Traumatic brain Injury: Comprehensive overview from pathophysiology to Mesenchymal stem Cell-Based therapies DOI
Mahsa Hajivalili,

Nima Nikkhoo,

Sarvenaz Salahi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113816 - 113816

Published: Dec. 20, 2024

Language: Английский

Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule Cells DOI Creative Commons
Akshay Gupta,

Laura Dovek,

Archana Proddutur

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: March 14, 2022

Progressive physiological changes in the hippocampal dentate gyrus circuits following traumatic brain injury (TBI) contribute to temporal evolution of neurological sequelae. Although early posttraumatic synaptic and extrasynaptic GABA currents have been reported, whether they evolve over time remain distinct between two projection neuron classes, granule cells semilunar cells, not evaluated. We examined long-term tonic spontaneous inhibitory postsynaptic (sIPSCs) neurons 3 months after moderate concussive fluid percussion (FPI) adolescent rats. Granule cell current amplitude remained elevated up 1 month FPI, but decreased levels comparable with age-matched controls by postinjury. sIPSC frequency, which we previously reported be increased week higher than at was significantly reduced FPI. In frequency were different from contrast decreases observed injury. The switch inputs increase subsequent decrease could delayed emergence cognitive deficits seizure susceptibility

Language: Английский

Citations

7
The ECG abnormalities in persons with chronic disorders of consciousness DOI
Xiaodan Tan, Minmin Luo,

Qiuyi Xiao

et al.

Medical & Biological Engineering & Computing, Journal Year: 2024, Volume and Issue: 62(10), P. 3013 - 3023

Published: May 15, 2024

Language: Английский

Citations

0
Traumatic brain injury-induced peripheral damage: The dynamics of the inflammatory and autophagy pathway from acute to chronic stages DOI Creative Commons
Züleyha Doğanyiğit, Serpil Taheri, Aslı Okan

et al.

Folia Neuropathologica, Journal Year: 2024, Volume and Issue: 62(3), P. 277 - 292

Published: Jan. 1, 2024

Traumatic brain injury (TBI) is one of the major causes death and disability worldwide, brings a huge burden on quality life patients with TBI country's healthcare system. Peripheral organs, especially kidney, liver, may be affected by onset molecular responses following tissue damage. While secondary post has been well studied in brain, effect/consequences these peripheral organs have not yet fully elucidated. Thus, our study aimed to investigate immunoreactivity responses, particularly via proinflammatory cytokines autophagy markers kidney liver post-acute chronic TBI.

Language: Английский

Citations

0
Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC–MS-Based Plasma Profiling DOI
Ruchi Baghel, Kiran Maan, Seema Dhariwal

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Language: Английский

Citations

0
Traumatic brain Injury: Comprehensive overview from pathophysiology to Mesenchymal stem Cell-Based therapies DOI
Mahsa Hajivalili,

Nima Nikkhoo,

Sarvenaz Salahi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113816 - 113816

Published: Dec. 20, 2024

Language: Английский

Citations

0