Published: Jan. 1, 2024
Language: Английский
Cancer Letters, Journal Year: 2025, Volume and Issue: 611, P. 217451 - 217451
Published: Jan. 8, 2025
Language: Английский
Citations
2
Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217132 - 217132
Published: July 24, 2024
Language: Английский
Citations
12
Biomolecules, Journal Year: 2023, Volume and Issue: 13(7), P. 1136 - 1136
Published: July 15, 2023
During evolution, the development of bone was critical for many species to thrive and function in boundary conditions Earth. Furthermore, also became a storehouse calcium that could be mobilized reproductive purposes mammals other species. The nature both needs during evolution context Earth has led complex regulatory mechanisms require integration optimization this tissue across lifespan. Three important variables include mechanical loading, sex hormones, innervation/neuroregulation. importance loading been target much research as appears subscribe “use it or lose it” paradigm. because post-menopausal osteoporosis risk fractures loss function, aspect regulation focused on differences regulation. advent space flight exposure microgravity renewed interest unique environment, which not have anticipated by expose new insights into Finally, body evidence emerged indicating neuroregulation is central maintaining function. However, there still more needed understand regarding how such are integrated lifespan maintain particularly walks upright. This review will attempt discuss these elements integrity propose further study delineate details better improve treatments those at integrity, state prolonged flight.
Language: Английский
Citations
12
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)
Published: March 1, 2024
Abstract Aim We aim to identify the specific CD4 + T‐cell subtype influenced by brain‐to‐CLN signaling and explore their role during acute phase of traumatic brain injury (TBI). Method Cervical lymphadenectomy or cervical afferent lymphatic ligation was performed before TBI. Cytokine array western blot were used detect cytokines, while motor function assessed using mNss rotarod test. subtypes in blood, brain, CLNs analyzed with Cytometry time‐of‐flight analysis (CyTOF) fluorescence‐activated cell sorting (FACS). Brain edema volume changes measured 9.4T MRI. Neuronal apoptosis evaluated terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) staining. Results vessels resulted a decreased infiltration T cells, specifically CD11b‐positive within affected region. The population CD11b cells increased ligated CLNs, accompanied decrease average fluorescence intensity sphingosine‐1‐phosphate receptor‐1 (S1PR1) on these cells. Administration sorted from into lateral ventricle reversed attenuated neurologic deficits, edema, lesion following lymphadenectomy. Conclusion exacerbates secondary damage TBI, this process is modulated signaling.
Language: Английский
Citations
4
Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 78, P. 14 - 24
Published: July 15, 2024
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide (Ozempic®), have emerged effective treatments for diabetes and weight management. However, recent evidence indicates that GLP-1R signalling influences various tissues, including the immune system. Notably, GLP-1 has a short half-life (< 5 minutes) exists in picomolar range, while GLP-1RAs like extended half-lives of several days are administered at supraphysiological doses. This review explores potential impact these medications on vaccine efficacy. We examine suggesting may attenuate responses through direct effects cells modulation other tissues. Additionally, we discuss how create tolerogenic environment, potentially reducing immunogenicity. Given widespread use GLP-1RAs, it is crucial to understand their translational implications vaccination outcomes.
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 19, 2025
The thymus is a primary lymphoid organ critical for the development of mature T cells from hematopoietic progenitors. A highly structured organ, contains distinct regions, precise cytoarchitecture, and molecular signals tightly regulating thymopoiesis. Although above are well-understood, structural functional implications thymic innervation largely neglected. In general, neural regulation has become increasingly identified as component immune cell function. central nervous system (CNS) in brain coordinates these immunological responses both by direct through peripheral nerves neuroendocrine signaling. Yet how signals, particularly innervation, may regulate biology unclear understudied. this review, we highlight historical current data demonstrating input to assess evidence We further discuss knowledge gaps summarize recent advances techniques that could be used study microenvironment.
Language: Английский
Citations
0
Cellular Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104963 - 104963
Published: May 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 12, 2023
The central nervous system (CNS) influences the immune generally by regulating systemic concentration of humoral substances (e.g., cortisol and epinephrine), whereas peripheral (PNS) communicates specifically with according to local interactions/connections. An imbalance between components PNS might contribute pathogenesis further development certain diseases. In this review, we have explored "thread" (hardwiring) connections primary/secondary/tertiary lymphoid tissues/organs) sensory, sympathetic, parasympathetic, enteric systems (ENS)) in health disease
Language: Английский
Citations
9
Rejuvenation Research, Journal Year: 2024, Volume and Issue: 27(3), P. 102 - 109
Published: April 26, 2024
Elevated substance P can be utilized to predict early mortality during the first week of cerebral infarction. Whether aprepitant, a receptor blocker could alleviate poststroke pneumonia which is investigated in this study. Intraluminal monofilament model middle artery occlusion (MCAO) was constructed C57BL/6J male mice, and relative expression detected collected bronchoalveolar lavage fluid (BALF) lung tissue homogenate at 24 hours, 48 72 hours poststroke. On other hand, different concentrations aprepitant (0.5, 1, 2 mg/kg) were atomized inhaled into MCAO mice. Inflammation cytokines bacterial load BALF 72-hour poststroke, injury revealed by histological examination. Aprepitant administration decreased total proteins, cells, neutrophils, macrophages BALF. The interleukin (IL)-6, IL-1β, tumor necrosis factor-α, interferon γ, monocyte chemoattractant protein-1, IL-10 homogenates also diminished aprepitant. In conclusion, attenuate mice suggesting its potential therapeutic use clinic.
Language: Английский
Citations
3
Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 195, P. 106500 - 106500
Published: April 12, 2024
Spinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of immune function. Consequently, individuals with SCI often exhibit a spectrum dysfunctions ranging from development damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative gain more comprehensive understanding extent and mechanisms through which SCI-induced dysfunction influences response. In this review, we provide an overview anatomical organization physiology nervous system (ANS), elucidating how impacts its function, particular focus on lymphoid organs activity. We highlight recent advances in intraspinal plasticity that follows may contribute aberrant activity organs. Additionally, discuss sympathetic mediators released by these neuron terminals affect cell Finally, emerging innovative technologies potential clinical interventions targeting ANS as strategy restore normal response SCI.
Language: Английский
Citations
2