Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 11, 2024
Human
skin
acts
as
a
protective
barrier
between
the
body
and
external
environment.
Skin
microbiome
intercellular
lipids
in
stratum
corneum
(SC)
are
essential
for
maintaining
function.
However,
interplay
bacteria
is
not
fully
understood.
In
this
study,
we
characterized
SC
lipid
profiles
from
forearm
face
cohort
of
57
healthy
participants.
16S
rRNA
gene
sequencing
showed
microbial
composition
significantly
different
locations
genders.
Female
samples
have
highest
diversity.
The
relative
abundance
Staphylococcus
hominis,
Micrococcus
luteus,
Corynebacterium
tuberculostearicum,
Finegoldia
magna,
Moraxellaceae
sp.
higher
than
face.
predictive
functional
analysis
by
Phylogenetic
Investigation
Communities
Reconstruction
Unobserved
States
(PICRUSt2)
ANCOM-BC
bacterial
metabolic
pathway
or
genders,
identified
271
differential
pathways,
including
arginine
polyamine
biosynthesis,
chorismate
biosynthesis
which
more
abundant
female
forearm,
sulfur
oxidation
pathway,
male
differ
well.
Total
free
fatty
acids
(FFA),
cholesterol
sulfate
sphingosine
Dihydro-/6-hydroxy/phyto-ceramides
forearm.
correlation
revealed
novel
lipids.
Shannon
entropy
S.
hominis
negatively
correlated
with
FFA,
sphingosine;
while
positively
dihydro-/6-hydroxy/phyto-ceramides.
pathways
involved
amino
metabolism,
carbohydrates
degradation,
aromatic
compounds
metabolism
acid
degradation
dihydro-/6-hydroxy/phyto-ceramides
sphingosine.
This
study
provides
insights
on
potential
Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
260, P. 108681 - 108681
Published: June 17, 2024
Our
skin
protects
us
from
external
threats
including
ultraviolet
radiation,
pathogens
and
chemicals,
prevents
excessive
trans-epidermal
water
loss.
These
varied
activities
are
reliant
on
a
vast
array
of
lipids,
many
which
unique
to
skin,
that
support
physical,
microbiological
immunological
barriers.
The
cutaneous
physical
barrier
is
dependent
specific
lipid
matrix
surrounds
terminally-differentiated
keratinocytes
in
the
stratum
corneum.
Sebum-
keratinocyte-derived
lipids
cover
skin's
surface
regulate
microbiota.
Meanwhile,
signal
between
resident
infiltrating
immune
cells,
driving
inflammation
its
resolution
response
other
threats.
Lipids
particular
importance
include
ceramides,
crucial
for
corneum
formation
therefore
functionality,
fatty
acids,
contribute
acidic
pH
microbiota,
as
well
matrix,
bioactive
metabolites
these
involved
cell
signalling,
inflammation,
numerous
processes.
diverse
complex
maintain
homeostasis
healthy
implicated
diseases,
unrelated
systemic
conditions
with
manifestations,
processes
such
ageing.
also
gut-skin
axis,
signalling
two
sites.
Therefore,
provide
valuable
resource
exploration
processes,
local
disease
development
progression,
accessible
biomarker
discovery
disease,
an
opportunity
fully
understand
relationship
host
Investigation
could
diagnostic
prognostic
biomarkers,
help
identify
new
targets
interventions.
Development
improvement
existing
vitro
silico
approaches
explore
lipidome,
advances
lipidomics
technologies,
will
facilitate
ongoing
progress
research.
Journal of Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
135(8)
Published: Aug. 1, 2024
As
our
understanding
of
dermatological
conditions
advances,
it
becomes
increasingly
evident
that
traditional
pharmaceutical
interventions
are
not
universally
effective.
The
intricate
balance
the
skin
microbiota
plays
a
pivotal
role
in
development
various
conditions,
prompting
growing
interest
probiotics,
or
live
biotherapeutic
products
(LBPs),
as
potential
remedies.
Specifically,
topical
application
LBPs
to
modulate
bacterial
populations
on
has
emerged
promising
approach
alleviate
symptoms
associated
with
common
conditions.
This
review
considers
and
their
addressing
wide
spectrum
particular
emphasis
three
key
areas:
acne,
atopic
dermatitis,
wound
healing.
Within
this
context,
critical
strain
selection
is
presented
factor
effectively
managing
these
concerns.
Additionally,
formulation
challenges
probiotic
viability
proposes
personalised
facilitate
compatibility
skin's
unique
microenvironment.
analysis
offers
valuable
insights
into
applications,
underlining
promise
reshaping
landscape
treatments
while
acknowledging
hurdles
must
be
overcome
unlock
full
potential.
Journal of Investigative Dermatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
The
skin
acts
as
a
barrier
against
external
threats
and
plays
an
important
role
in
tissue
repair.
Skin
cells,
including
keratinocytes,
sense
microbe-associated
molecular
pattern
molecules
released
by
members
of
the
bacterial
microbiome,
cellular
responses
control
central
processes
homeostasis
or
inflammation.
How
combination
amount
different
patterns
modulate
cell
functions
is
not
yet
fully
understood.
Here,
we
review
current
knowledge
cells
to
patterns,
focusing
on
Toll-like
receptor
2
formyl
peptide
2,
two
most
receptors
for
sensing
microbiome.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 948 - 948
Published: April 20, 2025
Trillions
of
microorganisms
play
a
pivotal
role
in
maintaining
health
and
preventing
disease
humans.
Their
presence
influences
daily
life,
habits,
energy
levels,
pathologies.
The
present
narrative
review
synthesized
recent
studies
microbial
diversity
across
organ
systems.
composition
the
microbiota
regulates
intestinal
barrier,
modulates
immune
response,
metabolism,
produces
essential
compounds
such
as
short-chain
fatty
acids
neurotransmitters.
Dysbiosis
is
associated
with
numerous
pathologies,
including
metabolic,
autoimmune,
neurodegenerative,
cardiovascular
diseases.
key
to
physiological
balance
reducing
risk.
Therapeutic
interventions,
probiotics,
prebiotics,
postbiotics,
microbiome
transplantation,
offer
promising
perspectives
restoring
homeostasis
chronic
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 3, 2025
Non-healing
chronic
wounds
with
high
susceptibility
to
infection
represent
a
critical
challenge
in
modern
healthcare.
While
growth
factors
play
pivotal
role
regulating
wound
repair,
their
therapeutic
efficacy
is
compromised
infected
microenvironments.
Current
dressings
inadequately
address
the
dual
demands
of
sustained
bioactive
molecule
delivery
and
robust
antimicrobial
activity.
In
this
study,
we
developed
sodium
alginate
hydrogel
(termed
P-SA/Ins),
which
incorporated
polyhexamethylene
biguanide
(PHMB)
grafting
long-acting
glargine
insulin
loading.
P-SA/Ins
exhibited
favorable
physicochemical
performance,
biocompatibility
antibacterial
against
both
Gram-negative
Gram-positive
pathogens
through
inhibition
bacterial
proliferation
biofilm
formation.
Glargine
was
applied
prolonged
delivery.
treatment
attenuated
S.
aureus
induced
pro-inflammatory
cytokine
cascades
macrophages.
The
evaluation
vivo
using
rat
model
demonstrated
that
significantly
enhanced
healing
optimized
skin
barrier
antimicrobial-mediated
modulation
macrophage
polarization
subsequent
inflammatory
profiling.
Our
findings
demonstrate
promotes
restores
epidermal
integrity,
indicating
its
potential
as
dressing
for
healing,
particularly
cases
risk.
Tissue Barriers,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 31, 2024
The
skin
is
the
largest
organ
of
human
body
and
widely
considered
to
be
first-line
defense
body,
providing
essential
protection
against
mechanical,
physical,
chemical
damage.
Keratinocytes
are
primary
cells
outer
layer
epidermis,
which
acts
as
a
mechanical
permeability
barrier.
epidermis
permanently
renewed
tissue
where
undifferentiated
keratinocytes
located
at
basal
proliferate
migrate
overlying
layers.
Here
we
report
that
some
components
affect
formation
differentiation
stratum
corneum,
most
specialized
epidermis.
