum-enriched and cortical-enriched markers. We determined immunoreactive markers Nurr1 Nr2f2 are devoid cortical marker Tle4, which allowed us differentiate adjoining cells. Using retrograde tracing, verified nearly all neurons Tle4 expressed Nurr1/Nr2f2 different degrees. At neonatal stages between 7 21 days, were identified by their Nurr1-postive/Tle4-negative profile, time-period when other techniques localize adult ineffective. Finally, exposure environmental novelty enhanced neuronal activation c-Fos region. Notably, was mainly restricted Nurr1-positive absent Tle4-positive cells, thus corroborating previous work reporting novelty-induced activation. Taken together, this will aid studying postnatal development may improve histological functional studies where approaches not amenable.

Language: Английский

Citations

7
The functional connectivity of the human claustrum, according to the Human Connectome Project database DOI Creative Commons

Lluviana Rodríguez-Vidal,

Sarael Alcauter, Fernando A. Barrios

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0298349 - e0298349

Published: April 18, 2024

The claustrum is an irregular and fine sheet of grey matter in the basolateral telencephalon present almost all mammals. has been object several studies using animal models and, more recently, human beings neuroimaging. One most extended cognitive processes attributed to salience process, which also related insular cortex. In same way, with subjects functional magnetic resonance imaging have reported coactivation claustrum/insular cortex integration sensory signals. This left or right asymmetry task literature neurological disorders such as Alzheimer's disease schizophrenia, relating severity delusions reduction claustral volume. We a connectivity study claustrum. Resting-state anatomical MRI data from 100 healthy were analyzed; taken Human Connectome Project (HCP, NIH Blueprint: Project), 2x2x2 mm3 voxel resolution. hypothesize that 1) node involved different brain networks, 2) pattern cortex's pattern, 3) claustrum's connectivity. Our findings include at least three networks found between claustrum, frontoparietal network, default mode network distinctive attribute. dorsal attention supports hypothesis asymmetry. These provide evidence, suggesting coupled serving together instantiate new states by flexibly modulating interacting other control processing networks.

Language: Английский

Citations

7
Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior DOI Creative Commons
Gal Atlan, Noa Matosevich,

Noa Peretz‐Rivlin

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 26, 2024

Abstract The claustrum has been linked to attention and sleep. We hypothesized that this reflects a shared function, determining responsiveness stimuli, which spans the axis of engagement. To test hypothesis, we recorded population dynamics from male mice during both sleep an attentional task (‘ENGAGE’). Heightened activity in neurons projecting anterior cingulate cortex (ACCp) corresponded reduced sensory Similarly, ENGAGE task, heightened ACCp correlated with disengagement behavioral lapses, while low hyper-engagement impulsive errors. Chemogenetic elevation awakenings errors task. Furthermore, employing exploration strategy showed stronger correlation between performance compared exploitation complexity. Our results implicate restricting engagement goal-directed behavior.

Language: Английский

Citations

7
Brain-state-dependent constraints on claustrocortical communication and function DOI Creative Commons
Brian A. Marriott,

D. Alison,

Coline Portet

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 43(1), P. 113620 - 113620

Published: Dec. 29, 2023

Neural activity in the claustrum has been associated with a range of vigilance states, yet patterns and efficacy synaptic communication identified neurons have not thoroughly determined. Here, we show that projecting to retrosplenial cortex are most active during synchronized cortical states such as non-rapid eye movement (NREM) sleep suppressed increased desynchronization arousal, movement, REM sleep. The claustrocortical signaling is NREM diminished due part cholinergic tone. Finally, activation enhances memory consolidation through phase resetting delta waves. Therefore, constrained function effectively cognitive processes consolidation.

Language: Английский

Citations

13
Updating functional brain units: Insights far beyond Luria DOI
Jordi Peña‐Casanova, Gonzalo Sánchez‐Benavides, Jorge Sigg-Alonso

et al.

Cortex, Journal Year: 2024, Volume and Issue: 174, P. 19 - 69

Published: Feb. 29, 2024

Language: Английский

Citations

4
Patent highlights April–May 2024 DOI
Hermann AM Mucke

Pharmaceutical Patent Analyst, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5

Published: Feb. 11, 2025

Language: Английский

Citations

0
Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs DOI Creative Commons
Ekaterina Levichkina, David B. Grayden, Steven Petrou

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 13, 2025

The development of a seizure relies on two factors. One is the existence an overexcitable neuronal network and other trigger that switches normal activity into paroxysmal state. While mechanisms local overexcitation have been focus many studies, process triggering remains poorly understood. We suggest that, apart from known exteroceptive sources reflex epilepsy such as visual, auditory or olfactory signals, there range interoceptive triggers, which are relevant for in Temporal Lobe Epilepsy (TLE). hypothesis proposed here aims to explain prevalence epileptic sleep drowsiness states provide detailed mechanism seizures triggered by signals.

Language: Английский

Citations

0