Strong mitonuclear discordance in the phylogeny of Neodermata and evolutionary rates of Polyopisthocotylea

International Journal for Parasitology, Journal Year: 2024, Volume and Issue: 54(5), P. 213 - 223

Published: Jan. 5, 2024

Language: Английский

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Genomic richness enables worldwide invasive success

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Abstract Biological invasions are a major threat to biodiversity. Therefore, monitoring genomic features of invasive species is crucial understand their population structure and adaptive processes. However, resources scarce, compromising the study success. Here, we present reference genome Styela plicata , one most widespread marine species, combined with data 24 individuals from 6 populations distributed worldwide. We characterized large inversions in four chromosomes, accounting for ~ 15% size. These polymorphic through species’ distribution area, enriched genes enhancing fitness estuary harbor environments. Nonetheless, mask detection S. structure. When these structural variants removed, successfully identify main oceanographic barriers accurately characterize differentiation between within ocean basins. Several located chromosome 3 showcased as drivers biogeographic regions. Moreover, recover three mitogenomic clades, involving rearrangements leading cyto-nuclear coevolution likely involved mitochondrion during cell division. Our results suggest that contribute structuring adaptation processes, potentially success when colonizing new habitats.

Language: Английский

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Genomic Signatures of Mitonuclear Coevolution in Mammals

Molecular Biology and Evolution, Journal Year: 2022, Volume and Issue: 39(11)

Published: Oct. 27, 2022

Abstract Mitochondrial (mt) and nuclear-encoded proteins are integrated in aerobic respiration, requiring co-functionality among gene products from fundamentally different genomes. Different evolutionary rates, inheritance mechanisms, selection pressures set the stage for incompatibilities between interacting of two The mitonuclear coevolution hypothesis posits that may be avoided if evolution one genome selects complementary changes genes encoded by other genome. Nuclear compensation, which deleterious mtDNA offset compensatory nuclear changes, is often invoked as primary mechanism coevolution. Yet, direct evidence supporting compensation rare. Here, we used data 58 mammalian species representing eight orders to show strong correlations rates mt mt-targeted (N-mt) proteins, but not non-mt-targeted providing support across mammals. N-mt with interactions also showed strongest correlations. Although most had elevated dN/dS ratios compared (as predicted under compensation), sites close contact were overrepresented signs positive noncontact (contrary predictions compensation). Furthermore, temporal patterns amino acid substitutions did even positively selected, functionally important residues contacts. Overall, our results strongly ∼170 million years fail major mode

Language: Английский

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Cytonuclear Interactions and Subgenome Dominance Shape the Evolution of Organelle-Targeted Genes in the Brassica Triangle of U

Molecular Biology and Evolution, Journal Year: 2024, Volume and Issue: 41(3)

Published: Feb. 23, 2024

Abstract The interaction and coevolution between nuclear cytoplasmic genomes are one of the fundamental hallmarks eukaryotic genome evolution and, 2 billion yr later, still major contributors to formation new species. Although many studies have investigated role cytonuclear interactions following allopolyploidization, relative magnitude effect subgenome dominance versus on remains unclear. Brassica triangle U features 3 diploid species that together formed separate allotetraploid similar evolutionary timescales, providing an ideal system for understanding contribution donor hybrid polyploid. Here, we pattern organelle-targeted genes in carinata (BBCC) varieties juncea (AABB) at whole-genome level, with particular focus enzyme complexes. We found partial evidence plastid-targeted experience selection match plastid genomes, but no obvious corresponding signal mitochondria-targeted from these separately allopolyploids. Interestingly, acting always reduced retention rate encoded by B subgenome, regardless whether nigra (BB) was contributed paternal or maternal progenitor. More broadly, this study illustrates distinct selective pressures experienced plastid- genes, despite a shared inheritance natural history. Our also highlights important allopolyploid evolution, even whose function depends inherited molecules.

Language: Английский

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Mitonuclear interactions impact aerobic metabolism in hybrids and may explain mitonuclear discordance in young, naturally hybridizing bird lineages

Molecular Ecology, Journal Year: 2024, Volume and Issue: 33(12)

Published: May 10, 2024

Abstract Understanding genetic incompatibilities and introgression between incipient species are major goals in evolutionary biology. Mitochondrial genes evolve rapidly exist dense gene networks with coevolved nuclear genes, suggesting that mitochondrial respiration may be particularly susceptible to disruption hybrid organisms. Mitonuclear interactions have been demonstrated contribute dysfunction deeply divergent taxa crossed the laboratory, but there few empirical examples of mitonuclear younger lineages naturally hybridize. Here, we use controlled crosses high‐resolution respirometry provide first experimental evidence a bird inter‐lineage impact aerobic metabolism. Specifically, capacity two mitodiscordant backcrosses (with mismatched combinations) differs from one another, although they do not differ significantly parental groups or mitoconcordant as would expect disruptions. In wild zone these subspecies, cline centre is shifted west centre, which consistent direction our results. Our results therefore demonstrate asymmetric cellular help explain geographic discordance genomes observed wild.

Language: Английский

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Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural Drosophila populations

Evolution Letters, Journal Year: 2024, Volume and Issue: 8(6), P. 916 - 926

Published: Aug. 9, 2024

Abstract Mitochondrial function depends on the effective interactions between proteins and RNA encoded by mitochondrial nuclear genomes. Evidence suggests that both genomes respond to thermal selection promote adaptation. However, contribution of their epistatic life history phenotypes in wild remains elusive. We investigated evolutionary implications mitonuclear a real-world scenario sees populations adapted different environments, altering geographical distribution while experiencing flow admixture. created Drosophila melanogaster panel with replicate native from ends Australian east-coast cline, into which we substituted mtDNA haplotypes were either predominant or rare at each cline-end, thus creating putatively matched mismatched populations. Our results suggest mismatching may impact phenotype, harboring rarer haplotype suffering trade-off aerobic capacity key fitness aspects such as reproduction, growth, survival. discuss significance modulators context future adaptation population persistence.

Language: Английский

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Current progress with mammalian models of mitochondrialDNAdisease

Journal of Inherited Metabolic Disease, Journal Year: 2020, Volume and Issue: 44(2), P. 325 - 342

Published: Oct. 25, 2020

Abstract Mitochondrial disorders make up a large class of heritable diseases that cause broad array different human pathologies. They can affect many organ systems, or display very specific tissue presentation, and lead to illness either in childhood later life. While the over 1200 genes encoded nuclear DNA play an important role mitochondrial disease, it has been known for 30 years mutations mitochondria's own small, multicopy chromosome (mtDNA) diseases. Unfortunately, animal mtDNA resisted transgenic directed genome editing technologies until quite recently. As such, models aid our understanding these diseases, explore preclinical therapeutic research have rare. This review will discuss unusual properties mitochondria hindered generation models. It also existing mammalian describe methods employed their generation, recent advances targeting DNA‐manipulating enzymes how may be generate new

Language: Английский

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A Lethal Genetic Incompatibility between Naturally Hybridizing Species in Mitochondrial Complex I

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: July 14, 2021

Abstract The evolution of reproductive barriers is the first step in formation new species and can help us understand diversification life on Earth. These often take form “hybrid incompatibilities,” where alleles derived from two different no longer interact properly hybrids. Theory predicts that hybrid incompatibilities may be more likely to arise at rapidly evolving genes involving multiple should common, but there has been sparse empirical data evaluate these predictions. Here, we describe a mitonuclear incompatibility three physical contact within respiratory Complex I naturally hybridizing swordtail fish species. Individuals homozygous for specific mismatched protein combinations fail complete embryonic development or die as juveniles, while those heterozygous have reduced function unbalanced representation parental mitochondrial proteome. We find impacts genetic interactions survival are non-additive, highlighting subtle complexity architecture incompatibilities. document evolutionary history involved, showing time an transferred between via hybridization. This work thus provides glimpse into architecture, physiological impacts, origin complex impacting

Language: Английский

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The genomic basis of evolutionary differentiation among honey bees

Genome Research, Journal Year: 2021, Volume and Issue: 31(7), P. 1203 - 1215

Published: May 4, 2021

In contrast to the western honey bee, Apis mellifera, other bee species have been largely neglected despite their importance and diversity. The genetic basis of evolutionary diversification bees remains unknown. Here, we provide a genome-wide comparison three species, each representing one subgenera bees, namely dwarf (Apis florea), giant (A. dorsata), cavity-nesting mellifera) with bumblebees as an outgroup. Our analyses resolve phylogeny diverging first. We find that evolution increased eusocial complexity in proceeds via increases gene regulation, which is agreement previous studies. However, this process seems be related pathways than transcriptional control. Positive selection patterns across reveal trade-off between maintaining genome stability generating diversity, rapidly evolving piRNA pathway leading genomes depleted transposable elements, DNA repair associated high recombination rates all species. Diversification within accompanied by positive several genes whose putative functions present candidate mechanisms for lineage-specific adaptations, such migration, immunity, nesting behavior.

Language: Английский

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Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 30, 2022

Abstract Human mitochondrial gene expression relies on the specific recognition and aminoacylation of tRNAs (mtRNAs) by nuclear-encoded aminoacyl-tRNA synthetases (mt-aaRSs). Despite their essential role in cellular energy homeostasis, strong mutation pressure genetic drift have led to an unparalleled sequence erosion animal mtRNAs. The structural functional consequences this are not understood. Here, we present cryo-EM structures human seryl-tRNA synthetase (mSerRS) complex with mtRNA Ser(GCU) . These reveal a unique mechanism substrate aminoacylation. is highly degenerated, having lost entire D-arm, tertiary core, stable L-shaped fold that define canonical tRNAs. Instead, evolved innovations, including radically altered T-arm topology serves as critical identity determinant unusual shape-selective readout mSerRS. Our results provide molecular framework understand principles mito-nuclear co-evolution specialized mechanisms tRNA mammalian expression.

Language: Английский

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