Neurocircuitry of Addiction

Neuropsychopharmacology, Journal Year: 2009, Volume and Issue: 35(1), P. 217 - 238

Published: Aug. 26, 2009

Language: Английский

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Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

Science, Journal Year: 2010, Volume and Issue: 330(6002), P. 385 - 390

Published: Oct. 14, 2010

BDNF, Dopamine, and Cocaine Reward The nucleus accumbens plays a crucial role in mediating the rewarding effects of drugs abuse. Different subpopulations projection neurons exhibit balanced but antagonistic influences on their downstream outputs behaviors. However, roles regulating reward behaviors remains unclear. Lobo et al. (p. 385 ) evaluated two subtypes neurons, those expressing dopamine D1 versus D2 receptors, cocaine reward. Deleting TrkB, receptor for brain-derived neurotrophic factor, selectively each cell type, controlling firing type using optogenetic techniques allowed confirmation that D1- D2-containing produced opposite

Language: Английский

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Neurobiology of the incubation of drug craving

Trends in Neurosciences, Journal Year: 2011, Volume and Issue: 34(8), P. 411 - 420

Published: July 24, 2011

Language: Английский

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Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

Neuron, Journal Year: 2007, Volume and Issue: 56(3), P. 517 - 529

Published: Nov. 1, 2007

Language: Английский

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Decoding the Epigenetic Language of Neuronal Plasticity

Neuron, Journal Year: 2008, Volume and Issue: 60(6), P. 961 - 974

Published: Dec. 1, 2008

Language: Английский

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Neuroplasticity in the mesolimbic dopamine system and cocaine addiction

British Journal of Pharmacology, Journal Year: 2008, Volume and Issue: 154(2), P. 327 - 342

Published: March 17, 2008

The main characteristics of cocaine addiction are compulsive drug use despite adverse consequences and high rates relapse during periods abstinence. A current popular hypothesis is that due to drug-induced neuroadaptations in reward-related learning memory processes, which cause hypersensitivity cocaine-associated cues, impulsive decision making abnormal habit-like learned behaviours insensitive consequences. Here, we review results from studies on the effect exposure selected signalling cascades, growth factors physiological processes previously implicated neuroplasticity underlying normal memory. These include extracellular signal-regulated kinase (ERK) pathway, brain-derived neurotrophic factor (BDNF), glutamate transmission, synaptic plasticity (primarily form long-term potentiation depression, LTP LTD). We also discuss degree these cocaine-induced changes mesolimbic dopamine system mediate psychomotor sensitization cocaine-seeking behaviours, as assessed animal models addiction. Finally, speculate how may interact initiate sustain seeking.

Language: Английский

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Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

British Journal of Pharmacology, Journal Year: 2008, Volume and Issue: 154(2), P. 384 - 396

Published: April 14, 2008

A large range of neuroadaptations develop in response to chronic opioid exposure and these are thought be more or less critical for expression the major features addiction: tolerance, withdrawal processes that may contribute compulsive use relapse. This review considers adaptations at different levels organization nervous system including tolerance mu-opioid receptor itself, cellular opioid-sensitive neurons, systems nerve networks, as well synaptic plasticity sensitive networks. Receptor appears involve enhancement mechanisms regulation, desensitization internalization. Adaptations causing complex but several important have been identified upregulation cAMP/PKA cAMP element-binding signalling perhaps mitogen activated PK cascades neurons might not only influence also during cycles intoxication withdrawal. The potential complexity network, interact with is great some candidate neuropeptide play a role withdrawal, activation glial signalling. Implication forms learning such long term potentiation depression addiction still its infancy this ultimately has identify specific synapses

Language: Английский

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Dynorphin, stress, and depression

Brain Research, Journal Year: 2009, Volume and Issue: 1314, P. 56 - 73

Published: Sept. 25, 2009

Language: Английский

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Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour

Nature, Journal Year: 2011, Volume and Issue: 481(7379), P. 71 - 75

Published: Dec. 6, 2011

Language: Английский

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The Striatal Balancing Act in Drug Addiction: Distinct Roles of Direct and Indirect Pathway Medium Spiny Neurons

Frontiers in Neuroanatomy, Journal Year: 2011, Volume and Issue: 5

Published: Jan. 1, 2011

The striatum plays a key role in mediating the acute and chronic effects of addictive drugs, with drugs abuse causing long-lasting molecular cellular alterations both dorsal nucleus accumbens (ventral striatum). Despite wealth research on biological actions abused striatum, until recently, distinct roles striatum's two major subtypes medium spiny neurons (MSNs) drug addiction remained elusive. Recent advances cell-type-specific technologies, including fluorescent reporter mice, transgenic, or knockout viral-mediated gene transfer, have advanced field toward more comprehensive understanding MSN long-term abuse. Here we review progress defining functional contributions addiction.

Language: Английский

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