Causes and consequences of representational drift

Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 58, P. 141 - 147

Published: Sept. 27, 2019

Language: Английский

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The Neurobiology of Fear Generalization

Frontiers in Behavioral Neuroscience, Journal Year: 2019, Volume and Issue: 12

Published: Jan. 15, 2019

The generalization of fear memories is an adaptive neurobiological process that promotes survival in complex and dynamic environments. When confronted with a potential threat, animal must select appropriate defensive response based on previous experiences are not identical, weighing cues contextual information may predict safety or danger. Like other aspects memory, mediated by the coordinated actions prefrontal, hippocampal, amygdalar, thalamic brain areas. In this review, we describe our current understanding behavioral, neural, genetic, biochemical mechanisms involved fear. Fear hallmark many anxiety stress-related disorders, while its emergence, severity, manifestation sex-dependent. Therefore, to improve dialogue between human studies as well accelerate development effective therapeutics, emphasize need examine both sex differences remote timescales rodent models.

Language: Английский

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Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(8), P. 3207 - 3219

Published: June 27, 2023

Tremendous strides have been made in our understanding of the neurobiological substrates memory - so-called "engram". Here, we integrate recent progress engram field to illustrate how neurons transform across "lifespan" a from initial encoding, consolidation and retrieval, ultimately forgetting. To do so, first describe cell-intrinsic properties shape emergence at encoding. Second, highlight these encoding preferentially participate synaptic- systems-level memory. Third, changes during guide neural reactivation facilitate recall. Fourth, mechanisms forgetting, can counteract established consolidation, retrieval. Motivated by experimental results four sections, conclude proposing some conceptual extensions traditional view engram, including broadening cell-type participation within engrams stages. In collection, review synthesizes general principles stages, describes future avenues further understand dynamic engram.

Language: Английский

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Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 14, 2025

The evolutionary paths taken by each sex within a given species sometimes diverge, resulting in behavioral differences. Given their distinct needs, the mechanism which learns from shared experience is still an open question. Here, we reveal sexual dimorphism learning: C. elegans males do not learn to avoid pathogenic bacteria PA14 as efficiently and rapidly hermaphrodites. Notably, neuronal activity following pathogen exposure was dimorphic: hermaphrodites generate robust representations, while males, line with behavior, exhibit contrasting representations. Transcriptomic analysis revealed that neuropeptide receptor npr-5, ortholog of mammalian NPY/NPF-like receptor, regulates male learning modulating activity. Furthermore, show dependency males' decision-making on status demonstrate role npr-5 modulator incoming sensory cues. Taken together, these findings illustrate how neuromodulators drive sex-specific plasticity response experience. Experience-dependent vital for survival. authors uncover neuromodulator sex- state-specific elegans, shaping responses.

Language: Английский

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Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

Cell Reports, Journal Year: 2021, Volume and Issue: 37(10), P. 110094 - 110094

Published: Dec. 1, 2021

Cognitive impairment (CI) is a disabling concomitant of multiple sclerosis (MS) with complex and controversial pathogenesis. The cytokine interleukin-17A (IL-17A) involved in the immune pathogenesis MS, but its possible effects on synaptic function cognition are still largely unexplored. In this study, we show that IL-17A receptor (IL-17RA) highly expressed by hippocampal neurons CA1 area exposure to dose-dependently disrupts long-term potentiation (LTP) through activation p38 mitogen-activated protein kinase (MAPK). During experimental autoimmune encephalomyelitis (EAE), overexpression paralleled LTP dysfunction. An vivo behavioral analysis shows visuo-spatial learning abilities preserved when EAE induced mice lacking IL-17A. Overall, study suggests key role for IL-17 axis neuro-immune cross-talk occurring potential involvement dysfunction MS-related CI.

Language: Английский

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Understanding the physical basis of memory: Molecular mechanisms of the engram

Journal of Biological Chemistry, Journal Year: 2022, Volume and Issue: 298(5), P. 101866 - 101866

Published: March 26, 2022

Memory, defined as the storage and use of learned information in brain, is necessary to modulate behavior critical for animals adapt their environments survive. Despite being a cornerstone brain function, questions surrounding molecular cellular mechanisms how encoded, stored, recalled remain largely unanswered. One widely held theory that an engram formed by group neurons are active during learning, which undergoes biochemical physical changes store stable state, later reactivated recall memory. In past decade, development labeling methodologies has proven useful investigate biology memory at levels. Engram technology allows study individual memories associated with particular experiences evolution over time, enough experimental resolution discriminate between different processes: learning (encoding), consolidation (the passage from short-term long-term memories), maintenance brain). Here, we review current understanding formation level focusing on insights provided using technology.

Language: Английский

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Amygdala-hippocampal interactions in synaptic plasticity and memory formation

Neurobiology of Learning and Memory, Journal Year: 2021, Volume and Issue: 184, P. 107490 - 107490

Published: July 21, 2021

Language: Английский

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Excitation–transcription coupling, neuronal gene expression and synaptic plasticity

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(11), P. 672 - 692

Published: Sept. 29, 2023

Language: Английский

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Sleep is required to consolidate odor memory and remodel olfactory synapses

Cell, Journal Year: 2023, Volume and Issue: 186(13), P. 2911 - 2928.e20

Published: June 1, 2023

Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here, we show that, although the Caenorhabditis elegans system has a limited number of neurons, is necessary both processes. In addition, it unclear if, in any system, collaborates experience to alter synapses between specific neurons whether this ultimately affects behavior. C. have defined connections well-described contributions We that spaced odor-training post-training induce long-term memory. Memory consolidation, but not acquisition, requires pair interneurons, AIYs, which play role odor-seeking worms consolidate memory, odor conditioning are required diminish inhibitory AWC chemosensory AIYs. Thus, demonstrate living organism events immediately after training drive structures.

Language: Английский

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Maintenance of a short-lived protein required for long-term memory involves cycles of transcription and local translation

Neuron, Journal Year: 2023, Volume and Issue: 111(13), P. 2051 - 2064.e6

Published: April 25, 2023

Language: Английский

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