Lactiplantibacillus plantarum FRT4 attenuates high-energy low-protein diet-induced fatty liver hemorrhage syndrome in laying hens through regulating gut-liver axis

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 21, 2024

Abstract Background Fatty liver hemorrhage syndrome (FLHS) becomes one of the most major factors resulting in laying hen death for caged egg production. This study aimed to investigate therapeutic effects Lactiplantibacillus plantarum ( Lp. ) FRT4 on FLHS model with a focus lipid metabolism, and gut microbiota. Results The hens was established by feeding high-energy low-protein (HELP) diet, treatment groups were fed HELP diet supplemented differential proportions FRT4. results indicated that increased rate, reduced accumulation regulating metabolism (lipid synthesis transport) improving microbiota composition. Moreover, regulated glycerophospholipid metabolism. Meanwhile, “gut-liver” axis analysis showed there correlation between metabolites. Conclusions improved performance alleviated diet-induced through axis. Our findings reveal could be underlying mechanism anti-FLHS effect future use as an excellent additive prevention mitigation hens.

Language: Английский

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Microbiome-Metabolome Analysis Insight into the Effects of the Extract of Phyllanthus emblica L. on High-Fat Diet-Induced Hyperlipidemia

Metabolites, Journal Year: 2024, Volume and Issue: 14(5), P. 257 - 257

Published: April 29, 2024

The fruit of Phyllanthus emblica L. (FEPE) has a long history use in Asian folk medicine. main bioactive compounds FEPE are polyphenols, known for their potent antioxidant, anti-inflammatory, and hypolipidemic activities. present study aimed to investigate the intervention effect (100 200 mg/kg) on hyperlipidemia 8 weeks preliminarily explored potential mechanism by microbiome-metabolome analysis. results showed that high-dose (200 effectively alleviated dyslipidaemic symptoms body weight gain hyperlipidemic mice induced high-fat diet (HFD). Microbiome analysis altered structure intestinal microbiota, which included an increase specific probiotics (such as Akkermansia, Anaerovorax, Bacteroides) decrease harmful bacteria (including A2, Acetitomaculum, Candidatus_Arthromitus, Lachnospiraceae_NK4A136_group, Lachnospiraceae_NK4B4_group, Rikenella, Streptococcus), well reduction level short-chain fatty acids (SCFAs). In addition, significant changes hepatic metabolome were observed, eight key metabolites associated with betaine metabolism, lysine degradation, methionine acid metabolism pathways primarily filtered. correlated identified several “microbiota-metabolite” axes treatment extract. conclusion, is expected provide basis treating from perspective microbiome-liver axis.

Language: Английский

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The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis?

Progress in Lipid Research, Journal Year: 2022, Volume and Issue: 89, P. 101209 - 101209

Published: Dec. 5, 2022

Language: Английский

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Revealing the Potential Impacts of Nutraceuticals Formulated with Freeze-Dried Jabuticaba Peel and Limosilactobacillus fermentum Strains Candidates for Probiotic Use on Human Intestinal Microbiota

Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 16(5), P. 1773 - 1789

Published: Aug. 10, 2023

Language: Английский

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An insight into the critical role of gut microbiota in triggering the phthalate-induced toxicity and its mitigation using probiotics

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 904, P. 166889 - 166889

Published: Sept. 6, 2023

Language: Английский

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