Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

Neuron, Journal Year: 2010, Volume and Issue: 68(5), P. 815 - 834

Published: Dec. 1, 2010

Language: Английский

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Optogenetics in Neural Systems

Neuron, Journal Year: 2011, Volume and Issue: 71(1), P. 9 - 34

Published: July 1, 2011

Language: Английский

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The Development and Application of Optogenetics

Annual Review of Neuroscience, Journal Year: 2011, Volume and Issue: 34(1), P. 389 - 412

Published: March 2, 2011

Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues. As the toolbox contents grow and diversify, opportunities for neuroscience continue to grow. In this review, we outline development currently available summarize application various in diverse model organisms.

Language: Английский

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The brain reward circuitry in mood disorders

Nature reviews. Neuroscience, Journal Year: 2013, Volume and Issue: 14(9), P. 609 - 625

Published: Aug. 14, 2013

Language: Английский

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Modulation of Striatal Projection Systems by Dopamine

Annual Review of Neuroscience, Journal Year: 2011, Volume and Issue: 34(1), P. 441 - 466

Published: March 2, 2011

The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal projection systems—so-called direct and indirect pathways—form the functional backbone circuit. Twenty years ago, investigators proposed striatum's ability to use dopamine (DA) rise fall control selection was due segregation D 1 2 DA receptors in direct- indirect-pathway spiny neurons. Although this hypothesis sparked debate, evidence has accumulated since then clearly supports model. Recent advances means marking neural circuits with optical or molecular reporters have revealed clear-cut dichotomy between these two cell types at molecular, anatomical, physiological levels. contrast provided by studies new insights into how striatum responds fluctuations signaling diseases alter change function.

Language: Английский

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Natural Neural Projection Dynamics Underlying Social Behavior

Cell, Journal Year: 2014, Volume and Issue: 157(7), P. 1535 - 1551

Published: June 1, 2014

Language: Английский

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Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Pharmacological Reviews, Journal Year: 2012, Volume and Issue: 64(2), P. 238 - 258

Published: March 8, 2012

Brain derived neurotrophic factor (BDNF) is the most prevalent growth in central nervous system (CNS). It essential for development of CNS and neuronal plasticity. Because BDNF plays a crucial role plasticity brain, it widely implicated psychiatric diseases. This review provides summary clinical preclinical evidence involvement this ubiquitous major depressive disorder, schizophrenia, addiction, Rett syndrome, as well other neurodevelopmental In addition, includes discussion mechanism action pharmacological therapies currently used to treat these diseases, such antidepressants antipsychotics. The also covers critique experimental mimetics discusses value target future drug development.

Language: Английский

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Optogenetics: 10 years of microbial opsins in neuroscience

Nature Neuroscience, Journal Year: 2015, Volume and Issue: 18(9), P. 1213 - 1225

Published: Aug. 26, 2015

Language: Английский

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Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Nature, Journal Year: 2012, Volume and Issue: 493(7433), P. 532 - 536

Published: Dec. 11, 2012

Language: Английский

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Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling

Neuron, Journal Year: 2011, Volume and Issue: 69(4), P. 650 - 663

Published: Feb. 1, 2011

Language: Английский

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