Cell and Tissue Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Language: Английский
Chemical Senses, Journal Year: 2023, Volume and Issue: 48
Published: Jan. 1, 2023
Abstract People often confuse smell loss with taste loss, so it is unclear how much gustatory function reduced in patients self-reporting loss. Our pre-registered cross-sectional study design included an online survey 12 languages instructions for self-administering chemosensory tests 10 household items. Between June 2020 and March 2021, 10,953 individuals participated. Of these, 5,225 self-reported a respiratory illness were grouped based on their reported COVID test results: COVID-positive (COVID+, N = 3,356), COVID-negative (COVID−, 602), unknown those waiting result (COVID?, 1,267). The participants who no by symptoms: sudden smell/taste changes (STC, 4,445), other symptoms excluding or (OthS, 832), (NoS, 416). Taste, smell, oral irritation intensities self-assessed abilities rated visual analog scales. Compared to the NoS group, COVID+ was associated 21% reduction (95% confidence interval (CI): 15–28%), 47% CI: 37–56%), 17% 10–25%) intensity. There medium strong correlations between perceived (r 0.84 r 0.68 taste, 0.37 irritation). demonstrates that COVID-19-positive report dysfunction when self-tested stimuli have little none olfactory components. Assessing intensity of items promising, cost-effective screening tool complements self-reports may help disentangle from However, does not replace standardized validated psychophysical tests.
Language: Английский
Citations
11
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: July 17, 2023
During the first waves of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection, olfactory dysfunction (OD) was reported as a frequent clinical sign. The nasal epithelium is one front-line protections against viral infections, and immune responses mucosa may be associated with OD. Two mechanisms underlying OD occurrence in COVID-19 have been proposed: infection sustentacular cells inflammatory reaction epithelium. former triggers latter likely prolongs These two alternative act parallel; more important for because are to entry point SARS-CoV-2 than neurons susceptible early injury. Furthermore, abundantly express transmembrane protease, serine (TMPRSS2) play major role has revealed crucial roles cells. This review aims elucidate how contribute COVID-19–related Understanding aid development improved medical treatments
Language: Английский
Citations
11
Acta Neuropathologica, Journal Year: 2024, Volume and Issue: 147(1)
Published: Jan. 6, 2024
Language: Английский
Citations
4
Physiological Reviews, Journal Year: 2024, Volume and Issue: 104(2), P. 589 - 590
Published: Jan. 11, 2024
Language: Английский
Citations
4
The Scientific Journal of Medical Scholar, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6
Published: Jan. 5, 2025
Background: Corona viruses affect both humans and birds. In humans, the symptoms vary from mild cough, sore throat to severe respiratory tract infection distress. COVID-19 can be presented by difficult breathing, generalized body aches, loss of smell taste. The sudden was described as a definitive diagnostic symptom infection. This study designed investigate histological changes COVID19 on olfactory mucosal epithelium, which associated with temporary or long lasting dysfunction. Patients Methods: prospective study. Twenty patients dysfunction few months after COVID 19 were included represented group. addition, 20 due causes other than (e.g., allergic nasal polypi skull base fracture) comparison (control group). All evaluated in standard techniques. Then, Forty (40) epithelium punch biopsies have been obtained under general anesthesia taking written consent. Data recorded compared between groups. Results: Light Microscopic examination group showed inflammatory among 17 cases atrophied 3 cases, 16 4 control form lymphocytic cells, macrophages, mast goblet cells. There no significant differences groups regarding patient age, special habits, chronic diseases, complications biopsy result biopsy. However duration OD significantly longer (6 (4-8) vs 2 (1-5) months). Conclusion: invades leading reversible that These did not differ inflammation.
Language: Английский
Citations
0
Life, Journal Year: 2025, Volume and Issue: 15(1), P. 56 - 56
Published: Jan. 5, 2025
COVID-19-related persistent olfactory dysfunction (OD) presents remarkable interindividual differences, and little is known about the host genetic factors that are involved in its etiopathogenesis. The goal of this study was to explore underpinning OD through analysis Whole Genome Sequencing data 153 affected subjects, focusing on genes antiviral response regulation. An innovative approach developed, namely assessment association between a "gene score", defined as ratio number homozygous alternative variants within gene length, participants' function. highlighted how an increased score ACE2 associated with worse performance, while IFI44 NDUFAF4 better Considering physiological role proteins encoded by these genes, it can be hypothesized reduced expression may protracted severe inflammatory epithelium, thus worsening patients' smell abilities. Conversely, might decreased response, correlating performance. Overall, identified new play pivotal determining heterogeneity, possibly enabling more personalized effective clinical management for individuals.
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 15, 2025
Language: Английский
Citations
0
Journal of Virology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
ABSTRACT Type III interferons (IFNs) primarily act on epithelial cells and protect against virus infection of the mucosa, whereas type I IFNs more systemically. To date, it has been unknown which subtypes in upper airways, primary site for initial most respiratory viruses, rely IFN or antiviral protection. address this question, we performed a single-cell transcriptomics analysis IFN-mediated response focusing airways mice. This work identified nine distinct cell types derived from olfactory epithelium thirteen epithelium. Interestingly, induced stronger transcriptional than cells, including sustentacular (SUS) Bowman’s gland (BGC), was dominant compared to IFN. SUS BGC, provide structural support maintain integrity sensory neurons, were highly susceptible with mouse-adapted variant severe acute syndrome coronavirus 2 (SARS-CoV-2 MA20) but protected if animals prophylactically treated These findings demonstrate high degree heterogeneity terms interferon-mediated responses reveal potent role protecting IMPORTANCE SARS-CoV-2 infects BGC epithelium, causing an impairment neurons that can result dysfunctions. We observed unexpected compartmentalization within airway found preferentially respond IFN, resulted robust protection BGC. Given proximity central nervous system, hypothesize evolution favored IFN-biased immune tissue limit inflammatory brain. Cell type-specific triggered by different IFNs, should be investigated detail carefully taken into consideration during development IFN-based antivirals clinical use.
Language: Английский
Citations
0
Atmospheric Environment, Journal Year: 2025, Volume and Issue: unknown, P. 121103 - 121103
Published: Feb. 1, 2025
Language: Английский
Citations
0
Indian Journal of Tuberculosis, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0