Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102334 - 102334
Published: June 11, 2024
Language: Английский
Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(12), P. 703 - 722
Published: Oct. 17, 2022
Language: Английский
Citations
154
The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503
Published: Aug. 29, 2023
•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.
Language: Английский
Citations
65
Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(4), P. 274 - 287
Published: March 16, 2024
Language: Английский
Citations
20
Seminars in Immunology, Journal Year: 2023, Volume and Issue: 69, P. 101805 - 101805
Published: July 8, 2023
Language: Английский
Citations
31
Biomaterials Science, Journal Year: 2022, Volume and Issue: 11(2), P. 432 - 444
Published: Dec. 6, 2022
The barrier function of host cells enables intracellular bacteria to evade the lethality immune system and antibiotics, thereby causing chronic recurrent infections that seriously threaten human health. Currently, main clinical strategy for treatment bacterial involves use long-term high-dose antibiotics. However, insufficient delivery antibiotics along with various resistance mechanisms not only weakens efficacy current therapies but also causes serious adverse drug reactions, further increasing disease economic burden. Improving efficiency, accumulation, action time remains most economical effective way treat infections. rapid development nanotechnology provides a efficiently deliver against into cells. In this review, we summarize types common pathogens, difficulties faced by in infections, research progress several representative nanocarriers have emerged recent years. This review is expected provide reference elucidating transport mechanism nanocarrier-drug complexes, designing safer more establishing new strategies infection.
Language: Английский
Citations
36
British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 24, 2023
For decades, the major focus of redox biology has been oxygen, most abundant element on Earth. Molecular oxygen functions as final electron acceptor in mitochondrial respiratory chain, contributing to energy production aerobic organisms. In addition, oxygen-derived reactive species including hydrogen peroxide and nitrogen free radicals, such superoxide, hydroxyl radical nitric oxide radical, undergo a complicated sequence transfer reactions with other biomolecules, which lead their modified physiological diverse biological pathophysiological consequences (e.g. oxidative stress). What is now evident that accounts for only small number organisms knowledge still quite limited. This article reviews new aspects governed by redox-active sulfur-containing molecules-supersulfides. We define term 'supersulfides' sulfur catenated atoms. Supersulfides were determined be all organisms, but properties have remained largely unexplored. fact, unique chemical supersulfides permit them readily ionized or radicalized, thereby allowing actively participate antioxidant responses cells. Accumulating evidence demonstrated are indispensable fundamental processes production, nucleic acid metabolism, protein translation others. Moreover, manipulation supersulfide levels was beneficial pathogenesis various diseases. Thus, opened era disease control includes potential applications clinical diagnosis, prevention therapeutics
Language: Английский
Citations
21
World Journal of Gastrointestinal Oncology, Journal Year: 2023, Volume and Issue: 15(5), P. 713 - 730
Published: May 11, 2023
Pancreatic cancer is a high mortality malignancy with almost equal and morbidity rates. Both normal tumour tissues of the pancreas were previously considered sterile. In recent years, development technologies for high-throughput sequencing, variety studies have revealed that pancreatic contain small amounts bacteria fungi. The intratumour microbiome being as an influential contributor to carcinogenesis. has been identified crucial factor progression, diagnosis, treatment, chemotherapy resistance, immune response. A better understanding biology contributes establishment early screening treatment strategies. This review focuses on possible origins in cancer, localization, interaction microenvironment, strategies improving outcome treatment. Thus, this offers new perspectives prognosis cancer.
Language: Английский
Citations
16
EMBO Reports, Journal Year: 2024, Volume and Issue: 25(11), P. 4979 - 5005
Published: Oct. 7, 2024
Language: Английский
Citations
5
Macromolecular Bioscience, Journal Year: 2022, Volume and Issue: 23(1)
Published: Oct. 3, 2022
Abstract The intracellular survival of pathogenic bacteria requires a range strategies and virulence factors. These infections are significant clinical challenge, wherein treatment frequently fails because poor antibiotic penetration, stability, retention in host cells. Drug delivery systems (DDSs) promising tools to overcome these shortcomings enhance the efficacy therapy. In this review, classification mechanisms bacterial persistence elaborated. Furthermore, systematic design applied DDSs eliminate also described, used for internalization, activation, targeting, immune enhancement highlighted. Finally, overview provides guidance constructing functionalized effectively bacteria.
Language: Английский
Citations
20
mSystems, Journal Year: 2023, Volume and Issue: 8(5)
Published: Aug. 18, 2023
Salmonella infection is a significant threat to global public health, and the increasing prevalence of antibiotic resistance exacerbates situation. Therefore, finding new effective ways combat this pathogen essential. Phages are natural predators bacteria can be used as an alternative antibiotics kill specific bacteria, including drug-resistant strains. One limitation using phages antimicrobial agents their low cellular uptake, which limits effectiveness against intracellular bacterial infections. enhance phage uptake crucial. Our study provides straightforward strategy for displaying cell-penetrating peptides on non-model phages, offering promising novel therapeutic approach treating bacteria. This has potential address challenge improve health outcomes.
Language: Английский
Citations
13