Neural Circuits of Interoception

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 44(1), P. 17 - 28

Published: Dec. 29, 2020

Language: Английский

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Cardiogenic control of affective behavioural state

Nature, Journal Year: 2023, Volume and Issue: 615(7951), P. 292 - 299

Published: March 1, 2023

Abstract Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of heart 1–3 . However, whether an increased rate might itself induce or fear responses is unclear 3–8 Physiological theories emotion, proposed over a century ago, have considered that general, there could be important and even dominant flow information from body to brain 9 Here, formally test this idea, we developed noninvasive optogenetic pacemaker for precise, cell-type-specific control cardiac rhythms up 900 beats per minute freely moving mice, enabled wearable micro-LED harness systemic viral delivery potent pump-like channelrhodopsin. We found optically evoked tachycardia potently enhanced anxiety-like behaviour, but crucially only risky contexts, indicating both central (brain) peripheral (body) processes may involved development emotional states. To identify potential mechanisms, used whole-brain activity screening electrophysiology find regions were activated imposed rhythms. identified posterior insular cortex mediator bottom-up interoceptive processing, inhibition region attenuated behaviour was induced optical pacing. Together, these findings reveal cells must together understand origins affective More broadly, our results define generalizable approach noninvasive, temporally precise functional investigations joint organism-wide interactions among targeted during behaviour.

Language: Английский

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Interventions and Manipulations of Interoception

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 44(1), P. 52 - 62

Published: Dec. 29, 2020

Language: Английский

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Anterior insula as a gatekeeper of executive control

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 139, P. 104736 - 104736

Published: June 11, 2022

Executive control is a complex high-level cognitive function that relies on distributed brain circuitry. We propose the anterior insular cortex plays an under-appreciated role in executive processes, acting as gatekeeper to other regions and networks by virtue of primacy action effective connectivity. The flexible functional profile subdivision renders it key hub within broader midcingulo-insular 'salience network', allowing orchestrate drive activity major including medial frontoparietal 'default mode network' lateral 'central network'. microanatomy large-scale connectivity positions play critical triaging integrating internal external multisensory stimuli service initiating higher-order functions. Multiple lines evidence scaffold novel hypothesis that, for integration lever network switching, insula serves control.

Language: Английский

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A multidimensional coding architecture of the vagal interoceptive system

Nature, Journal Year: 2022, Volume and Issue: 603(7903), P. 878 - 884

Published: March 16, 2022

Abstract Interoception, the ability to timely and precisely sense changes inside body, is critical for survival 1–4 . Vagal sensory neurons (VSNs) form an important body-to-brain connection, navigating visceral organs along rostral–caudal axis of body crossing surface–lumen into appropriate tissue layers 5,6 The brain can discriminate numerous signals through VSNs, but underlying coding strategy remains poorly understood. Here we show that VSNs code organ, layer stimulus modality—three key features interoceptive signal—in different dimensions. Large-scale single-cell profiling from seven major in mice using multiplexed projection barcodes reveals a ‘visceral organ’ dimension composed differentially expressed gene modules body’s axis. We discover another ‘tissue layer’ with locations VSN endings organs. Using calcium-imaging-guided spatial transcriptomics, are organized functional units similar stimuli across layers; this constitutes third ‘stimulus modality’ dimension. three independent feature-coding dimensions together specify many parallel pathways combinatorial manner facilitate complex brainstem. Our study highlights multidimensional architecture mammalian vagal system effective signal communication.

Language: Английский

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The role of the salience network in cognitive and affective deficits

Frontiers in Human Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 20, 2023

Analysis and interpretation of studies on cognitive affective dysregulation often draw upon the network paradigm, especially Triple Network Model, which consists default mode (DMN), frontoparietal (FPN), salience (SN). DMN activity is primarily dominant during leisure self-monitoring processes. The FPN peaks task involvement exertion. Meanwhile, SN serves as a dynamic “switch” between FPN, in line with demand. In domains, dysfunctions involving are connected to broad spectrum deficits maladaptive behavioral patterns variety clinical disorders, such depression, insomnia, narcissism, PTSD (in case hyperactivity), chronic pain, anxiety, high degrees neuroticism, schizophrenia, epilepsy, autism, neurodegenerative illnesses, bipolar disorder hypoactivity). We discuss neurological data from various research domains present an integrated perspective indicating that these conditions can be associated widespread disruption predictive coding at multiple hierarchical levels. delineate fundamental ideas brain paradigm contrast them conventional modular method first section this article. Following this, we outline interaction model key functional networks highlight recent coupling SN-related impairments.

Language: Английский

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Atypical interoception as a common risk factor for psychopathology: A review

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 130, P. 470 - 508

Published: Aug. 3, 2021

The inadequacy of a categorial approach to mental health diagnosis is now well-recognised, with many authors, diagnostic manuals and funding bodies advocating dimensional, trans-diagnostic research. Variance in interoception, the ability perceive one's internal bodily state, reported across boundaries, associated atypical functioning symptom categories. Drawing on behavioural neuroscientific evidence, we outline current research contribution interoception numerous cognitive affective abilities (in both typical clinical populations), describe interoceptive atypicalities seen range psychiatric conditions. We discuss role that may play development maintenance psychopathology, as well ways which differ presentations. A number important areas for further psychopathology are highlighted.

Language: Английский

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Interoception of breathing and its relationship with anxiety

Neuron, Journal Year: 2021, Volume and Issue: 109(24), P. 4080 - 4093.e8

Published: Oct. 22, 2021

Interoception, the perception of internal bodily states, is thought to be inextricably linked affective qualities such as anxiety. Although interoception spans sensory metacognitive processing, it not clear whether anxiety differentially related these processing levels. Here we investigated this question in domain breathing, using computational modeling and high-field (7 T) fMRI assess brain activity relating dynamic changes inspiratory resistance varying predictability. Notably, anterior insula was associated with both breathing-related prediction certainty errors, suggesting an important role representing updating models body. Individuals low versus moderate traits showed differential for certainty. Multi-modal analyses data from fMRI, assessments metacognition, questionnaires demonstrated that anxiety-interoception links span all levels perceptual sensitivity strong effects seen at higher interoceptive processes.

Language: Английский

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The heart rate discrimination task: A psychophysical method to estimate the accuracy and precision of interoceptive beliefs

Biological Psychology, Journal Year: 2021, Volume and Issue: 168, P. 108239 - 108239

Published: Dec. 11, 2021

Interoception - the physiological sense of our inner bodies has risen to forefront psychological and psychiatric research. Much this research utilizes tasks that attempt measure ability accurately detect cardiac signals. Unfortunately, these approaches are confounded by well-known issues limiting their validity interpretation. At core controversy is role subjective beliefs about heart rate in confounding measures interoceptive accuracy. Here, we recast as an important part causal machinery interoception, offer a novel psychophysical "heart discrimination" method estimate accuracy precision. By applying task 223 healthy participants, demonstrate more biased, less precise, associated with poorer metacognitive insight relative exteroceptive control condition. Our task, provided open-source python package, offers robust approach quantifying beliefs.

Language: Английский

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Interoception and the origin of feelings: A new synthesis

BioEssays, Journal Year: 2021, Volume and Issue: 43(6)

Published: March 24, 2021

Feelings are conscious mental events that represent body states as they undergo homeostatic regulation. depend on the interoceptive nervous system (INS), a collection of peripheral and central pathways, nuclei cortical regions which continuously sense chemical anatomical changes in organism. How such humoral neural signals come to generate has been major scientific question. The answer proposed here invokes (1) several distinctive poorly known physiological features INS; (2) unique interaction between (the 'object' interoception) (which generates 'subject' interoception). atypical traits INS direct interactions non-neural compartments organism, neither is present exteroceptive systems, plausibly explain qualitative subjective aspects feelings, thus accounting for their nature.

Language: Английский

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