Sex-specific behavioral and thalamo-accumbal circuit adaptations after oxycodone abstinence DOI Open Access
Yanaira Alonso‐Caraballo, Yan Li, Nicholas J. Constantino

et al.

Published: Jan. 13, 2025

Opioid use disorder is marked by a progressive change in the motivation to administer drug even presence of negative consequences. After long periods abstinence, urge return taking intensifies over time, known as incubation craving. Conditioned responses drug-related stimuli, can acquire motivational properties and exert control motivated behaviors leading relapse. Although, preclinical data suggest that behavioral expression opioid similar between male female rodents, we do not have conclusive results on sex differences craving relapse across abstinence periods. Here, investigated effects from oxycodone self-administration neurotransmission paraventricular thalamus (PVT) nucleus accumbens shell (NAcSh) pathway rats. Using optogenetics ex vivo electrophysiology, assessed synaptic strength glutamate release probability this pathway, well NAcSh medium spiny neurons (MSN) intrinsic excitability, slices rats which were subjected either 1 (acute) or 14 (prolonged) days forced after self-administration. Our revealed no somatic withdrawal symptoms following acute abstinence. However, found sex-specific enhancement cue-induced prolonged, but acute, self-administration, with females exhibiting higher rates. Notably, prolonged led increases at PVT-NAcSh inputs compared saline controls both sexes, was observed Thus, time-dependent increase These findings leads significant changes, contributing heightened vulnerability, highlighting need for targeted therapeutic strategies disorder.

Language: Английский

Interoceptive rhythms in the brain DOI
Tahnée Engelen, Marco Solcà, Catherine Tallon‐Baudry

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1670 - 1684

Published: Sept. 11, 2023

Language: Английский

Citations

86
Rescue-like behavior in a bystander mouse toward anesthetized conspecifics promotes arousal via a tongue-brain connection DOI Creative Commons
Peng Cao, Ying Liu, Ziyun Ni

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(4)

Published: Jan. 22, 2025

Prosocial behaviors are advantageous to social species, but the neural mechanism(s) through which others receive benefit remain unknown. Here, we found that bystander mice display rescue-like behavior (tongue dragging) toward anesthetized cagemates and this tongue dragging promotes arousal from anesthesia a direct tongue-brain circuit. We circuit → glutamatergic neurons in mesencephalic trigeminal nucleus (MTN Glu ) noradrenergic locus coeruleus (LC NE drives rapid bystanders. Artificial inhibition of abolishes effect induced by behavior. Further, revealed paraventricular thalamus (PVT project accumbens shell (NAcSh) mediate These findings reveal connection underlying effects basis governing specific form prosocial

Language: Английский

Citations

6
Refocusing neuroscience: moving away from mental categories and towards complex behaviours DOI Creative Commons
Luiz Pessoa, Loreta Medina, Ester Desfilis

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2021, Volume and Issue: 377(1844)

Published: Dec. 27, 2021

Mental terms-such as perception, cognition, action, emotion, well attention, memory, decision-making-are epistemically sterile. We support our thesis based on extensive comparative neuroanatomy knowledge of the organization vertebrate brain. Evolutionary pressures have moulded central nervous system to promote survival. Careful characterization brain shows that its architecture supports an enormous amount communication and integration signals, especially in birds mammals. The general a degree 'computational flexibility' enables animals cope successfully with complex ever-changing environments. Here, we suggest neuroarchitecture does not respect boundaries standard mental terms, propose neuroscience should aim unravel dynamic coupling between large-scale circuits complex, naturalistic behaviours. This article is part theme issue 'Systems through lens evolutionary theory'.

Language: Английский

Citations

90
Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors DOI
Jun Ma, Johann du Hoffmann, Morgan Kindel

et al.

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(10), P. 1429 - 1440

Published: Aug. 19, 2021

Language: Английский

Citations

68
Structural and functional organization of the midline and intralaminar nuclei of the thalamus DOI Creative Commons
Robert P. Vertes, Stephanie B. Linley,

Amanda K. P. Rojas

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 23, 2022

The midline and intralaminar nuclei of the thalamus form a major part "limbic thalamus;" that is, thalamic structures anatomically functionally linked with limbic forebrain. consist paraventricular (PV) paratenial nuclei, dorsally rhomboid nucleus reuniens (RE), ventrally. rostral (ILt) central medial (CM), paracentral (PC) lateral (CL) nuclei. We presently concentrate on RE, PV, CM CL thalamus. receives diverse array input from limbic-related sites, predominantly projects to hippocampus "limbic" cortices. RE participates in various cognitive functions including spatial working memory, executive (attention, behavioral flexibility) affect/fear behavior. PV significant afferents, particularly hypothalamus, mainly distributes "affective" forebrain bed stria terminalis, accumbens amygdala. Accordingly, serves critical role "motivated behaviors" such as arousal, feeding/consummatory behavior drug addiction. ILt both sensorimotor-related widely over motor regions frontal cortex-and throughout dorsal striatum. is for maintaining consciousness directly sensorimotor (visuospatial or reaction time tasks) tasks involving striatal-cortical interactions. As discussed herein, while each are distinct, they collectively serve vital several affective, behaviors - components brainstem-diencephalic-thalamocortical circuitry.

Language: Английский

Citations

41
Paraventricular thalamus controls consciousness transitions during propofol anaesthesia in mice DOI Creative Commons

Yulong Wang,

Lu Wang, Wei Xu

et al.

British Journal of Anaesthesia, Journal Year: 2023, Volume and Issue: 130(6), P. 698 - 708

Published: Feb. 23, 2023

Language: Английский

Citations

31
Prefrontal modulation of anxiety through a lens of noradrenergic signaling DOI Creative Commons

Nadia N. Bouras,

Nancy R. Mack, Wen‐Jun Gao

et al.

Frontiers in Systems Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: April 17, 2023

Anxiety disorders are the most common class of mental illness in U.S., affecting 40 million individuals annually. is an adaptive response to a stressful or unpredictable life event. Though evolutionarily thought aid survival, excess intensity duration anxiogenic can lead plethora adverse symptoms and cognitive dysfunction. A wealth data has implicated medial prefrontal cortex (mPFC) regulation anxiety. Norepinephrine (NE) crucial neuromodulator arousal vigilance believed be responsible for many anxiety disorders. NE synthesized locus coeruleus (LC), which sends major noradrenergic inputs mPFC. Given unique properties LC-mPFC connections heterogeneous subpopulation neurons known involved regulating anxiety-like behaviors, likely modulates PFC function cell-type circuit-specific manner. In working memory stress response, follows inverted-U model, where overly high low release associated with sub-optimal neural functioning. contrast, based on current literature review individual contributions disorders, we propose model level- adrenergic receptor-dependent, NE-PFC modulation Further, advent new techniques measure unprecedented spatial temporal resolution will significantly help us understand how

Language: Английский

Citations

28
Molecular and spatial profiling of the paraventricular nucleus of the thalamus DOI Creative Commons
Claire Gao, Chiraag Gohel, Yan Leng

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 3, 2023

The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked cellular differences, molecular identity spatial distribution cell types remain unclear. To address this gap, here we used single RNA sequencing (snRNA-seq) identified five molecularly distinct neuronal subtypes in mouse brain. Additionally, multiplex fluorescent situ hybridization top marker genes revealed that are organized by a combination previously unidentified gradients. Lastly, comparing our dataset with recently published single-cell atlas yielded novel insight into PVT’s connectivity cortex, including unexpected innervation auditory visual areas. This comparison also data contains largely non-overlapping transcriptomic map multiple midline thalamic nuclei. Collectively, findings uncover unknown features anatomical organization provide valuable resource for future investigations.

Language: Английский

Citations

24
Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala DOI Creative Commons
Robin Nguyen,

Konstantinos Koukoutselos,

Thomas Forro

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(22)

Published: May 31, 2023

Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it poorly understood whether representations are imbued with emotional values support selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during formation of cued fear extinction memory. During when CS acquire safety properties, found CS-related activity vH reactivated sleep consolidation was strengthened upon retrieval. Moreover, facilitated context exhibited precise coding its affective zones. Last, these patterns along were dependent on glutamatergic transmission BLA learning. Thus, relies stimulus instructed BLA.

Language: Английский

Citations

23
Dissociable encoding of motivated behavior by parallel thalamo-striatal projections DOI Creative Commons

Sofia Beas,

Isbah Khan,

Claire Gao

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(7), P. 1549 - 1560.e3

Published: March 7, 2024

The successful pursuit of goals requires the coordinated execution and termination actions that lead to positive outcomes. This process relies on motivational states are guided by internal drivers, such as hunger or fear. However, mechanisms which brain tracks shape instrumental not fully understood. paraventricular nucleus thalamus (PVT) is a midline thalamic shapes motivated behaviors via its projections accumbens (NAc)

Language: Английский

Citations

9