International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138549 - 138549
Published: Dec. 9, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101502 - 101502
Published: Jan. 19, 2025
DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These facilitate the formation of spatial structures through bulk hydrogel fabricating, microsphere formatting, 3D printing. Furthermore, microenvironment can be finely tuned by leveraging degradation products, nanostructure, targeting, delivery capabilities inherent materials. In this review, we underscore advantages hydrogels, detailing composition, gelation techniques, structure optimization. We then delineate three critical elements in promotion using hydrogels: (i) osteogenesis driven phosphate ions, plasmids, oligodeoxynucleotides (ODNs) that enhance mineralization promote gene protein expression; (ii) vascularization facilitated tetrahedral DNA nanostructures (TDNs) aptamers, which boosts expression targeted release; (iii) immunomodulation achieved loaded factors, TDNs, bound ions stimulate macrophage polarization exhibit antibacterial properties. With these properties, used construct organoids, providing an innovative tool disease modeling therapeutic applications tissue engineering. Finally, discuss current challenges future prospects, emphasizing potential impacts regenerative medicine.
Language: Английский
Citations
3
Advanced Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Abstract Deoxyribonucleic acid (DNA) nanotechnology has brought an unparalleled set of possibilities for self‐assembled structures emerging as independent branch synthetic biology. The field science uses the molecular properties DNA to build nanoparticles and nanodevices that have potential bring breakthroughs in medical science. On one hand, their biocompatibility, precision, ease, programmability make them ideal choice drug delivery healthcare. other, lack proper biodistribution profiles, stability inside system, enzymatic cleavage, immune recognition, translational barriers are some hurdles it faces. Many recent technological advancements progress tackle these challenges, while already been used. These tools technologies need be understood studied successful transition intelligent nanostructures (DNs) healthcare applications. This review thus, highlights challenges being faced by DNs Additionally, provides overview trends using devices disease detection remission finally talks about future scope opportunities effective from bench bedside.
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Abstract DNA hydrogels have emerged as promising materials in tissue engineering due to their biocompatibility, programmability, and responsiveness stimuli. Synthesized through physical chemical crosslinking, these can be categorized into functionalized types, such those based on aptamers, stimuli‐responsive types that react pH, temperature, light. This review highlights applications engineering, including drug delivery, cell culture, biosensing, gene editing. encapsulate therapeutic agents, support growth, respond dynamically environmental changes, making them ideal for engineering. A comprehensive bibliometric analysis is included, identifying key research trends emerging areas of interest hydrogel design, synthesis, biomedical applications. The provides a deeper understanding the field's development future directions. Challenges mechanical strength, stability, biosafety persist, but integration AI design shows promise advancing functionality clinical
Language: Английский
Citations
0
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: May 8, 2025
Abstract Sequence‐programmable DNA building blocks offer high degree of freedom in designing arbitrarily complex networks tunable viscoelastic properties. Yet, the deployment DNA‐based functional materials remains limited due to insufficient control over emerging structures and their mechanics. In an ongoing effort place structure‐property relations stimuli‐responsive on a firm foundation, here systematic rheological study self‐assembling is presented, comprised short nanomotifs, namely trivalent nanostars bivalent linkers, where latter differ composition single base‐pair level. Notably, we found through combining conventional bulk rheology with diffusing wave spectroscopy (DWS‐based) passive microrheology relationship between melting temperature hydrogel its sequence composition. By providing use case, demonstrated how determination such empirical could impact areas biosensing mechanical computing, system state target identification are key.
Language: Английский
Citations
0
Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 156, P. 110331 - 110331
Published: June 18, 2024
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138549 - 138549
Published: Dec. 9, 2024
Language: Английский
Citations
0