The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset? DOI Creative Commons
Tomoka Ito, Yuumi Nakamura

International Immunology, Journal Year: 2024, Volume and Issue: 36(11), P. 579 - 584

Published: June 18, 2024

Atopic dermatitis (AD), a prevalent Th2-dominant skin disease, involves complex genetic and environmental factors, including mutations in the Filaggrin gene dysbiosis of microbiota characterized by an increased abundance Staphylococcus aureus. Our recent findings emphasize pivotal role barrier's integrity microbial composition infantile AD allergic diseases. Early predisposes infants to AD, suggesting targeted skincare practices as preventive strategy. The effects interventions, particularly application moisturizers with appropriate molar concentration ceramides, cholesterol, fatty acids, play crucial restoring barrier. Notably, our study revealed that can reduce Streptococcus while supporting Cutibacterium acnes presence, thus directly linking modulation neonatal skin. Despite mixed outcomes previous Randomized Controlled Trials on efficacy prevention, research points potential intervention primary method against minimizing impact factors. Furthermore, supports notion early aggressive management eczema may incidence food allergies, highlighting necessity for multifaceted prevention strategies address both barrier immune sensitization. By focusing repairing adjusting skin's microbiome from birth, we propose novel perspective preventing diseases, opening new avenues future studies, allergy prevention.

Language: Английский

The facial microbiome and metabolome across different geographic regions DOI Creative Commons
Rong Tao, Tingting Li, Yalin Wang

et al.

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 12(1)

Published: Dec. 8, 2023

ABSTRACT Facial skin is more exposed to the outside environment, and it usually affected by environmental factors. Characterization of microbiome metabolome individuals from different geographic regions will help understand factors behind prevalence disorders support skincare product development. In current study, volunteers northern, southern, northwestern China were recruited. samples collected for amplicon sequencing metabolomic liquid chromatography‒mass spectrometry (LC–MS/MS) analyses. We demonstrated significant alterations in abundances multiple microorganisms lipid compositions between individuals. People living northwest, which has a dry climate high altitude, showed lower level total lipids, abundance Malassezia , but higher levels ceramides fatty acids. had positive correlation with eicosanoids negative ceramides. This work highlights effects on microbial structures lipids. IMPORTANCE across geography uncover provide suggestions products people regions.

Language: Английский

Citations

1
The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset? DOI Creative Commons
Tomoka Ito, Yuumi Nakamura

International Immunology, Journal Year: 2024, Volume and Issue: 36(11), P. 579 - 584

Published: June 18, 2024

Atopic dermatitis (AD), a prevalent Th2-dominant skin disease, involves complex genetic and environmental factors, including mutations in the Filaggrin gene dysbiosis of microbiota characterized by an increased abundance Staphylococcus aureus. Our recent findings emphasize pivotal role barrier's integrity microbial composition infantile AD allergic diseases. Early predisposes infants to AD, suggesting targeted skincare practices as preventive strategy. The effects interventions, particularly application moisturizers with appropriate molar concentration ceramides, cholesterol, fatty acids, play crucial restoring barrier. Notably, our study revealed that can reduce Streptococcus while supporting Cutibacterium acnes presence, thus directly linking modulation neonatal skin. Despite mixed outcomes previous Randomized Controlled Trials on efficacy prevention, research points potential intervention primary method against minimizing impact factors. Furthermore, supports notion early aggressive management eczema may incidence food allergies, highlighting necessity for multifaceted prevention strategies address both barrier immune sensitization. By focusing repairing adjusting skin's microbiome from birth, we propose novel perspective preventing diseases, opening new avenues future studies, allergy prevention.

Language: Английский

Citations

0