medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 19, 2023
The upper (URT) and lower (LRT) respiratory tract feature distinct environments responses affecting microbial colonization but investigating the relationship between them is technically challenging. We aimed to identify relationships taxa colonizing URT LRT explore their with development during childhood.
Language: Английский
Current Opinion in Microbiology, Journal Year: 2024, Volume and Issue: 77, P. 102428 - 102428
Published: Jan. 25, 2024
The respiratory tract microbiome (RTM) is a microbial ecosystem inhabiting different niches throughout the airway. A critical role for RTM in dictating lung infection outcomes underlined by recent efforts to identify community members benefiting health. Obligate anaerobes common oropharynx and such as Prevotella Veillonella are associated with improved pneumonia activate several immune defense pathways lower Colonizers of nasal cavity, including Corynebacterium Dolosigranulum, directly impact growth virulence pathogens, aligning robust clinical correlations between their upper airway abundance reduced risk. Here, we highlight work identifying bacteria that promote health resilience against disease, focus on infections underlying mechanisms driving RTM-protective benefits.
Language: Английский
Citations
19
Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(5)
Published: April 25, 2024
Abstract Bacteriocins are highly diverse, abundant, and heterogeneous antimicrobial peptides that ribosomally synthesized by bacteria archaea. Since their discovery about a century ago, there has been growing interest in bacteriocin research applications. This is mainly due to high properties, narrow or broad spectrum of activity, specificity, low cytotoxicity, stability. Though initially used improve food quality safety, bacteriocins now globally exploited for innovative applications human, animal, systems as sustainable alternatives antibiotics. have the potential beneficially modulate microbiota, providing viable microbiome-based solutions treatment, management, non-invasive bio-diagnosis infectious non-infectious diseases. The use holds great promise modulation microbiomes, packaging, bio-sanitizers antibiofilm, pre/post-harvest biocontrol, functional food, growth promotion, aquaculture. can undoubtedly security, globally. review highlights current trends research, especially increasing outputs funding, which we believe may proportionate soaring global bacteriocins. cutting-edge technologies, such bioengineering, further enhance exploitation systems.
Language: Английский
Citations
19
Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Jan. 1, 2025
Language: Английский
Citations
3
Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(2)
Published: Jan. 22, 2025
Abstract Over the past two decades, it has become clear that against earlier assumptions, respiratory tract is regularly populated by a variety of microbiota even down to lowest parts lungs. New methods and technologies revealed distinct microbiome compositions developmental trajectories in differing neonates infants. In this review, we describe current understanding development human highlight multiple factors have been identified impact including gestational age, mode delivery, diet, antibiotic treatment, early infections. Moreover, discuss date microbiome–disease associations infants children may indicate potentially imprinting cross talk between microbial communities host immune system tract. It becomes obvious how insufficient our knowledge still regarding exact mechanisms underlying such humans. Lastly, strong findings emphasize important role gut–lung axis educating driving pulmonary immunity. Further research needed better understand – interaction order enable translation into microbiome‐based strategies protect improve health from childhood.
Language: Английский
Citations
2
Poultry Science, Journal Year: 2024, Volume and Issue: 103(8), P. 103942 - 103942
Published: June 5, 2024
Mycoplasma gallisepticum (MG) can cause chronic respiratory disease (CRD) in chickens, which has a significant negative economic impact on the global poultry sector. Respiratory flora is guardian of health, and its disorder closely related to immunity diseases. As common probiotic chicken tract, Lactobacillus salivarius (L. salivarius) potential antioxidant, growth performance enhancing, anti-immunosuppressive properties. However, specific mechanism through L. protects against MG infection not yet been thoroughly examined. This study intends investigate whether could reduce MG-induced tracheal inflammation by modulating microbiota metabolites. The results indicated that reduced colonization significantly alleviated anomalous morphological changes using MG-infection model. also level Th1 cell cytokines, increased Th2 ameliorated immune imbalance during infection. In addition, improved mucosal barrier, heightened function, suppressed Janus kinase/Signal transducer, activator transcription (JAK/STAT) signaling pathway. Notably, changed composition metabolites, therapy partially reversed aberrant metabolite composition. Our highlighted these findings demonstrated played role MG-mediated inflammatory damage salivarius, altering successfully prevent injury trachea.
Language: Английский
Citations
4
Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 70 - 70
Published: Jan. 21, 2025
Heated tobacco products (THPs) are increasingly promoted as potential harm reduction tools, offering an alternative to traditional cigarettes. Despite these claims, understanding of their toxicological impact on respiratory health and associated microbial communities is limited. Comprehensive investigations needed elucidate the biological mechanisms implications with use. Methods: This study evaluated effects aerosols produced by THPs (IQOS 3 Duo Heets “Sienna Selection”) in comparison conventional cigarette smoke (1R6F). Antibacterial activity was using Streptococcus pneumoniae Klebsiella representative species microbiota through agar diffusion assays MIC/MBC determinations. Cytotoxicity assessed human lung fibroblast cells (MRC5) neutral red uptake (NRU) assay, whereas mutagenicity investigated Ames test. Results: THP demonstrated ability inhibit growth both S. K. pneumoniae, exerting bacteriostatic at lower concentrations bactericidal higher concentrations. While antibacterial might initially seem beneficial against pathogens such they raise concerns about disruption balance, particularly relation pneumoniae. microbiological effects, minimal cytotoxicity fibroblasts lacked detectable mutagenic activity, contrasting significant caused smoke. Conclusions: present a reduced short-term profile compared cigarettes; however, microorganisms deserve attention. The observed inhibition commensal bacteria highlights need explore changes ecosystem that could affect health. These findings highlight for additional studies evaluate long-term effect use stability overall ecosystem.
Language: Английский
Citations
0
Pediatric Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Abstract Background The upper and lower respiratory tracts feature distinct environments responses affecting microbial colonization but investigating the relationship between them is technically challenging. We aimed to identify relationships taxa colonizing nasopharynx trachea across childhood. Methods employed V4 16S rRNA gene sequencing profile nasopharyngeal swabs tracheal aspirates collected from 172 subjects 20 weeks 18 years of age. These samples were prior elective procedures over course in 2020 enrolled a cross-sectional study. After extraction, sequencing, quality control, we studied remaining 147 95 aspirates, including 80 subject-matched pairs samples. Results Sequencing data revealed that colonized by few, often highly abundant taxa, while greater diversity. patterns identified correlate with subject age Conclusion Our suggests there are relatively few species colonize both tract trachea. Furthermore, observe pattern change microbiota correlated age, suggesting possible developmental progression Impact airway childhood plays important roles health immune development. In this work, report on paired swab aspirate cohort children infancy years. find unlikely share do not terms show composition strongly stereotypic trajectory during adolescence. results inform our understanding assembly may be used predict disease young children.
Language: Английский
Citations
0
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: April 4, 2025
Abstract The respiratory tract microbiome, a complex ecosystem of microorganisms colonizing the mucous layers and epithelial surfaces along with their associated microenvironment, plays vital role in maintaining function promoting maturation immune system. Current research suggests that environmental changes can disrupt microbiota, potentially leading to disease. This review summarizes existing on impact factors microbiome diseases, aiming offer new insights into prevention treatment
Language: Английский
Citations
0
Animals, Journal Year: 2025, Volume and Issue: 15(8), P. 1116 - 1116
Published: April 12, 2025
Modern, intensive, high-density farming practices cause elevated concentrations of particulate matter (PM) inside livestock barns. PM in barns is predominantly biological, hence, it contains abundant microorganisms. Understanding the microbial composition crucial for assessing hazards air emitted from PM10 and PM2.5 a pig barn were collected winter spring, morphological, chemical, analyses performed. The samples exhibit diverse morphological characteristics. top three elements detected O, C, Si. Other elements, including N, Al, K, Mg, Ca, Na, Zn, P, W, Ba, Fe, S, Cl, Ti, also identified these samples. For bacterial α diversity, Sobs Chao1 indices significantly higher than those (p < 0.05), ACE index was that 0.05). fungal Shannon 0.01), Ace β diversity results indicate season, rather particle size, had significant effect on A total seven pathogen genera 16 allergen In winter, relative abundances pathogens allergens PM10. contrast, abundance spring winter. This study provides comprehensive characterization across sizes seasons.
Language: Английский
Citations
0
Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(5)
Published: April 28, 2025
ABSTRACT The respiratory tract microbiome (RTM) is a multi‐kingdom microbial ecosystem that inhabits various niches of the system. While previously overlooked, there now sufficient evidence RTM plays crucial role in human health related to immune system training and protection against pathogens. Accordingly, dysbiosis or disequilibrium has been linked several communicable non‐communicable diseases, highlighting need unveil its disease. Here, we define place medicine. Moreover, outline challenges research, emphasising for combining methodologies, including multi‐omics computational tools. We also discuss RTM's potential diagnosing, preventing treating diseases developing novel microbiome‐based therapies improve pulmonary health.
Language: Английский
Citations
0