Cell Reports Medicine,
Journal Year:
2023,
Volume and Issue:
4(1), P. 100895 - 100895
Published: Jan. 1, 2023
Controlled
breathwork
practices
have
emerged
as
potential
tools
for
stress
management
and
well-being.
Here,
we
report
a
remote,
randomized,
controlled
study
(NCT05304000)
of
three
different
daily
5-min
exercises
compared
with
an
equivalent
period
mindfulness
meditation
over
1
month.
The
breathing
conditions
are
(1)
cyclic
sighing,
which
emphasizes
prolonged
exhalations;
(2)
box
breathing,
is
equal
duration
inhalations,
breath
retentions,
(3)
hyperventilation
retention,
longer
inhalations
shorter
exhalations.
primary
endpoints
improvement
in
mood
anxiety
well
reduced
physiological
arousal
(respiratory
rate,
heart
rate
variability).
Using
mixed-effects
model,
show
that
breathwork,
especially
the
exhale-focused
produces
greater
(p
<
0.05)
reduction
respiratory
meditation.
Daily
sighing
has
promise
effective
exercise.
Frontiers in Psychiatry,
Journal Year:
2021,
Volume and Issue:
12
Published: June 2, 2021
Psychiatry
faces
fundamental
challenges
with
regard
to
mechanistically
guided
differential
diagnosis,
as
well
prediction
of
clinical
trajectories
and
treatment
response
individual
patients.
This
has
motivated
the
genesis
two
closely
intertwined
fields:
(i)
Translational
Neuromodeling
(TN),
which
develops
“computational
assays”
for
inferring
patient-specific
disease
processes
from
neuroimaging,
electrophysiological,
behavioral
data;
(ii)
Computational
(CP),
goal
incorporating
computational
assays
into
decision
making
in
everyday
practice.
In
order
serve
objective
reliable
tools
routine,
require
end-to-end
pipelines
raw
data
(input)
clinically
useful
information
(output).
While
these
are
yet
be
established
practice,
components
this
general
pipeline
being
developed
made
openly
available
community
use.
paper,
we
present
T
ranslational
A
lgorithms
P
sychiatry-
dvancing
S
cience
(TAPAS)
software
package,
an
open-source
collection
building
blocks
psychiatry.
Collectively,
TAPAS
presently
cover
several
important
aspects
desired
pipeline,
including:
tailored
experimental
designs
optimization
measurement
strategy
prior
acquisition,
quality
control
during
(iii)
artifact
correction,
statistical
inference,
application
after
acquisition.
Here,
review
different
within
illustrate
how
may
help
provide
a
deeper
understanding
neural
cognitive
mechanisms
disease,
ultimate
establishing
automatized
predictions
about
We
hope
that
will
contribute
further
development
TN/CP
facilitate
translation
advances
neuroscience
relevant
assays.
BMJ Open,
Journal Year:
2022,
Volume and Issue:
12(2), P. e056366 - e056366
Published: Feb. 1, 2022
To
explore
the
lived
experience
of
'brain
fog'-the
wide
variety
neurocognitive
symptoms
that
can
follow
COVID-19.A
UK-wide
longitudinal
qualitative
study
comprising
online
focus
groups
with
email
follow-up.50
participants
were
recruited
from
a
previous
long
COVID-19
(n=23)
and
support
for
people
persistent
following
(n=27).
In
remotely
held
groups,
invited
to
describe
their
comment
on
others'
accounts.
Individuals
followed
up
by
4-6
months
later.
Data
audiotaped,
transcribed,
anonymised
coded
in
NVIVO.
They
analysed
an
interdisciplinary
team
expertise
general
practice,
clinical
neuroscience,
sociology
chronic
illness
service
delivery,
checked
brain
fog.Of
50
participants,
42
female
32
white
British.
Most
had
never
been
hospitalised
COVID-19.
Qualitative
analysis
revealed
themes:
mixed
views
appropriateness
term
fog';
rich
descriptions
(especially
executive
function,
attention,
memory
language),
accounts
how
fluctuated-and
progressed
over
time;
profound
psychosocial
impact
condition
relationships,
personal
professional
identity;
self-perceptions
guilt,
shame
stigma;
strategies
used
self-management;
challenges
accessing
navigating
healthcare
system;
participants'
search
physical
mechanisms
explain
symptoms.These
findings
complement
research
into
epidemiology
after
Services
such
patients
should
include:
ongoing
therapeutic
relationship
clinician
who
engages
its
personal,
social
occupational
context
as
well
specialist
services
include
provision
symptoms,
are
accessible,
easily
navigable,
comprehensive
interdisciplinary.
Cell Metabolism,
Journal Year:
2023,
Volume and Issue:
35(4), P. 571 - 584.e6
Published: March 22, 2023
Western
diets
rich
in
fat
and
sugar
promote
excess
calorie
intake
weight
gain;
however,
the
underlying
mechanisms
are
unclear.
Despite
a
well-documented
association
between
obesity
altered
brain
dopamine
function,
it
remains
elusive
whether
these
alterations
(1)
pre-existing,
increasing
individual
susceptibility
to
gain,
(2)
secondary
obesity,
or
(3)
directly
attributable
repeated
exposure
western
diet.
To
close
this
gap,
we
performed
randomized,
controlled
study
(NCT05574660)
with
normal-weight
participants
exposed
high-fat/high-sugar
snack
low-fat/low-sugar
for
8
weeks
addition
their
regular
The
intervention
decreased
preference
low-fat
food
while
response
associative
learning
independent
of
cues
reward.
These
were
changes
body
metabolic
parameters,
indicating
direct
effect
high-fat,
high-sugar
foods
on
neurobehavioral
adaptations
that
may
increase
risk
overeating
gain.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 11, 2025
Abstract
Anxiety
is
an
interactive
disorder
of
the
mind
and
body,
characterized
by
excessive
worry
about
uncertain
future
events
a
dysfunction
autonomic
nervous
system.
Previous
studies
have
shown
that
slow,
deep
breathing
can
reduce
physical
tension,
anxiety.
Although
we
know
slow
techniques
effectively
regulate
anxiety
other
emotions,
psychological
neurophysiological
mechanisms
on
not
been
systematically
explored.
In
study,
combined
paced
task
with
threat
uncertainty
for
first
time
to
investigate
role
in
regulating
Here
investigated
this
question,
using
Spectral
analysis
Time-frequency
domain
EEG
assess
brain
activity
relating
respiratory
rate
mechanism
impact
anxious.
Twenty-seven
individuals
participated
experiment,
which
followed
2
(respiratory
rate:
fast
breathing,
breathing)
×
(certainty:
certain,
uncertain)
within-subjects
design.
The
results
showed
that:
(1)
Slow
reduced
anxiety,
valence
arousal
are
lower
under
breathing.
(2)
different
characteristics.
There
overall
increase
power
during
delta,
theta,
alpha
beta
bands.(3)
interaction
certainty
were
closely
related
beta.
uncertain,
decreased
but
increased
Psychological Review,
Journal Year:
2022,
Volume and Issue:
130(4), P. 1066 - 1080
Published: Aug. 18, 2022
Respiratory
rhythms
sustain
biological
life,
governing
the
homeostatic
exchange
of
oxygen
and
carbon
dioxide.Until
recently,
however,
influence
breathing
on
brain
has
largely
been
overlooked.Yet
new
evidence
demonstrates
that
act
exerts
a
substantive,
rhythmic
perception,
emotion,
cognition,
through
direct
modulation
neural
oscillations.Here,
we
synthesize
these
findings
to
motivate
predictive
coding
model
respiratory
coupling,
in
which
rhythmically
modulates
both
local
global
gain,
optimize
cognitive
affective
processing.Our
further
explains
how
interact
with
topology
functional
connectome,
highlight
key
implications
for
computational
psychiatry
disordered
interoceptive
inference.
