Food & Function,
Journal Year:
2024,
Volume and Issue:
15(18), P. 9136 - 9148
Published: Jan. 1, 2024
Food
allergy
is
one
of
the
hot
issues
in
field
food
safety,
and
there
have
been
a
lot
concerns
on
how
to
reduce
allergenicity
allergens.
processing
can
change
allergens
matrix.
In
this
study,
ten
IgE
linear
epitopes
major
allergen
tropomyosin
(TM)
Perna
viridis
were
identified
by
bioinformatics
prediction
serological
experiments.
The
transglutaminase-catalyzed
glycosylation
modification
sites
glutamine,
lysine
arginine
highly
represented
TM.
matrix
was
treated
with
glycosylation.
This
reaction
changed
secondary
structure
protein
matrix,
increased
content
β-sheets
decreased
β-turns.
intensity
intrinsic
fluorescence
surface
hydrophobicity
reduced.
IgE-binding
activity
TM
reduced
modifying
seven
amino
acid
residues
six
epitopes.
Transglutaminase-catalyzed
products
allergic
symptoms
mice,
proportion
CD4+IL-4+
Th2
cells,
CD4+IFN-γ+
Th1
cells
Treg
cells.
Mouse
serum
levels
IgG1
antibodies
Therefore,
study
provided
theoretical
basis
for
development
hypoallergenic
products.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(23), P. 9120 - 9134
Published: May 31, 2023
The
mechanism
by
which
thermal/pressure
processing
influences
the
allergenicity
of
shrimp
(Penaeus
vannamei)
was
explored
anaphylaxis
in
mice,
protein
structure,
gastrointestinal
digestion,
and
linear
epitopes.
Roasting
induced
unfolding
may
reduce
allergenicity,
but
it
made
more
epitopes
to
be
exposed,
causing
mice
exhibit
similar
systemic
as
fed
with
raw
(p
>
0.05).
However,
roasted
+
reverse-pressure-sterilized
can
significantly
specific
antibodies,
mast
cell
degranulation,
vascular
permeability,
histopathological
morphology
compared
<
0.05)
because
reverse-pressure
sterilization
causes
aggregate,
hiding
heat/digested
stable
arginine
kinase
(Glu59-Ser63,
Asn112-Lys118,
Leu131-Phe136,
Ser158-Glu162)
sarcoplasmic
calcium-binding
(Asn57-Phe67,
Ser159-Cys165,
Glu126-Ala130)
inside
a
3D
while
digestion
destroy
immunodominant,
minor
exposed
roasting.
Meanwhile,
low
binding
frequency
IgE
troponin
C
also
responsible
for
maintaining
hypoallergenicity
shrimp.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(22), P. 4823 - 4823
Published: Nov. 17, 2023
In
light
of
the
constantly
increasing
prevalence
allergic
diseases,
changes
in
dietary
patterns
have
been
suggested
as
a
plausible
environmental
explanation
for
development
and
progression
these
diseases.
Nowadays,
much
attention
has
paid
to
interventions
using
natural
substances
with
anti-allergy
activities.
this
respect,
polyphenols
studied
extensively
one
most
prominent
bioactive
compounds
well-documented
anti-inflammatory,
antioxidant,
immunomodulatory
properties.
This
review
aims
discuss
mechanisms
underlying
potential
anti-allergic
actions
related
their
ability
reduce
protein
allergenicity,
regulate
immune
response,
gut
microbiome
modification;
however,
issues
need
be
elucidated
detail.
paper
reviews
current
evidence
from
experimental
clinical
studies
confirming
that
various
such
quercetin,
curcumin,
resveratrol,
catechins,
many
others
could
attenuate
inflammation,
alleviate
symptoms
food
allergy,
asthma,
rhinitis,
prevent
response.
Conclusively,
are
endowed
great
therefore
used
either
preventive
approaches
or
therapeutic
relation
Limitations
studying
widespread
use
well
future
research
directions
also
discussed.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(26), P. 14922 - 14940
Published: June 17, 2024
As
a
key
component
of
cell-cultured
fish,
fish
skin
gelatin
(FSG)-based
cell
scaffold
provides
support
structures
for
growth,
proliferation,
and
differentiation.
However,
there
are
potential
allergenicity
risks
contained
in
FSG-based
scaffolds.
In
this
study,
3D
edible
scaffolds
were
prepared
by
phase
separation
method
showed
contact
angle
less
than
90°,
which
indicated
that
the
favorable
adhesion.
Besides,
swelling
ratio
was
greater
200%,
implying
great
to
growth.
The
sequence
homology
analysis
FSG
prone
cross-reaction
with
collagen
analogues.
Additionally,
food
allergic
model
constructed
represented
mice
gavaged
cod
exhibited
higher
levels
specific
antibodies,
mast
degranulation,
vascular
permeability,
intestinal
barrier
impairment
those
pangasius
tilapias
FSG.
Its
might
be
attributed
number
digestion-resistant
linear
epitopes.
Moreover,
hydrolysis
degree
linked
exposure
epitopes
promote
combination
IgE,
also
responsible
maintaining
This
study
clarifies
allergenic
further
will
focus
on
reduction
