An Emerging Class of Long Non-coding RNA With Oncogenic Role Arises From the snoRNA Host Genes

Frontiers in Oncology, Journal Year: 2020, Volume and Issue: 10

Published: April 7, 2020

The small nucleolar RNA host geness (SNHG) consist of a group long non-coding RNAs, which are reported in many studies as being overexpressed various cancers. With very few exceptions, the SNHGs (SNHG1, SNHG3, SNHG5, SNHG6, SNHG7, SNHG12, SNHG15, SNHG16, SNHG20) recognized inducing increased proliferation, cell cycle progression, invasion and metastasis cancer cells makes this class transcripts viable biomarker for development aggressiveness. Through our literature research , we also found silencing through interfering RNAs or short hairpin is effective both vitro vivo experiments by lowering solid cancers knock down SNHG new therapeutic option should be investigated more future.

Language: Английский

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Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells

Cell Reports, Journal Year: 2018, Volume and Issue: 25(3), P. 715 - 725.e4

Published: Oct. 1, 2018

The regulation and functional roles of secreted coding long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), circular RNAs. Here, we comprehensively identify diverse classes CRC in EVs demonstrate differential export specific Distinct RNAs, including antisense transcripts derived from pseudogenes, enriched compared to cellular profiles. detected strong enrichment Rab13 delivery mRNA recipient cells. To assay transfer lncRNAs, implemented a CRISPR/Cas9-based RNA-tracking system monitor show gRNAs signals can be transferred donor Our data support the existence mechanisms selectively RNA.

Language: Английский

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The Function of Non-Coding RNAs in Lung Cancer Tumorigenesis

Cancers, Journal Year: 2019, Volume and Issue: 11(5), P. 605 - 605

Published: April 30, 2019

Lung cancer is the most prevalent and deadliest worldwide. A significant part of lung studies dedicated to expression alterations non-coding RNAs. The RNAs are transcripts that cannot be translated into proteins. While study microRNAs siRNAs in received a lot attention over last decade, highly efficient therapeutic option or diagnostic methods based on still lacking. Because this, it utmost importance direct future research towards analyzing other RNA types for which currently available data indicates essential at modulating tumorigenesis. Through our review this subject, we identify following as tumor suppressors: ts-46, ts-47, ts-101, ts-53, ts-3676, ts-4521 (tRNA fragments), SNORD116-26, HBII-420, SNORD15A, SNORA42 (snoRNAs), piRNA-like-163, piR-35127, piR-46545 (piRNAs), CHIAP2, LOC100420907, RPL13AP17 (pseudogenes), uc.454 (T-UCR). We also found with tumor-promoting function: tRF-Leu-CAG, tRNA-Leu, tRNA-Val circ-RAD23B, circRNA 100146, circPVT1, circFGFR3, circ_0004015, circPUM1, circFLI1, circABCB10, circHIPK3 (circRNAs), SNORA42, SNORA3, SNORD46, SNORA21, SNORD28, SNORA47, SNORD66, SNORA68, SNORA78 piR-65, piR-34871, piR-52200, piR651 hY4 5’ fragments (YRNAs), FAM83A-AS1, WRAP53, NKX2-1-AS1 (NATs), DUXAP8, SFTA1P (pseudogene transcripts), uc.338, uc.339 (T-UCRs), hTERC.

Language: Английский

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NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

Non-coding RNA Research, Journal Year: 2018, Volume and Issue: 3(4), P. 243 - 252

Published: Nov. 15, 2018

Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative heterogeneous in both their clinical features and underlying physiology, they all characterised by progressive loss specific neuronal populations. Recent experimental evidence suggests that long non-coding RNAs (lncRNAs) play important roles CNS health disease. Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) is an abundant, ubiquitously expressed lncRNA, which forms a scaffold for RNA granule nucleus, or nuclear body, paraspeckle. Paraspeckles act as molecular hubs cellular processes commonly affected neurodegeneration. Transcriptomic analyses diseased human tissue have revealed altered NEAT1 levels major disorders well some disease models. it clear changes expression (and cases, paraspeckle assembly) accompany damage, our understanding contribution to pathogenesis still rudimentary. In this review, we summarised available knowledge on involvement linked neurodegeneration dysregulation type disease, with special focus amyotrophic lateral sclerosis. The goal review attract attention researchers field paraspeckles.

Language: Английский

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A novel antisense long noncoding RNA,TWISTED LEAF, maintains leaf blade flattening by regulating its associated sense R2R3‐MYB gene in rice

New Phytologist, Journal Year: 2018, Volume and Issue: 218(2), P. 774 - 788

Published: Feb. 7, 2018

Summary Natural antisense long noncoding RNA s (lnc s) are widespread in many organisms. However, their biological functions remain largely unknown, particularly plants. We report the identification and characterization of an endogenous lnc , TWISTED LEAF ( TL ), which is transcribed from opposite strand R2R3 MYB transcription factor gene locus, Os 60 rice Oryza sativa ). were found to be coexpressed different tissues, expression level was higher than that . Downregulation by interference i) overexpression resulted twisted leaf blades transgenic rice. The significantly increased ‐ i This suggests may play a cis ‐regulatory role on morphological development. also determined suppressed sense mediating chromatin modifications. further discovered C2H2 factor, ZFP 7, binding partner involved Taken together, these findings reveal ‐natural plays critical maintaining blade flattening Our study uncovers regulatory mechanism plant

Language: Английский

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