Molecular Ecology,
Journal Year:
2017,
Volume and Issue:
26(8), P. 2257 - 2275
Published: Jan. 31, 2017
Increasing
awareness
of
spatial
and
temporal
variation
in
ocean
pH
suggests
some
marine
populations
may
be
adapted
to
local
regimes
will
therefore
respond
differently
present-day
long-term
acidification.
In
the
Northeast
Pacific
Ocean,
differences
strength
coastal
upwelling
cause
latitudinal
prevailing
that
are
hypothesized
promote
adaptation
unequal
tolerance
among
resident
populations.
this
study,
responses
experimental
seawater
acidification
were
compared
embryos
larvae
from
six
purple
sea
urchins
(Strongylocentrotus
purpuratus)
inhabiting
areas
differ
their
frequency
low
exposure
prior
research
locally
pH.
Transcriptomic
analyses
demonstrate
urchin
most
frequently
exposed
responded
by
expressing
genes
within
major
ATP-producing
pathways
at
greater
levels
than
encountering
less
often.
Multiple
tricarboxylic
acid
cycle,
electron
transport
chain
fatty
beta
oxidation
upregulated
experiencing
conditions
frequently.
These
same
metabolic
significantly
over-represented
both
expressed
a
population-specific
manner
putatively
under
selection
enhance
tolerance.
Collectively,
these
data
suggest
natural
is
acting
on
gene
networks
redirect
ATP
toward
maintaining
acid-base
homeostasis
As
trade-off,
more
tolerant
have
energy
put
towards
other
aspects
fitness
additional
change.
Reports on Progress in Physics,
Journal Year:
2014,
Volume and Issue:
77(2), P. 026601 - 026601
Published: Jan. 20, 2014
Noise
permeates
biology
on
all
levels,
from
the
most
basic
molecular,
sub-cellular
processes
to
dynamics
of
tissues,
organs,
organisms
and
populations.
The
functional
roles
noise
in
biological
can
vary
greatly.
Along
with
standard,
entropy-increasing
effects
producing
random
mutations,
diversifying
phenotypes
isogenic
populations,
limiting
information
capacity
signaling
relays,
it
occasionally
plays
more
surprising
constructive
by
accelerating
pace
evolution,
providing
selective
advantage
dynamic
environments,
enhancing
intracellular
transport
biomolecules
increasing
pathways.
This
short
review
covers
recent
progress
understanding
mechanisms
fluctuations
systems
different
scales
approaches
their
mathematical
modeling.
Cell Reports,
Journal Year:
2015,
Volume and Issue:
13(12), P. 2653 - 2662
Published: Dec. 1, 2015
mRNA
is
thought
to
predominantly
reside
in
the
cytoplasm,
where
it
translated
and
eventually
degraded.
Although
nuclear
retention
of
has
a
regulatory
potential,
considered
extremely
rare
mammals.
Here,
explore
extent
metabolic
tissues,
we
combine
deep
sequencing
cytoplasmic
RNA
fractions
with
single-molecule
transcript
imaging
mouse
beta
cells,
liver,
gut.
We
identify
wide
range
protein-coding
genes
for
which
levels
spliced
polyadenylated
are
higher
nucleus
than
cytoplasm.
These
include
such
as
transcription
factor
ChREBP,
Nlrp6,
Glucokinase,
Glucagon
receptor.
demonstrate
that
can
efficiently
buffer
from
noise
emanates
transcriptional
bursts.
Our
study
challenges
view
transcripts
cytoplasm
reveals
role
dampening
gene
expression
noise.
Annual Review of Biophysics,
Journal Year:
2013,
Volume and Issue:
42(1), P. 469 - 491
Published: March 25, 2013
The
biochemical
processes
leading
to
the
synthesis
of
new
proteins
are
random,
as
they
typically
involve
a
small
number
diffusing
molecules.
They
lead
fluctuations
in
single
cell
function
time
and
cell-to-cell
variability
protein
abundances.
These
turn
can
phenotypic
heterogeneity
population
genetically
identical
cells.
Phenotypic
may
have
important
consequences
for
development
multicellular
organisms
fitness
bacterial
colonies,
raising
question
how
it
is
regulated.
Here
we
review
experimental
evidence
that
transcriptional
regulation
affects
noise
gene
expression,
discuss
strength
encoded
architecture
promoter
region.
We
models
based
on
specific
molecular
mechanisms
make
experimentally
testable
predictions
changes
reflected
expression
noise.
Frontiers in Plant Science,
Journal Year:
2013,
Volume and Issue:
4
Published: Jan. 1, 2013
The
current
status
of
lignocellulosic
biomass
as
an
invaluable
resource
in
industry,
agriculture
and
health
has
spurred
increased
interest
understanding
the
transcriptional
regulation
secondary
cell
wall
(SCW)
biosynthesis.
last
decade
research
revealed
extensive
network
NAC,
MYB
other
families
transcription
factors
regulating
Arabidopsis
SCW
biosynthesis,
numerous
studies
have
explored
SCW-related
dicots
monocots.
Whilst
general
structure
been
a
topic
several
reviews,
they
not
comprehensively
represented
detailed
protein-DNA
protein-protein
interactions
described
literature,
dynamics
functionality
yet
achieved
for
formation.
Furthermore
methodologies
employed
received
much
attention,
especially
case
non-model
organisms.
In
this
review,
we
reconstructed
most
exhaustive
literature-based
representations
to
date
Arabidopsis.
We
include
manipulable
Cytoscape
representation
aid
future
studies,
along
with
list
supporting
literature
each
documented
interaction.
Amongst
topics,
discuss
various
components
network,
its
evolutionary
conservation
plants,
putative
modules
dynamic
mechanisms
that
may
influence
function,
approaches
inference.
Future
should
aim
better
understand
function
response
perturbations,
whilst
development
application
genome-wide
such
ChIP-seq
systems
genetics
are
progress
study
