Heliyon,
Journal Year:
2024,
Volume and Issue:
10(9), P. e30574 - e30574
Published: April 30, 2024
Hippocampus
is
the
most
widely
studied
brain
area
coupled
with
impairment
of
memory
in
a
variety
neurological
diseases
and
Alzheimer's
disease
(AD).
The
limbic
structures
within
Papez
circuit
have
been
linked
to
various
aspects
cognition.
Unfortunately,
regions
that
include
this
are
often
ignored
terms
understanding
cognitive
decline
these
diseases.
To
properly
comprehend
where
cognition
problems
originate,
it
crucial
clarify
any
aberrant
contributions
from
all
components
specific
-on
both
local
global
level.
pharmacological
treatments
currently
available
not
long
lasting.
Deep
Brain
Stimulation
(DBS)
emerged
as
new
powerful
therapeutic
approach
for
alleviation
dysfunctions.
Metabolic,
functional,
electrophysiological,
imaging
studies
helped
find
out
nodes
can
be
accessible
DBS.
Targeting
produced
significant
improvement
learning
by
disrupting
abnormal
activity
restoring
physiological
network.
Here,
we
provide
an
overview
neuroanatomy
along
mechanisms
deep
stimulation
targets
which
could
improving
dysfunctions
AD.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
162, P. 114647 - 114647
Published: April 1, 2023
With
rapid
aging
of
the
population
worldwide,
number
people
with
dementia
is
dramatically
increasing.
Some
studies
have
emphasized
that
metabolic
syndrome,
which
includes
obesity
and
diabetes,
leads
to
increased
risks
cognitive
decline.
Factors
such
as
insulin
resistance,
hyperglycemia,
high
blood
pressure,
dyslipidemia,
central
in
syndrome
are
associated
synaptic
failure,
neuroinflammation,
imbalanced
neurotransmitter
levels,
leading
progression
dementia.
Due
positive
correlation
between
diabetes
dementia,
some
called
it
"type
3
diabetes".
Recently,
patients
decline
due
imbalances
has
considerably
increased.
In
addition,
recent
reported
neuropsychiatric
issues
anxiety,
depressive
behavior,
impaired
attention
common
factors
disease
those
nervous
system
(CNS),
amygdala
a
region
regulates
emotional
memory,
mood
disorders,
attention,
function.
The
connectivity
other
brain
regions,
hippocampus,
activity
contribute
diverse
neuropathological
issues.
Thus,
this
review
summarizes
significant
consequences
critical
roles
both
syndromes
Further
on
function
imbalance-related
needed
treat
problems
type
Neurosciences,
Journal Year:
2025,
Volume and Issue:
30(1), P. 5 - 19
Published: Jan. 1, 2025
The
hippocampus,
noted
as
(HC),
plays
a
crucial
role
in
the
processes
of
learning,
memory
formation,
and
spatial
navigation.
Recent
research
reveals
that
this
brain
region
can
undergo
structural
functional
changes
due
to
environmental
exposures,
including
stress,
noise
pollution,
sleep
deprivation,
microgravity.
This
review
synthesizes
findings
from
animal
human
studies,
emphasizing
HC's
plasticity
response
these
factors.
It
examines
volume,
architecture,
neurogenesis,
synaptic
plasticity,
gene
expression
highlights
critical
periods
vulnerability
influences
impacting
cognition
behavior.
also
investigates
underlying
mechanisms
such
glucocorticoid
signaling,
epigenetic
alterations,
neural
circuit
adaptations.
Understanding
how
HC
reacts
various
exposures
is
vital
for
developing
strategies
enhance
cognitive
resilience
mitigate
negative
effects
on
region.
Further
needed
identify
protective
risk
factors
create
effective
interventions.
American Journal of Clinical Nutrition,
Journal Year:
2024,
Volume and Issue:
119(3), P. 658 - 668
Published: Feb. 6, 2024
Anthocyanin
and
blueberry
intakes
positively
associated
with
cognitive
function
in
population-based
studies
benefits
randomized
controlled
trials
of
adults
self-perceived
or
clinical
dysfunction.
To
date,
metabolic
syndrome
(MetS)
but
without
dysfunction
are
understudied.
Cognitive
function,
mood,
alertness,
sleep
quality
were
assessed
as
secondary
end
points
MetS
participants,
postprandially
(>24
h)
following
6-mo
intake.
A
double-blind,
trial
was
conducted,
assessing
the
primary
effect
consuming
freeze-dried
powder,
compared
against
an
isocaloric
placebo,
on
cardiometabolic
health
>6
mo
a
24
h
postprandial
period
(at
baseline).
In
this
analysis
main
study,
data
from
those
completing
cognition,
assessments
presented
(i.e.,
n
=
115
6
33
study),
using
following:
1)
Bond-Lader
self-rated
scores,
2)
electronic
battery
testing
attention,
working
memory,
episodic
speed
memory
retrieval,
executive
picture
recognition),
3)
Leeds
Sleep
Evaluation
Questionnaire.
Urinary
serum
anthocyanin
metabolites
quantified,
apolipoprotein
E
genotype
status
determined.
Postprandial
calmness
significantly
improved
after
1
cup
blueberries
(P
0.01;
q
0.04;
11.6%
improvement
baseline
between
0
for
group),
all
other
sleep,
parameters
unaffected
blueberries.
Across
½
groups,
microbial
anthocyanins
chlorogenic
acid
hydroxycinnamic
acids,
benzoic
phenylalanine
derivatives,
hippuric
acids)
catechin
favorable
chronic
calmness.
Although
postprandially,
significant
cognition-metabolite
associations
identified,
our
did
not
support
strong
cognitive,
improvements
participants
intervention.
This
registered
at
clinicaltrials.gov
NCT02035592.
Cyborg and Bionic Systems,
Journal Year:
2024,
Volume and Issue:
5
Published: Jan. 1, 2024
Depression
is
a
common
and
severely
debilitating
neuropsychiatric
disorder.
Multiple
studies
indicate
strong
correlation
between
the
occurrence
of
immunological
inflammation
presence
depression.
The
basolateral
amygdala
(BLA)
crucial
in
cognitive
physiological
processing
control
emotion.
However,
due
to
lack
detection
tools,
neural
activity
BLA
during
depression
not
well
understood.
In
this
study,
microelectrode
array
(MEA)
based
on
shape
anatomical
location
brain
was
designed
manufactured.
Rats
were
injected
with
lipopolysaccharide
(LPS)
for
7
consecutive
days
induce
depressive
behavior.
We
used
MEA
detect
before
modeling,
after
LPS
administration
days.
results
showed
that
treatment,
spike
firing
neurons
region
rats
gradually
became
more
intense,
local
field
potential
power
also
increased
progressively.
Further
analysis
revealed
administration,
predominantly
theta
rhythm,
obvious
periodic
characteristics
appearing
d
relative
band
significantly
increased.
summary,
our
suggest
enhanced
related
state
rats,
providing
valuable
guidance
research
into
mechanisms
Journal of Integrative Neuroscience,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 21, 2025
Background:
Volume
alterations
in
the
parietal
subregion
have
received
less
attention
Alzheimer’s
disease
(AD),
and
their
role
predicting
conversion
of
mild
cognitive
impairment
(MCI)
to
AD
cognitively
normal
(CN)
MCI
remains
unclear.
In
this
study,
we
aimed
assess
volumetric
variation
at
different
stages
determine
subregions
CN
conversion.
Methods:
We
included
662
participants
from
Disease
Neuroimaging
Initiative
(ADNI)
database,
including
228
CN,
221
early
(EMCI),
112
late
(LMCI),
101
participants.
measured
volume
based
on
Human
Brainnetome
Atlas
(BNA-246)
using
voxel-based
morphometry
among
individuals
various
progressive
stable
MCI.
then
calculated
area
under
curve
(AUC)
receiver
operating
characteristic
(ROC)
test
ability
discriminate
between
groups.
The
Cox
proportional
hazard
model
was
constructed
which
specific
subregions,
alone
or
combination,
could
be
used
predict
progression
Finally,
examined
relationship
scores
diagnostic
Results:
left
inferior
lobule
(IPL)_6_5
(rostroventral
39)
showed
best
patients
with
those
(AUC
=
0.688).
consisting
IPL_6_4
(caudal
40)
bilateral
IPL_6_5
combination
for
IPL_6_1
predictive
power
AD.
Certain
correlated
scales.
Conclusion:
Subregions
angular
gyrus
are
essential
onset
subsequent
development
AD,
detection
these
regions
may
useful
identifying
tendency
develop
its
treatment.
